全文获取类型
收费全文 | 3256篇 |
免费 | 207篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 87篇 |
儿科学 | 50篇 |
妇产科学 | 60篇 |
基础医学 | 397篇 |
口腔科学 | 43篇 |
临床医学 | 286篇 |
内科学 | 821篇 |
皮肤病学 | 62篇 |
神经病学 | 360篇 |
特种医学 | 60篇 |
外科学 | 414篇 |
综合类 | 9篇 |
预防医学 | 88篇 |
眼科学 | 33篇 |
药学 | 273篇 |
中国医学 | 13篇 |
肿瘤学 | 435篇 |
出版年
2023年 | 11篇 |
2022年 | 46篇 |
2021年 | 79篇 |
2020年 | 32篇 |
2019年 | 69篇 |
2018年 | 73篇 |
2017年 | 35篇 |
2016年 | 69篇 |
2015年 | 77篇 |
2014年 | 84篇 |
2013年 | 121篇 |
2012年 | 208篇 |
2011年 | 194篇 |
2010年 | 131篇 |
2009年 | 90篇 |
2008年 | 177篇 |
2007年 | 199篇 |
2006年 | 158篇 |
2005年 | 184篇 |
2004年 | 182篇 |
2003年 | 128篇 |
2002年 | 169篇 |
2001年 | 76篇 |
2000年 | 88篇 |
1999年 | 76篇 |
1998年 | 52篇 |
1997年 | 43篇 |
1996年 | 36篇 |
1995年 | 31篇 |
1994年 | 28篇 |
1993年 | 27篇 |
1992年 | 73篇 |
1991年 | 44篇 |
1990年 | 53篇 |
1989年 | 46篇 |
1988年 | 38篇 |
1987年 | 37篇 |
1986年 | 36篇 |
1985年 | 43篇 |
1984年 | 18篇 |
1983年 | 19篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1980年 | 11篇 |
1979年 | 16篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1971年 | 9篇 |
1967年 | 9篇 |
1966年 | 7篇 |
排序方式: 共有3491条查询结果,搜索用时 31 毫秒
61.
Yamagishi H Koike T Ohara S Kobayashi S Ariizumi K Abe Y Iijima K Imatani A Inomata Y Kato K Shibuya D Aida S Shimosegawa T 《World journal of gastroenterology : WJG》2008,14(9):1358-1364
AIM:To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan.
METHODS: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged 〉 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period.
RESULTS: The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year agegroup. Dysphagia was also significantly more frequent in female patients.
CONCLUSION: The prevalence of typical GERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group. 相似文献
METHODS: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged 〉 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period.
RESULTS: The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year agegroup. Dysphagia was also significantly more frequent in female patients.
CONCLUSION: The prevalence of typical GERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group. 相似文献
62.
63.
64.
Furuya Takefumi Oh Koei Ikari Katsunori Inoue Eisuke Tanaka Eiichi Yamanaka Hisashi Harigai Masayoshi 《Clinical rheumatology》2022,41(2):405-410
Clinical Rheumatology - This study aimed to evaluate the prevalence of, and the factors associated with, frailty in Japanese patients with rheumatoid arthritis (RA). Patients with RA enrolled in... 相似文献
65.
G‐cell hyperplasia of the stomach induces ECL‐cell proliferation in the pyloric glands in a paracrinal manner 下载免费PDF全文
Atsuko Kasajima Fumiyoshi Fujishima Takanori Morikawa Shuhei Kawasaki Sachiko Konosu‐Fukaya Yukiko Shibahara Tadaho Nakamura Takeo Yoshikawa Katsunori Iijima Tomoyuki Koike Mika Watanabe Chikashi Shibata Hironobu Sasano 《Pathology international》2015,65(5):259-263
An inhibitory mechanism toward gastrin hypersecretion is significantly different between G‐cell hyperplasia and gastrinoma despite the common clinical manifestations; hypergastrinemia and its related persistent gastric ulcers. We recenlty studied the G‐cell, d ‐cell and ECL‐cell density in a case of G‐cell hyperplasia. The 70‐year‐old patient has been treated for persistent gastric ulcers with a markedly increased plasma gastrin (5600 pg/mL). The stomach was surgically resected because of the obstruction associated with ulcer scars. The number of G‐cells in the pyloric glands was quantified on the surgical specimens and G‐cell hyperplasia was histolopathologically identified. Immunostainig of histidine decarboxylate revealed the presence of ECL‐cell hyperplasia in the pyloric glands and its density was significantly and positively correlated with G‐cell density. Somatostatin immunoreactive cells (d ‐cells) increased in their number in the oxyntic glands. These results all indicated that hypersecretion of gastrin in G‐cell hyperplasia could induce ECL‐cell proliferation in a paracrinal manner. In addition, relatively non‐prominent endocrinological features in the G‐cell hyperplasia compared to gastrinoma could be also related to the paracrinal somatostatin inhibitory effects upon ECL‐cells in the pyloric glands. 相似文献
66.
