全文获取类型
收费全文 | 5409篇 |
免费 | 356篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 169篇 |
妇产科学 | 153篇 |
基础医学 | 611篇 |
口腔科学 | 129篇 |
临床医学 | 660篇 |
内科学 | 949篇 |
皮肤病学 | 65篇 |
神经病学 | 410篇 |
特种医学 | 151篇 |
外科学 | 679篇 |
综合类 | 42篇 |
一般理论 | 5篇 |
预防医学 | 615篇 |
眼科学 | 78篇 |
药学 | 355篇 |
中国医学 | 7篇 |
肿瘤学 | 655篇 |
出版年
2023年 | 27篇 |
2022年 | 37篇 |
2021年 | 110篇 |
2020年 | 93篇 |
2019年 | 112篇 |
2018年 | 138篇 |
2017年 | 115篇 |
2016年 | 110篇 |
2015年 | 140篇 |
2014年 | 194篇 |
2013年 | 290篇 |
2012年 | 344篇 |
2011年 | 382篇 |
2010年 | 242篇 |
2009年 | 192篇 |
2008年 | 360篇 |
2007年 | 351篇 |
2006年 | 351篇 |
2005年 | 311篇 |
2004年 | 304篇 |
2003年 | 280篇 |
2002年 | 254篇 |
2001年 | 90篇 |
2000年 | 60篇 |
1999年 | 77篇 |
1998年 | 68篇 |
1997年 | 64篇 |
1996年 | 50篇 |
1995年 | 51篇 |
1994年 | 45篇 |
1993年 | 43篇 |
1992年 | 48篇 |
1991年 | 60篇 |
1990年 | 48篇 |
1989年 | 24篇 |
1988年 | 28篇 |
1987年 | 37篇 |
1986年 | 25篇 |
1985年 | 23篇 |
1984年 | 30篇 |
1983年 | 19篇 |
1982年 | 24篇 |
1981年 | 16篇 |
1980年 | 22篇 |
1979年 | 9篇 |
1978年 | 12篇 |
1977年 | 9篇 |
1975年 | 8篇 |
1974年 | 8篇 |
1967年 | 8篇 |
排序方式: 共有5781条查询结果,搜索用时 15 毫秒
61.
Familial aggregation and heterogeneity of non-Hodgkin lymphoma in population-based samples. 总被引:4,自引:0,他引:4
Lynn R Goldin Ola Landgren Mary L McMaster Gloria Gridley Kari Hemminki Xinjun Li Lene Mellemkjaer J?rgen H Olsen Martha S Linet 《Cancer epidemiology, biomarkers & prevention》2005,14(10):2402-2406
The importance of genetic factors in the etiology of non-Hodgkin lymphoma (NHL) is suggested by case-control and cohort studies. Most previous studies have been too small to estimate accurately risks of specific categories of lymphoproliferative malignancies in relatives of NHL cases or to quantify the contribution of NHL case characteristics to familial risk. We have overcome sample size limitations and potential recall bias by using large databases from Sweden and Denmark. Diagnoses of lymphoproliferative malignancies were compared in 70,006 first-degree relatives of 26,089 NHL cases (including 7,432 with subtype information) versus 161,352 first-degree relatives of 58,960 matched controls. Relatives of NHL cases were at significantly increased risk for NHL [relative risk (RR), 1.73; 95% confidence interval (95% CI), 1.39-2.15], Hodgkin lymphoma (RR, 1.41; 95% CI, 1.0-1.97), and nonsignificantly for chronic lymphocytic leukemia (CLL; RR, 1.31; 95% CI, 0.93-1.85). No increased risk was found for multiple myeloma among case relatives. Findings with respect to siblings compared with parents and offspring or with respect to age at diagnosis of proband were inconsistent. In both populations, relatives of cases with an aggressive NHL subtype were at substantially increased risk of NHL (combined RR, 3.56; 95% CI, 1.80-7.02). We conclude that NHL has an important familial component, which is shared with Hodgkin lymphoma and CLL. We estimate that the absolute lifetime risk for a first-degree relative of an NHL case to develop NHL is 3.6% (compared with a population risk of 2.1%) and higher if the index case had an aggressive subtype of NHL. 相似文献
62.
