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51.
52.
Deepti Tandon Anushree D. Patil Jayanti Mania Pramanik Shilpa Kerkar Kiran Munne Shahina Begum Varsha Tryambake Suchitra Surve 《Indian journal of medical microbiology》2022,40(1):144-146
Cervicitis is an inflammatory condition of cervix, when presented along with vaginal discharge; it is termed as cervico-vaginitis. These can be infective, hence important to diagnose due to risk of spreading to upper genital tract. This cross-sectional study was undertaken to evaluate the microbiological spectrum in cervicitis or cervico-vaginitis among 100 sexually active women by Gram stain and Multiplex Real time polymerase chain reaction. Bacterial vaginosis 21(21%) was the most common RTI. Among STIs, genital mycoplasmas were the predominant infections hence further research is required to understand their pathogenesis. 相似文献
53.
Jenny H. Pan Sid P. Kerkar Michael P. Siegenthaler Marybeth Hughes Prakash K. Pandalai 《International journal of surgery case reports》2014,5(10):677-680
INTRODUCTION
Pythiosis is a serious life- and limb-threatening infection endemic to Thailand, but rarely seen in the Western hemisphere. Here, we present a unique case of vascular pythiosis initially managed with limb-sparing vascular bypass grafts complicated by a pseudoaneurysm in our repair.PRESENTATION OF CASE
The patient is a 17 year-old Jamaican male with severe aplastic anemia. He sustained a minor injury to his left leg while fishing in Jamaica, which evolved to become an exquisitely tender inguinal swelling. His physical exam and imaging were significant for arteriovenous fistula with limb ischemia. Pathology obtained during surgery for an extra-anatomic vascular bypass showed extensive invasion by Pythium insidiosum. He later developed a pseudoaneurysm at the site of proximal anastomosis and required urgent intervention.DISCUSSION
This patient presented with a rare, but classic case of vascular pythiosis, which was unrecognized at the time of presentation. A variety of therapeutic modalities have been used to treat this disease, including antibiotics, antifungals, and immunotherapy, but the ultimate management of vascular pythiosis is surgical source control.CONCLUSION
A high index of suspicion in susceptible patients is needed for timely diagnosis of vascular pythiosis to achieve optimal source control. 相似文献54.
Arnon R Annunziato R Miloh T Wasserstein M Sogawa H Wilson M Suchy F Kerkar N 《Pediatric transplantation》2011,15(4):400-405
Patients with HT-1 can develop progressive liver disease and have a high incidence of HCC. LT is indicated in patients with fulminant liver failure, HCC or decompensated chronic liver disease refractory to NTBC. To determine the need for LT and outcomes after LT in children with HT-1. Children with HT-1 who had LT between 10/1987 and 5/2008 were identified from the UNOS database. Of 11,467 children in the UNOS database, 125 (1.1%) required LT secondary to HT-1. Mean age at LT was two and half yr (s.d. ± 3.6 yr). Mean age at LT during the first 10 yr of the study (1.82, s.d. ± 2.86 yr) was significantly lower than in the last decade (3.70, s.d. ± 4.42 yr), p = 0.01. Nearly half of the patients (58, 46.4%) were transplanted between 1988 and 1992. Overall, one- and five-yr patient survival was 90.4% and 90.4%, respectively. LT is a valuable option for children with HT-1 with fulminant liver failure or when medical treatment fails. The rate of LT for children with HT-1 has decreased and age at transplant increased over the last decade most probably reflecting the effect of early diagnosis and treatment with NTBC. 相似文献
55.
Jaime Chu Nanda Kerkar Tamir A. Miloh Gonzalo Rodriguez‐Laiz Blair Lewis Anondo Stangl Kimberly P. Newton Kishore Iyer Ronen Arnon 《Pediatric transplantation》2011,15(8):E156-E161
Chu J, Kerkar N, Miloh TA, Rodriguez‐Laiz G, Lewis B, Stangl A, Newton KP, Iyer K, Arnon R. Roux‐en‐Y loop varices in children with portal hypertension after liver transplantation: An unusual cause of “obscure” gastro intestinal bleeding. Pediatr Transplantation 2011: 15: E156–E161. © 2010 John Wiley & Sons A/S. Abstract: PHALT may result from graft dysfunction, portal vein thrombosis, arterio‐venous fistulas and can lead to GIB, commonly from bleeding esophageal varices. We present three children with GIB requiring multiple blood transfusions that were diagnosed with RY Loop bleeding. Routine EGD, colonoscopy, and CE failed to reveal the bleeding source. However, enteroscopy revealed large varices at the site of hepaticojejunostomy anastomosis in all. Our experience demonstrates that RY loop varices in children with PHALT are a rare and treatable cause of obscure GI bleeding. 相似文献
56.
Natural history of aortic regurgitation (AR) following transcatheter closure (TCC) of intracardiac or aortopulmonary shunt needs to be explored. AR can appear immediately or later after TCC and may increase or regress. We describe a previously unreported AR development following successful TCC of aortopulmonary window. 相似文献
57.
Muranski P Borman ZA Kerkar SP Klebanoff CA Ji Y Sanchez-Perez L Sukumar M Reger RN Yu Z Kern SJ Roychoudhuri R Ferreyra GA Shen W Durum SK Feigenbaum L Palmer DC Antony PA Chan CC Laurence A Danner RL Gattinoni L Restifo NP 《Immunity》2011,35(6):972-985
Th17 cells have been described as short lived, but this view is at odds with their capacity to trigger protracted damage to normal and transformed tissues. We report that Th17 cells, despite displaying low expression of CD27 and other phenotypic markers of terminal differentiation, efficiently eradicated tumors and caused autoimmunity, were long lived, and maintained a core molecular signature resembling early memory CD8(+) cells with stem cell-like properties. In addition, we found that Th17 cells had high expression of Tcf7, a direct target of the Wnt and β-catenin signaling axis, and accumulated β-catenin, a feature observed in stem cells. In vivo, Th17 cells gave rise to Th1-like effector cell progeny and also self-renewed and persisted as IL-17A-secreting cells. Multipotency was required for Th17 cell-mediated tumor eradication because effector cells deficient in IFN-γ or IL-17A had impaired activity. Thus, Th17 cells are not always short lived and are a less-differentiated subset capable of superior persistence and functionality. 相似文献
58.
Regelmann MO Greig F Kerkar N Rapaport R 《The Journal of pediatrics》2012,160(2):355; author reply 356
59.
We describe an unusual complication of the Inoue balloon technique, which has been treated successfully by application of a different technique. This technique has not been described elsewhere to the best of our knowledge. 相似文献
60.