收费全文 | 1379059篇 |
免费 | 105137篇 |
国内免费 | 4374篇 |
耳鼻咽喉 | 17319篇 |
儿科学 | 45334篇 |
妇产科学 | 37585篇 |
基础医学 | 203383篇 |
口腔科学 | 36539篇 |
临床医学 | 137344篇 |
内科学 | 265776篇 |
皮肤病学 | 26865篇 |
神经病学 | 116373篇 |
特种医学 | 49153篇 |
外国民族医学 | 367篇 |
外科学 | 187909篇 |
综合类 | 29258篇 |
现状与发展 | 1篇 |
一般理论 | 542篇 |
预防医学 | 121211篇 |
眼科学 | 29601篇 |
药学 | 101443篇 |
6篇 | |
中国医学 | 3210篇 |
肿瘤学 | 79351篇 |
2021年 | 11874篇 |
2019年 | 12672篇 |
2018年 | 17562篇 |
2017年 | 13196篇 |
2016年 | 14225篇 |
2015年 | 16294篇 |
2014年 | 22350篇 |
2013年 | 34473篇 |
2012年 | 47602篇 |
2011年 | 50460篇 |
2010年 | 29059篇 |
2009年 | 26699篇 |
2008年 | 45839篇 |
2007年 | 48263篇 |
2006年 | 48354篇 |
2005年 | 46668篇 |
2004年 | 44351篇 |
2003年 | 42070篇 |
2002年 | 40814篇 |
2001年 | 61160篇 |
2000年 | 62802篇 |
1999年 | 52611篇 |
1998年 | 15095篇 |
1997年 | 13662篇 |
1996年 | 13445篇 |
1995年 | 12723篇 |
1994年 | 11921篇 |
1993年 | 11197篇 |
1992年 | 41744篇 |
1991年 | 40907篇 |
1990年 | 39584篇 |
1989年 | 37482篇 |
1988年 | 34713篇 |
1987年 | 33810篇 |
1986年 | 32292篇 |
1985年 | 30774篇 |
1984年 | 23178篇 |
1983年 | 19713篇 |
1982年 | 11916篇 |
1979年 | 20873篇 |
1978年 | 14894篇 |
1977年 | 12149篇 |
1976年 | 11939篇 |
1975年 | 12183篇 |
1974年 | 14864篇 |
1973年 | 14531篇 |
1972年 | 13405篇 |
1971年 | 12449篇 |
1970年 | 11512篇 |
1969年 | 10442篇 |
Methods: Tumour and surrounding tissue were modeled by elliptical two- and three-dimensional computational phantoms having six different nanoparticle distributions. Nanoparticles were modeled as point heat sources having amplitude-dependent loss power. The total number of nanoparticles was fixed, and their spatial distribution and heat output were varied. Heat transfer was computed by solving the Pennes’ bioheat equation using finite element methods (FEM) with temperature-dependent blood perfusion. Local temperature was regulated using a proportional-integral-derivative (PID) controller. Tissue temperature, thermal dose and tissue damage were calculated. The required minimum thermal dose delivered to the tumor was kept constant, and heating power was adjusted for comparison of both the heating methods.
Results: Modulated power heating produced lower and more homogeneous temperature distributions than did constant power heating for all studied nanoparticle distributions. For a concentrated nanoparticle distribution, located off-center within the tumor, the maximum temperatures inside the tumor were 16% lower for modulated power heating when compared to constant power heating. This resulted in less damage to surrounding normal tissue. Modulated power heating reached target thermal doses up to nine-fold more rapidly when compared to constant power heating.
Conclusions: Controlling the temperature at the tumor-healthy tissue boundary by modulating the heating power of magnetic nanoparticles demonstrably compensates for a variable nanoparticle distribution to deliver effective treatment. 相似文献
Aims
To examine the influence of pre-existing psychiatric disorder on the choice of treatment in patients with gynaecological cancer.Materials and methods
The analyses were based on all patients who underwent surgical treatment for endometrial, ovarian or cervical cancer who were registered in the Danish Gynecological Cancer Database in the years 2007–2014 (3059 patients with ovarian cancer, 5100 patients with endometrial cancer and 1150 with cervical cancer). Logistic regression model and Cox regression model, adjusted for relevant confounders, were used to estimate the effect of pre-existing psychiatric disorder on the course of cancer treatment. Our outcomes were (i) presurgical oncological treatment, (ii) macroradical surgery for patients with ovarian cancer, (iii) radiation/chemotherapy within 30 days and 100 days after surgery and (iv) time from surgery to first oncological treatment.Results
In the group of patients with ovarian cancer, more patients with a psychiatric disorder received macroradical surgery versus patients without a psychiatric disorder, corresponding to an adjusted odds ratio of 1.24 (95% confidence interval 0.62–2.41) and the chance for having oncological treatment within 100 days was odds ratio = 1.26 (95% confidence interval 0.77–2.10). As for patients with endometrial cancer, all outcome estimates were close to unity. The adjusted odds ratio for oncological treatment within 30 days after surgery in patients with cervical cancer with a history of psychiatric disorder was 0.20 (95% confidence interval 0.03–1.54).Conclusions
We did not find any significant differences in the treatment of ovarian and endometrial cancer in patients with pre-existing psychiatric diagnoses. When it comes to oncological treatment, we suggest that increased attention should be paid to patients with cervical cancer having a pre-existing psychiatric diagnosis. 相似文献- Download : Download high-res image (228KB)
- Download : Download full-size image