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排序方式: 共有1332条查询结果,搜索用时 15 毫秒
991.
Laura Pirhonen Elisabeth Hansson Olofsson Andreas Fors Inger Ekman Kristian Bolin 《Health policy (Amsterdam, Netherlands)》2017,121(2):169-179
Objectives
To study the effects of person-centred care provided to patients with acute coronary syndrome, using four different health-related outcome measures. Also, to examine the performance of these outcomes when measuring person-centred care.Data and method
The data used in this study consists of primary data from a multicentre randomized parallel group, controlled intervention study for patients with acute coronary syndrome at Sahlgrenska University Hospital in Gothenburg, Sweden. The intervention and control group consisted of 94 and 105 patients, respectively. The effect of the intervention on health-related outcomes was estimated, controlling for socio-economic and disease-related variables.Results
Patients in the intervention group reported significantly higher general self-efficacy than those in the control group six months after intervention start-up. Moreover, the intervention group returned to work in a greater extent than controls; their physical activity level had increased more and they had a higher EQ-5D score, meaning higher health-related quality of life. These latter effects are not significant but are all pointing towards the beneficial effects of person-centred care. All the effects were estimated while controlling for important socio-economic and disease-related variables.Conclusion
The effectiveness of person-centred care varies between different outcomes considered. A statistically significant beneficial effect was found for one of the four outcome measures (self-efficacy). The other measures all captured beneficial, but not significant, effects. 相似文献992.
Racial differences in incident de novo donor‐specific anti‐HLA antibody among primary renal allograft recipients: results from a single center cohort study
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Matthew J. Everly Kimberly P. Briley Carl E. Haisch Georg Dieplinger Paul Bolin Scott A. Kendrick Claire Morgan Angela Q. Maldonado Lorita M. Rebellato 《Transplant international》2017,30(6):566-578
Controversy exists as to whether African American (AA) transplant recipients are at risk for developing de novo donor‐specific anti‐human leucocyte antigen (HLA) antibody (dnDSA). We studied 341 HLA‐mismatched, primary renal allograft recipients who were consecutively transplanted between 3/1999 and 12/2010. Sera were collected sequentially pre‐ and post‐transplant and tested for anti‐HLA immunoglobulin G (IgG) via single antigen bead assay. Of the 341 transplant patients (225 AA and 116 non‐AA), 107 developed dnDSA at a median of 9.2 months post‐transplant. AA patients had a 5‐year dnDSA incidence of 35%. This was significantly higher than the 5‐year dnDSA incidence for non‐AA patients (21%). DQ mismatch (risk) and receiving a living‐related donor (LRD) transplant (protective) were transplant factors associated with dnDSA. Within the AA patient cohort, HLA‐DQ mismatch, not‐receiving a LRD transplant, nonadherence and BK viraemia were the most common factors associated with early dnDSA (occurring <24 months post‐transplant). Nonadherence and pretransplant diabetes history were the strong precursors to late dnDSA. Despite the higher rates of dnDSA in the AA cohort, post‐dnDSA survival was the same in AA and non‐AA patients. This study suggests that DQ matching, increasing LRD transplantation in AA patients and minimizing under‐immunosuppression will be key to preventing dnDSA. 相似文献
993.
目的:探讨TNF-α对兔胆管成纤维细胞P311/TGF-β1/α-SMA通路的影响及川芎嗪的干预作用。方法:分离、培养正常家兔胆管成纤维细胞并鉴定,将胆管成纤维细胞分别给予TNF-α、TNF-α联合不同浓度的TMP(0.08、0.4、2.0 mg/m L)干预48 h,以无处理的胆管成纤维细胞为空白对照,用CCK-8法检测细胞增殖水平;real-time PCR检测细胞P311、TGF-β1、α-SMA m RNA表达;Western blot检测细胞TGF-β1、α-SMA蛋白表达。结果:与空白对照比较,胆管成纤维细胞经TNF-α处理后,增殖明显增强,P311、TGF-β1、α-SMA m RNA以及TGF-β1、α-SMA蛋白表达明显上调(均P0.05);TMP对TNF-α的上述效应有抑制作用,并且呈现浓度依耐趋势,其中0.4、2.0 mg/m L的TMP有明显作用(均P0.05)。结论:TNF-α可能通过调控P311/TGF-β1/α-SMA信号通路促进胆管成纤维细胞增殖,TMP能抑TNF-α对该通路的活化,故可能对良性胆道狭窄有防治作用。 相似文献
994.
野葡萄根原植物的调查研究 总被引:8,自引:5,他引:8
调查采集了湖北省麻城地区治疗慢性骨髓炎的野葡萄根原植物,鉴定出是蛇葡萄Ampelop-sis sinca以及光叶蛇葡萄、异叶蛇葡萄和三裂叶蛇葡萄等四种植物的根。 相似文献
995.