Yuki Igarashi Sho Tashiro Yuki Enoki Kazuaki Taguchi Kazuaki Matsumoto Hiroki Ohge Hiromichi Suzuki Atsushi Nakamura Nobuaki Mori Yoshitomo Morinaga Yuka Yamagishi Sadako Yoshizawa Katsunori Yanagihara Hiroshige Mikamo Hiroyuki Kunishima 《Journal of infection and chemotherapy》2018,24(11):907-914
At present, vancomycin (VCM) and metronidazole (MNZ) are used for the first-line standard treatment of Clostridioides difficile infection (CDI). However, their differential use has not been sufficiently investigated. In this study, a meta-analysis on differences in the efficacy for CDI between VCM and MNZ was performed. Reports of randomized controlled studies using VCM or MNZ to treat CDI were surveyed. Meta-analysis was performed using the Mantel-Haenszel method and random-effects model, and the risk ratio and 95% confidence interval were calculated. Excluding overlapping reports, 1043 reports were extracted and 5 randomized controlled studies were extracted. There was no difference in therapeutic effects for CDI between VCM and MNZ (RR = 1.08, 95% CI (0.99–1.17), p = 0.09, I2 = 37%). On subgroup analysis by the severity, there was no difference in the clinical effects for CDI between VCM and MNZ in non-severe cases (risk ratio: 1.09, 95% confidence interval: 1.00–1.19, p = 0.06), but the clinical effects of VCM were significantly higher than those of MNZ in severe cases (risk ratio: 1.19, 95% confidence interval: 1.02–1.39, p = 0.03). No significant difference was noted in the recurrence rate, incidence of adverse event, time to exhibit therapeutic effects, or judgment of the bacteriological effects. As the therapeutic effects of VCM were superior in severe CDI cases, VCM should be considered first in severe cases. 相似文献
67.
Yoshio Takesue Shinya Kusachi Hiroshige Mikamo Junko Sato Akira Watanabe Hiroshi Kiyota Satoshi Iwata Mitsuo Kaku Hideaki Hanaki Yoshinobu Sumiyama Yuko Kitagawa Kazuhiko Nakajima Takashi Ueda Motoi Uchino Toru Mizuguchi Yoshiyasu Ambo Masafumi Konosu Keiichiro Ishibashi Katsunori Yanagihara 《Journal of infection and chemotherapy》2018,24(5):330-340
The principle of empirical therapy for patients with intra-abdominal infections (IAI) should include antibiotics with activity against Enterobacteriaceae and Bacteroides fragilis group species. Coverage of Pseudomonas aeruginosa, Enterobacter cloacae, and Enterococcus faecalis is also recommended for hospital-associated IAI. A nationwide survey was conducted to investigate the antimicrobial susceptibility of pathogens isolated from postoperative IAI. All 504 isolates were collected at 26 institutions and referred to a central laboratory for susceptibility testing. Lower susceptibility rates to ciprofloxacin and cefepime were demonstrated in Escherichia coli. Among E. coli, 24.1% of strains produced extended-spectrum β-lactamase (ESBL). Carbapenems, piperacillin/tazobactam, cephamycins/oxacephem, aminoglycosides, and tigecycline had high activity against E. coli, including ESBL-producing isolates. Among E. cloacae, low susceptibility rates to ceftazidime were demonstrated, whereas cefepime retained its activity. P. aeruginosa revealed high susceptibility rates to all antimicrobials tested except for imipenem. Among B. fragilis group species, low levels of susceptibility were observed for cefoxitin, moxifloxacin, and clindamycin, and high susceptibility rates were observed for piperacillin/tazobactam, meropenem, and metronidazole. Ampicillin, piperacillin, and glycopeptides had good activity against E. faecalis. Imipenem had the highest activity against E. faecalis among carbapenems. In conclusion, we suggested the empirical use of antimicrobials with the specific intent of covering the main organisms isolated from postoperative IAI. Piperacillin/tazobactam, meropenem, or doripenem, are appropriate in critically ill patients. Combination therapy of cefepime (aztreonam in patients with β-lactam allergy) plus metronidazole plus glycopeptides, imipenem/cilastatin or cephamycins/oxacephem plus ciprofloxacin plus metronidazole are potential therapeutic options. 相似文献
68.
Takashi Hanzawa Tadao Matsunaga Tomoyuki Koike Atsushi Kanno Atsushi Masamune Katsunori Iijima 《Minimally invasive therapy & allied technologies》2018,27(4):226-232
Introduction: Although measuring the pressure of the sphincter of Oddi and the bile duct is considered to be an important examination, called Sphincter of Oddi manometry (SOM), some complications related to the SOM device remain unsolved.Material and methods: To decrease adverse complications, we developed a 0.46?mm manometry and we performed some in vitro studies.Results: We successfully developed a 0.46?mm SOM. The diameter is the thinnest size used in endoscopic examinations. The results of in vitro studies show the suitability as SOM.Conclusion: This device will decrease the risks related to SOM examination. To confirm the safety and feasibility, further studies including in vivo studies will be needed. 相似文献
69.
70.
Miwa Kawanaka Ken Nishino Yumiko Morimoto Katsunori Ishii Tomohiro Tanikawa Noriyo Urata Mitsuhiko Suehiro Takako Sasai Ken Haruma Hirofumi Kawamoto 《Internal medicine (Tokyo, Japan)》2021,60(9):1397
A 44-year-old patient progressed from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) cirrhosis. She was diagnosed with NAFL via a liver biopsy. At 56 years old, she was diagnosed with NASH stage 3 via a second liver biopsy. One year later, she was diagnosed with NASH cirrhosis via a third liver biopsy. This is the first study to report the gradual deterioration of liver histology shown via three liver biopsies and fibrosis markers in a patient who progressed from NAFL to NASH cirrhosis. Following menopause, it is necessary to be aware of the rapid development of liver fibrosis. 相似文献