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71.
Barnett Alana Edwards Katie Harper Rebecca Evans Elizabeth Alexander Derina Choudhary Mohini Richards Gareth 《Journal of autism and developmental disorders》2021,51(6):1866-1879
Journal of Autism and Developmental Disorders - Previous studies have reported positive correlations between autistic traits and disordered eating, though it is unclear whether the association is... 相似文献
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Amrita Mandal Hiu-Tung C. Wong Katherine Pinter Natalie Mosqueda Alisha Beirl Richa Madan Lomash Sehoon Won Katie S. Kindt Catherine M. Drerup 《The Journal of neuroscience》2021,41(7):1371
In neurons, mitochondria are transported by molecular motors throughout the cell to form and maintain functional neural connections. These organelles have many critical functions in neurons and are of high interest as their dysfunction is associated with disease. While the mechanics and impact of anterograde mitochondrial movement toward axon terminals are beginning to be understood, the frequency and function of retrograde (cell body directed) mitochondrial transport in neurons are still largely unexplored. While existing evidence indicates that some mitochondria are retrogradely transported for degradation in the cell body, the precise impact of disrupting retrograde transport on the organelles and the axon was unknown. Using long-term, in vivo imaging, we examined mitochondrial motility in zebrafish sensory and motor axons. We show that retrograde transport of mitochondria from axon terminals allows replacement of the axon terminal population within a day. By tracking these organelles, we show that not all mitochondria that leave the axon terminal are degraded; rather, they persist over several days. Disrupting retrograde mitochondrial flux in neurons leads to accumulation of aged organelles in axon terminals and loss of cell body mitochondria. Assays of neural circuit activity demonstrated that disrupting mitochondrial transport and function has no effect on sensory axon terminal activity but does negatively impact motor neuron axons. Taken together, our work supports a previously unappreciated role for retrograde mitochondrial transport in the maintenance of a homeostatic distribution of mitochondria in neurons and illustrates the downstream effects of disrupting this process on sensory and motor circuits.SIGNIFICANCE STATEMENT Disrupted mitochondrial transport has been linked to neurodegenerative disease. Retrograde transport of this organelle has been implicated in turnover of aged organelles through lysosomal degradation in the cell body. Consistent with this, we provide evidence that retrograde mitochondrial transport is important for removing aged organelles from axons; however, we show that these organelles are not solely degraded, rather they persist in neurons for days. Disrupting retrograde mitochondrial transport impacts the homeostatic distribution of mitochondria throughout the neuron and the function of motor, but not sensory, axon synapses. Together, our work shows the conserved reliance on retrograde mitochondrial transport for maintaining a healthy mitochondrial pool in neurons and illustrates the disparate effects of disrupting this process on sensory versus motor circuits. 相似文献
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Liu Xulin Dounavi Maria-Eleni Ritchie Karen Wells Katie Ritchie Craig W. Su Li Muniz-Terrera Graciela O’Brien John T. 《Journal of neurology》2021,268(5):1962-1971
Journal of Neurology - Structural brain changes associated with Alzheimer’s disease (AD) can occur decades before the onset of symptoms. The Cardiovascular Risk Factors, Aging, and Dementia... 相似文献
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Solriamfetol for Excessive Daytime Sleepiness in Parkinson's Disease: Phase 2 Proof-of-Concept Trial
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Toffano Roberta Burgio Francesca Palmer Katie Benavides-Varela Silvia Meneghello Francesca Orrù Graziella Sartori Giuseppe Arcara Giorgio Semenza Carlo 《Neurological sciences》2021,42(10):4183-4191
Neurological Sciences - Financial capacity is the ability to manage money and finances according to a person’s values and self-interests. In Italy, the first instrument specifically designed... 相似文献
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Detecting the effects of Fabry disease in the adult human brain with diffusion tensor imaging and fast bound‐pool fraction imaging 下载免费PDF全文
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