Some 20 sheep died 1 at a time on a farm in Fleming County, KY, in late July of 1999 after consumption of Asclepias viridis Walter. Major histological lesions were mild multifocal nonsuppurative myocarditis. Gross pathology revealed wet and heavy lungs. Many affected animals had a hunched appearance, and marked posterior paresis was also observed. 相似文献
996.
997.
Hulkower Keren I. Coffey John W. Levin Wayne Anderson Celia M. Chen Ting Hope William C. Bolin David R. Morgan Douglas W. 《Inflammation research》1993,39(1):C5-C7
We investigated the temporal relationship between the increase in enzymatic activity and protein of a high molecular weight (100 kDa), cytosolic PLA2 (cPLA2) in interleukin-1β (IL-1β)-treated rheumatoid synovial fibroblasts (RSF). Both of these responses increased according to a similar time-course which correlates with PGE2 production by these cells. In contrast, 14 kDa, secreted PLA2 (sPLA2), which was also produced by RSF, was not affected by IL-1β treatment. These findings support that an augmentation of cPLA2 activity, caused by an induction of cPLA2 protein, rather than sPLA2, is temporally associated with increased PGE2 production in IL-1β-treated RSF. 相似文献
998.
Recombinant HpaA purified from Escherichia coli has biological properties similar to those of native Helicobacter pylori HpaA 总被引:5,自引:0,他引:5
Lundstrom A Bolin I Bystrom M Nystrom S 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2003,111(3):389-397
The aim of this study was to recombinantly produce and purify Helicobacter pylori adhesin A (HpaA) from Escherichia coli and compare it to purified native H. pylori HpaA, for potential use as a vaccine antigen. The hpaA gene was cloned from H. pylori, transferred to two different expression vectors, and transformed into E. coli. Expression of rHpaA was analysed by immunoblot, inhibition ELISA, and semi-quantitative dot-blot. Using affinity chromatography, rHpaA was purified from E. coli and native HpaA from H. pylori. The binding of both purified proteins to sialic acid was analysed and antibody titres to native and rHpaA were compared after intraperitoneal immunisation of C57/Bl mice. The rHpaA protein was highly expressed in E. coli from both vectors. Purified recombinant and native HpaA bound similarly to fetuin but also to the non-sialylated asialofetuin. Both native HpaA and rHpaA induced comparable amounts of specific antibodies in serum after immunisation and they were identical in double immunodiffusion. In conclusion, rHpaA was successfully produced in E. coli. Purified rHpaA showed biological properties similar to those of native HpaA isolated from H. pylori and may therefore be further used as an antigen in the development of a vaccine against H. pylori infection. 相似文献
999.
Comparison of the complete genomic sequence of the border disease virus, BD31, to other pestiviruses
The genus Pestivirus is composed of hog cholera virus (HCV) [also known as classical swine fever virus (CSFV)], bovine viral diarrhea virus (BVDV), and border disease virus (BDV). Complete sequences have been published for HCV (or CSFV) and the two genotypes of BVDV (BVDV1 and BVDV2). In this study the complete sequence of the border disease virus (BDV), BD31, was determined. BD31 was isolated from a lamb with hairy shaker syndrome and is the BDV type virus offered by ATCC (ATCC VR-996). The genome was 12268 nucleotides long and had a single large open reading frame (ORF) beginning at nucleotide 357 and ending at nucleotide 12045. The sequence identity of the predicted amino acid sequence of BD31 and other published pestivirus sequences varied from 71% to 78%. Phylogenetic analysis of available complete genomic sequences segregated pestiviruses into two branches. One branch contained BD31 and HCV (or CSFV) isolates while the other branch contained BVDV1 and BVDV2 isolates. Pestiviruses from the same branch were similar in the length of the 5′ and 3′ untranslated regions (UTR). When complete genomic sequences were compared among BD31, HCV (or CSFV), BVDV1 and BVDV2, the highest sequence identity was observed in the 5′ UTR. Within the ORF, the highest sequence identity was observed in the genomic region coding for the nonstructural viral polypeptide p80. 相似文献
1000.
W A Robinson M A Entringer R W Bolin O G Stonington 《The New England journal of medicine》1977,297(21):1129-1134
We attempted to determine the effect of live bacteria (Staphylococcus epidermidis) on granulocyte colony-stimulating-factor production by human peripheral blood mononuclear cells (monocytes and lymphocytes) in vitro. Addition of bacteria to mononuclear-cell cultures enhanced colony-stimulating-factor production by these cells, as assayed on both human and mouse bone marrow. Addition of peripheral blood granulocytes to parallel cultures eliminated this enhancement effect, presumably by bacterial removal or inactivation. These data suggest that micro-organisms may have a pivotal role in granulocyte production and maturation by serving as a stimulus to increase colony-stimulating-factor production and also as negative control through their removal by the newly formed granulocytes. 相似文献