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51.
52.
Plasma interleukin-8 (IL-8) concentrations were measured in patients with atopic dermatitis. Plasma IL-8 was not detected in 25 controls (0/25), in allergic rhinitis (0/20), or in bronchial asthma during remission (0/13), while low concentrations of IL-8 were detectable in a few patients with urticaria (1/19), contact dermatitis (4/17), and bronchial asthma at the time of attack (6/16). In contrast, IL-8 was detectable in most cases of atopic dermatitis (41/52). Moreover, IL-8 concentrations were significantly higher in severe than in mild or moderate atopic dermatitis. IL-8 concentrations decreased as atopic dermatitis was improved by treatment, and IgE production in vitro was also decreased while serum IgE concentrations remained unchanged. IL-8 measurement may be a useful tool for the study of the pathogenesis and clinical course of atopic dermatitis. 相似文献
53.
EA Mitchell KP Nelson JMD Thompson AW Stewart BJ Taylor RPK Ford R Scragg DMO Becroft EA Allen IB Hassall A Roberts 《Acta paediatrica (Oslo, Norway : 1992)》1994,83(8):815-818
We investigated the relationship between travel and changes in routine and the sudden infant death syndrome (SIDS) among 485 SIDS cases compared with 1800 randomly selected control infants. There was no increased risk of SIDS with travel. Special events, such as christenings, were not associated with an increased risk of SIDS. However, visits to and by friends or relatives were associated with a significantly reduced risk of SIDS after controlling for potential confounders (odds ratios = 0.70; 95% confidence interval = 0.52, 0.96). These findings may indicate less social support in SIDS cases. 相似文献
54.
DK Mishra A Chaturvedi A Sharma H Subramanya Harsh Kumar R Varadarajulu KP Anand 《Medical Journal Armed Forces India》2004,60(4):337-341
Background
Bleeding disorders are commonly seen in clinical practice. von Willebrand Disease (vWD), is the commonest and yet a profoundly under diagnosed cause, having a wide spectrum of clinical presentation. Of its three types, type 1 vWD (70% of the total vWD cases) has the mildest and a highly variable clinical and laboratory presentation.Methods
A series of ten cases of vWD were comprehensively evaluated using recommended diagnostic parameters and therapeutic interventions.Results
All major types of vWD were represented. A female preponderance, with primary presentation in the form of muco-cutaneous bleeds was observed. A positive history of consanguineous parental marriage and family history of bleeding disorder was elicited in two and three patients respectively. Nine patients were found to be anemic and thrombocytopenia was present in only one. Bleeding time by modified template (SIMPLATE) method, along with activated partial thromboplastin time (APTT) was increased in all ten cases and of these, nine had low factor VIII: C levels. Ristocetin induced platelet aggregation studies were abnormal in all the five cases it was performed. vWF:RCo activity determined in one individual was shown to be low. vWF:Ag assay was done in four cases revealing a near complete absence of von Willebrand factor antigen in one and mildly decreased levels in the other three. vWF multimer assay was advised in three cases. DDAVP, plasma derived vWF, blood products and local antifibrinolytics were used as primary modalities of treatmentConclusion
Thus, strong clinical suspicion, thorough clinical evaluation and judicious use of investigations including repeated investigations at different times are needed for making a diagnosis of vWD.Key Words: Bleeding disorders, von Willebrand Disease 相似文献55.
56.
Digital subtraction angiography system evaluation with phantoms 总被引:1,自引:0,他引:1
Advances in digital subtraction angiography imaging demonstrate the need for critical evaluation of the performance of digital subtraction equipment. The design of a phantom set for noninvasive assessment of the imaging quality of digital subtraction equipment is described; components include a remotely controlled transport system and individual patterns to evaluate the contrast and detail properties of the image intensifier, low-contrast sensitivity and resolution of the system, geometric distortion of image, linearity, mechanical and electronic stability of equipment, and effects of bone and bowel gas on iodine perception. The performance of an add-on digital radiographic system is presented, along with radiation exposure levels at the image intensifier for a range of radiographic techniques. 相似文献
57.
A founder mutation in the gamma-sarcoglycan gene of gypsies possibly predating their migration out of India 总被引:4,自引:2,他引:2
Piccolo F; Jeanpierre M; Leturcq F; Dode C; Azibi K; Toutain A; Merlini L; Jarre L; Navarro C; Krishnamoorthy R; Tome FM; Urtizberea JA; Beckmann JS; Campbell KP; Kaplan JC 《Human molecular genetics》1996,5(12):2019-2022
We investigated the molecular basis of a severe form of early onset
autosomal recessive muscular dystrophy with sarcoglycan (SG) deficiency in
seven large Gypsy families living in different parts of Western Europe and
apparently not closely related. They were linked to the LGMD2C locus
(13q12) suggesting a primary defect in the gamma-SG gene coding for the 35
kDa dystrophin-associated glycoprotein. All of the 18 investigated patients
were homozygous for the same G-->A transition in codon 283 producing the
replacement of a conserved cysteine of the extra-cellular domain of the
protein by a tyrosine. All affected chromosomes in homozygous and
heterozygous relatives carried the same allele 5 of the intragenic marker
D13S232. Flanking markers were studied to delineate a common ancestral
haplotype, the size of which was used to compute the date of the founding
mutation. We found evidence that the mutation occurred between 60 and 200
generations ago, therefore possibly predating the commonly accepted date of
migration of the Gypsy ancestors out of India.
相似文献
58.
采用HPLC测定睾酮乳膏中睾酮的含量,以甲醇-水(70:30)为流动相,波长240nm,在40-360μg/ml范围内线性关系良好r=0.9999,本法操作简便,回收率高。 相似文献
59.
60.
BACKGROUND & AIMS: The effects of short-term antigenic activation of mast cells on the gastrointestinal tract have been well characterized, but little is known about the effects of long-term exposure to antigen on mucosal mast cell reactivity. The aim of this study was to determine the effects of long-term antigen exposure on mucosal mast cell reactivity in the gastrointestinal mucosa. METHODS: Rats sensitized to chicken ovalbumin were orally challenged (short-term or long-term) with antigen. Rat mast cell protease II (RMCP-II) content was measured in serum as an index of mucosal mast cell degranulation. RESULTS: Short- term oral antigen challenge caused a 30-fold increase in serum RMCP-II levels. RMCP-II release was markedly diminished in long term-challenged rats (P < 0.001), despite increased tissue RMCP-II levels in stomach and jejunum. Although short-term antigen challenge significantly increased gastric acid secretion, no such response was observed after the long-term antigen challenge. In rats undergoing long-term challenge, a significant release of RMCP-II in response to intravenous antigen was not observed; however, mucosal mast cells remained responsive to intravenous anti-immunoglobulin E. CONCLUSIONS: Repeated activation of mucosal mast cells results in a progressive diminution of RMCP-II release not attributable to depletion of this mediator. This may represent an adaptive response aimed at minimizing the potentially deleterious effects of repeated exposure to an antigen. (Gastroenterology 1996 Dec;111(6):1516-23) 相似文献