全文获取类型
收费全文 | 2288篇 |
免费 | 154篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 51篇 |
妇产科学 | 18篇 |
基础医学 | 415篇 |
口腔科学 | 49篇 |
临床医学 | 186篇 |
内科学 | 488篇 |
皮肤病学 | 43篇 |
神经病学 | 253篇 |
特种医学 | 49篇 |
外科学 | 223篇 |
综合类 | 3篇 |
预防医学 | 185篇 |
眼科学 | 20篇 |
药学 | 196篇 |
中国医学 | 6篇 |
肿瘤学 | 244篇 |
出版年
2024年 | 1篇 |
2023年 | 21篇 |
2022年 | 41篇 |
2021年 | 68篇 |
2020年 | 33篇 |
2019年 | 77篇 |
2018年 | 78篇 |
2017年 | 43篇 |
2016年 | 54篇 |
2015年 | 95篇 |
2014年 | 98篇 |
2013年 | 146篇 |
2012年 | 199篇 |
2011年 | 213篇 |
2010年 | 108篇 |
2009年 | 127篇 |
2008年 | 173篇 |
2007年 | 172篇 |
2006年 | 152篇 |
2005年 | 152篇 |
2004年 | 136篇 |
2003年 | 110篇 |
2002年 | 68篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 14篇 |
1998年 | 18篇 |
1997年 | 10篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1992年 | 5篇 |
1987年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有2445条查询结果,搜索用时 46 毫秒
81.
82.
Thierry Atzeni Chantal Henry Isabelle Minois Sébastien Gard Alain Desage Léa Zanouy Katia M'Bailara 《Psychiatry research》2013
To better explore the clinical heterogeneity of bipolar mood states, we developed a dimensional scale for assessing all mood episodes (depressive, hypomanic, manic, mixed states) using the same tool. The Multidimensional Assessment of Thymic States (MATHYS) (Henry et al., 2008) provides two scores, a total score measuring a level of activation and a sub-score of emotional reactivity. The aim of this study was to establish the appropriate cut-off in total activation versus inhibition and in the emotional reactivity sub-score in bipolar disorders. Patients (n=187) during an acute episode and controls (n=89) filled in the MATHYS. Receiver Operating Characteristic (ROC) curves were obtained to estimate the sensitivity and specificity of the global score and the emotional reactivity sub-score of the MATHYS, in order to differentiate patients from controls. ROC curves showed very satisfactory sensitivity and specificity levels both for the total score and the sub-score of emotional reactivity, thus providing an appropriate cut-off. Concerning the total score between 0 and 200, patients with a score lower than 91 had significant global inhibition and those with a score higher than 109 had significant global activation. Regarding the emotional reactivity sub-score between 0 and 40, patients with a score lower than 16 had significant emotional hyporeactivity and those with a score higher than 24 had significant emotional hyperreactivity. Our results provide cut-offs for the MATHYS to identify patients in an acute phase. 相似文献
83.
84.
O’Neill Ellsy Clarke Philip Fido Dean Vione Katia Correa 《International journal of mental health and addiction》2022,20(2):1171-1181
International Journal of Mental Health and Addiction - Defined as the successful adaptation to dynamic environments, resilience is considered a cornerstone of mental health. However, with the... 相似文献
85.
Margherita Gobbo Giulia Ottaviani Katia Rupel Francesca Ciriello Aulo Beorchia Roberto Di Lenarda Serena Zacchigna Matteo Biasotto 《Lasers in medical science》2016,31(3):471-479
Oral mucositis (OM) and radiodermatitis (RD) are serious side effects of radiotherapy (RT), often leading to its suspension, need for analgesics, and enteral/parenteral nutrition. Laser therapy is becoming a recommended treatment option. This prospective study aimed at demonstrating the beneficial effect of class IV laser therapy (HPLT) on RT-induced OM, an off-label use of HPLT to treat RD in breast cancer patients. Fifty-three cancer patients, during/after RT and/or chemotherapy (CT), affected by OM, were treated with HPLT during four consecutive days (970?±?15 nm, 5 W (50 %), 35–6000 Hz, 240 s). Assessment of OM (Grading Objective Scale, WHO-SCALE), pain (visual analogue scale, VAS), functional ability, subjective parameters, and site/severity of OM were recorded over time. Similarly, 27 breast cancer patients affected by RD were treated by HPLT and monitored over time for grade, discomfort, itching, and bleeding. Progressive improvement of WHO-SCALE from day 7 on, and of VAS from day 2 on (p?<?0.000) was registered. All patients’ functional capacity improved on day 4 (p?<?0.05). All subjective parameters improved on day 14 (p?<?0.001) except for voice, which improved on day 21 (p?<?0.000). Ulcerations’ dimension and erythema’s severity significantly decreased in all sites examined (p?<?0.05). Similarly, HPLT proved to be beneficial in managing RD for all the parameters considered (p?<?0.002). Regardless of OM grade/site and of kind/site of tumor, HPLT proved to be effective in healing OM as well as RD. In both cases, effective treatment can improve life quality through a safe, easy, innovative approach. Therefore, HPLT may become an integral part of everyday practice in the management of RT adverse effects. 相似文献
86.
