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Chikako Kusunoki Takuya Hamakawa Kazuhiro Nishikawa Hiromichi Sato Sayumi Imamura Satoru Miyahara Yu Sakano Hazuki Miyazaki Hiroto Seto Ryuta Ueda Reishi Toshiyama Masaaki Miyo Yusuke Takahashi Kenji Sakai Masakazu Miyake Atsushi Miyamoto Takeshi Kato Kiyoshi Mori Motohiro Hirao 《Asian journal of endoscopic surgery》2021,14(4):794-797
Laparoscopic wedge resection (LWR) for intraluminal gastrointestinal stromal tumor (GIST) leads to excessive resection of normal gastric wall. We report a case of GIST around the cardia successfully treated with full-thickness partial resection using a hybrid approach of laparoscopic surgery and single-incision intragastric surgery (SIIGS). A 69-year-old woman had a 5 cm intraluminal GIST at the posterior wall around the cardia. Submucosal injection of glycerin and indigo carmine was performed with transoral endoscopy. Circumferential seromuscular incision followed by placement of seromuscular sutures to invert the lesion into the stomach was performed under laparoscopy. By SIIGS, resection of the inverted mucosa and retrieval of the tumor were completed. A hybrid approach consisting of laparoscopic wall-inversion surgery and SIIGS was useful for intraluminal GIST and may expand the indications for laparoscopic wall-inversion surgery by removing size limitations. 相似文献
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Low‐dose etretinate shows promise in management of punctate palmoplantar keratoderma type 1: Case report and review of the published work
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Toshifumi Nomura Reine Moriuchi Masae Takeda Shotaro Suzuki Kazuhiro Kikuchi Takamasa Ito Hiroshi Shimizu Satoko Shimizu 《The Journal of dermatology》2015,42(9):889-892
Punctate palmoplantar keratoderma type 1 (PPKP1) is a rare autosomal dominant disorder of keratinization, clinically characterized by punctate keratotic papules affecting the palmoplantar skin. Loss‐of‐function mutations in AAGAB have recently been reported as a cause of PPKP1. Despite the discovery of the genetic cause of PPKP1, pathogenesis‐based therapies are still unavailable. Moreover, little is known about the effectiveness of treatments for PPKP1. In this study, we analyzed a Japanese woman with PPKP1 and identified a novel frame‐shift mutation c.195_198del4 (p.Lys66Phefs*43) in AAGAB. Moreover, low‐dose etretinate was effective in improving the PPKP1 lesions in our patient. Our published work review identified only eight cases of PPKP1 with successful response to topical or systemic treatments. Notably, six of the cases were successfully treated with systemic retinoids. Thus, this study clearly provides further evidence that PPKP1 is caused by AAGAB mutations and that systemic retinoids are the most promising current treatment for PPKP1. 相似文献
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Mitral annular plane systolic excursion/left ventricular length (MAPSE/L) as a simple index for assessing left ventricular longitudinal function in children
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