Ronald Allen Coss Christopher W. Storck Tiffany C. Wells Kari A. Kulp Miriam Wahl Dennis B. Leeper 《International journal of hyperthermia》2014,30(1):75-78
Purpose: This study tested the ability of lonidamine (LND), a clinically applicable inhibitor of monocarboxylate transporters (MCT), to thermally sensitise human melanoma cells cultured at a tumour-like extracellular pH (pHe) 6.7.Materials and methods: Human melanoma DB-1 cells cultured at pHe 6.7 and pHe 7.3 were exposed to 150?µM LND for 3?h, beginning 1?h prior to heating at 42?°C (2?h). Intracellular pH (pHi) was determined using 2′,7′-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (BCECF) and whole spectrum analysis. Levels of heat shock proteins (HSPs) were determined by immunoblot analysis. Cell survival was determined by colony formation.Results: Treatment with LND at pHe 6.7 reduced pHi to 6.30?±?0.21, reduced thermal induction of HSPs, and sensitised cells growing at pHe 6.7 to 42?°C. When LND was combined with an acute acidification from pHe 6.7 to pHe 6.5, pHi was reduced to 6.09?±?0.26, and additional sensitisation was observed. LND had negligible effects on cells cultured at pH 7.3.Conclusions: The results show that LND can reduce pHi in human melanoma cells cultured at a tumour-like low pHe so that the 42?°C induction of HSPs are abrogated and the cells are sensitised to thermal therapy. Cells cultured at a normal tissue-like pHe 7.3 were not sensitised to 42?°C by LND. These findings support the strategy that human melanoma cells growing in an acidic environment can be sensitised to thermal therapy in vivo by exposure to an MCT inhibitor such as LND. 相似文献
63.
Patricia Leahy‐Warren PhD MSc BSc Hdip PHN RPHN RM RGN Mary Rose Day DN MA BSc Hdip PHN RPHN RM RGN Kari Glavin PhD M.Sc PHN RN MEANS Edith Roth Gjevjon PhD MSc RN MEANS Anne Kjersti Myhrene Steffenak PhD MSc PHN RN Live S. Nordhagen MSc PHN RN Hilde Egge MSc PHN RN Elizabeth Healy MSc PHN RGN 《Public health nursing (Boston, Mass.)》2018,35(4):307-316
64.
65.
66.
67.
Olöf Birna Kristjansdottir André Vågan Margrét Hrönn Svavarsdóttir Hilde Blindheim Børve Kari Hvinden Veerle Duprez Ann Van Hecke Lena Heyn Hilde Strømme Una Stenberg 《Patient education and counseling》2021,104(5):1030-1048
ObjectivesTo provide overview of research on training interventions for healthcare providers aimed at promoting competencies in delivering group-based patient education.MethodsA systematic literature search identified relevant studies. Data was extracted on training details, study design, outcomes and experiences. Results were summarized and qualitative data analyzed using content analysis.ResultsTwenty-seven studies exploring various training interventions were included. Ten studies used qualitative methods, eight quantitative and nine mixed methods. Use of a comparison group, validated instruments and follow-up measures was rare. Healthcare providers’ reactions to training were mostly positive. Several studies indicated positive short-term effects on self-efficacy and knowledge. Results on observed skills and patient outcomes were inconclusive. Results on healthcare providers’ experience of delivery of group-based patient education following training were categorized into 1) Benefits of training interventions, 2) Barriers to implementation and 3) Delivery support.ConclusionsFurther evaluation of training for healthcare providers delivering group-based patient education is needed before conclusions on training efficacy can be drawn. The results indicate an expanding research field still in maturation.Practice implicationsEfficacy studies evaluating theoretically grounded training with clear attention on group facilitation and follow-up support are needed. Inclusion of validated instruments and long-term outcomes is encouraged. 相似文献
68.
69.
70.