Morphological and functional response to injury to the external urethral sphincter – similarities and differences between male and female rats
下载免费PDF全文
![点击此处可从《Neurourology and urodynamics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
87.
Irene D. Bezemer Katia M. C. Verhamme Rosa Gini Mees Mosseveld Peter R. Rijnbeek Gianluca Trifirò 《The European journal of contraception & reproductive health care》2016,21(1):81-87
Objectives: The aim of the study was to assess the prevalence of oral contraceptive (OC) use, user characteristics and prescribing patterns by accessing health care databases of three European countries.Methods: A retrospective study was performed from 2009 to 2010 in three general practice (GP) databases from the Netherlands, UK and Italy and in one database of linked pharmacy and hospitalisation data in the Netherlands. The presence of selected chronic conditions and diagnoses of diseases associated with OC use were assessed, as were switches, discontinuations and types of OC used during the study period.Results: Among 2.16 million women aged 15 to 49 years, 16.0% were using an OC on 1 January 2010. The prevalence ranged from 19.7% in a Dutch database to 2.6% in the Italian database. During 2009 and 2010, mainly second-generation progestogens were prescribed in the Netherlands (79.4% and 78.3% of users), both second- (57.9%) and third-generation progestogens (43.6%) were prescribed in the UK, and mainly third-generation progestogens in Italy (61.8%). Most switches were to third- or fourth-generation pills. The prevalence of chronic diseases tended to be higher among OC users, and the proportions of women with a history of disease associated with OC use tended to be lower than among non-users.Conclusions: Second-generation OCs were most frequently prescribed in the Netherlands. In the UK, and even more so in Italy, many women used third- or fourth-generation OCs. Preparation switches were mainly to third- or fourth-generation OCs. Among OC users, a somewhat higher prevalence of chronic diseases was observed; however, information bias cannot be ruled out. 相似文献
88.
Henry C M'Baïlara K Desage A Gard S Misdrahi D Vieta E 《Journal of affective disorders》2007,101(1-3):35-41
BACKGROUND: DSM-IV criteria for mixed states may be too restrictive and may actually exclude patients who do not meet the full criteria for a manic and depressive state. Using this DSM-IV definition, many patients who are considered depressed may have mixed features, which can explain why some bipolar depressive states can worsen with antidepressants and can be improved by mood stabilizers or atypical antipsychotics. A dimensional approach not exclusively focused on the tonality of affect would help to define a broader entity of mixed states. The aim of this study was to apply a dimensional model to bipolar episodes and to assess the overlap between the groups defined using this model and using categorical diagnosis. METHOD: We assessed 139 DSM-IV acutely ill bipolar I patients with MAThyS (Multidimensional Assessment of Thymic States by Henry et al. in press), a scale that assesses five quantitative dimensions exploring excitatory and inhibition processes, and that is not focused on tonality of mood but on emotional reactivity. We studied the relationship between clusters defined by statistical analyses and DSM-IV bipolar mood states. RESULTS: This study showed the existence of three clusters. Cluster 1 was characterized by an inhibition in all dimensions and corresponded to the depressive cluster (more than 90% of patients met the criteria for DSM-IV Major Depressive Episode (MDE)). Cluster 2 showed a general excitation and was mainly DSM-IV manic or hypomanic patients (90%). Cluster 3 (Mixed) was more complex and the diagnosis included MDE (56%) in most of the cases associated with manic or hypomanic symptoms, mixed states (18%) defined by DSM-IV criteria, and manic or hypomanic states (25%). Emotional reactivity was relevant to distinguish Cluster 1 (Depressive), exhibiting emotional hypo-reactivity, from Cluster 2 (Manic) and 3 (Mixed), characterized by emotional hyper-reactivity. Sadness was reported equally in all three clusters. CONCLUSION: A dimensional approach using the concept of emotional reactivity seems appropriate to define a broad mixed state entity in patients who would be diagnosed with MDE according to DSM-IV. Further studies are needed to test the relevance of this model in therapeutic strategies. 相似文献
89.
Rapid detection and identification of metallo-beta-lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mendes RE Kiyota KA Monteiro J Castanheira M Andrade SS Gales AC Pignatari AC Tufik S 《Journal of clinical microbiology》2007,45(2):544-547
Metallo-beta-lactamase enzymes (MbetaL) are encoded by transferable genes, which appear to spread rapidly among gram-negative bacteria. The objective of this study was to develop a multiplex real-time PCR assay followed by a melt curve step for rapid detection and identification of genes encoding MbetaL-type enzymes based on the amplicon melting peak. The reference sequences of all genes encoding IMP and VIM types, SPM-1, GIM-1, and SIM-1 were downloaded from GenBank, and primers were designed to obtain amplicons showing different sizes and melting peak temperatures (Tm). The real-time PCR assay was able to detect all MbetaL-harboring clinical isolates, and the Tm-assigned genotypes were 100% coincident with previous sequencing results. This assay could be suitable for identification of MbetaL-producing gram-negative bacteria by molecular diagnostic laboratories. 相似文献
90.
Katia Iglesias Stéphanie Baggio Karine Moschetti Jean-Blaise Wasserfallen Olivier Hugli Jean-Bernard Daeppen Bernard Burnand Patrick Bodenmann 《Quality of life research》2018,27(2):503-513