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991.
Rescue of implantation potential in embryos with poor prognosis by assisted zona hatching 总被引:17,自引:7,他引:10
Magli MC; Gianaroli L; Ferraretti AP; Fortini D; Aicardi G; Montanaro N 《Human reproduction (Oxford, England)》1998,13(5):1331-1335
The effect of the assisted zona hatching (AZH) procedure was investigated
on 135 cycles with a poor prognosis of pregnancy due to: (i) maternal age
> or = 38 years (45 cycles); (ii) three or more failed in-vitro
fertilization (IVF) attempts (70 cycles), and (iii) patients possessing
both inclusion criteria (20 cycles). The control groups (113 cycles)
included patients possessing the same characteristics (42, 53 and 18 cycles
respectively) and who did not undergo the AZH procedure. A total of 505
embryos was treated with AZH before transfer, resulting in: 14, 25 and 6
clinical pregnancies. The percentage of clinical pregnancies per cycle was
significantly higher than controls for the first (31 vs 10% in control 1, P
< 0.05) and second groups (36 vs 17% in control 2, P < 0.05). No
significant difference in percentage of clinical pregnancies was found for
the third group (30 vs 6%). Similarly, higher rates of implantation were
obtained (11.5, 15 and 11%) compared to the respective controls (4%, P <
0.02; 6.3%, P < 0.01; and 1.5%). The rate of miscarriage in the AZH
groups was similar to that obtained in the controls (22 vs 21%). Finally,
the morphological analysis of the embryos transferred revealed that the
poor prognosis condition is associated to a significantly slower rate of
development and a higher rate of fragmentation. The present results
indicate that AZH procedure improves pregnancy and implantation rates in
patients with a poor prognosis of pregnancy by facilitating the hatching
process in embryos which would otherwise be trapped inside the zona
pellucida.
相似文献
992.
993.
Colostrum has important anti-infective properties. It may also somehow promote the development of the child's immunological system. Discarding colostrum, as practised in some cultures, could thus have adverse health consequences beyond the neonatal period. To test this hypothesis, the age at breast feeding start of 734 healthy newborns in urban Guinea-Bissau was ascertained. The children were then prospectively followed up to 3 years of age. Eighty nine deaths occurred during the study. The probability of death in the age interval 28 days to 3 years was about 20%. The child's age at breast feeding start had no statistical impact on postneonatal growth or survival. As a single measure, early breast feeding start is not likely to make much difference for the long term growth or survival of children living under material poverty conditions. 相似文献
994.
995.
CYP2D6和GST在白种人晚期肾病中的遗传变异 总被引:1,自引:0,他引:1
目的生物转化酶细胞色素P4502D6(CYP2D6)和谷胱苷肽转移酶-M1(GST-M1)、谷胱苷肽转移酶-T1(GST-T1)共同代谢内源性和外源性毒素,一部分人群由于相应基因变异导致这些酶缺乏表达,我们检测白种人群中晚期肾病(ESRD)病人这些酶的基因多态性是否比健康者有较高的频率.方法从列克星顿及周围地区征募330名晚期肾病病人和303名健康者,均为白种人,给予他们进行CYP2D6和GST-M1和T1基因分型.结果在ESRD病人中CYP2D6和GST-M1和GST-T1以及CYP2D6和GST-M1或GST-T1都缺乏分别为2.1%和4.2%;而在健康者中均为0.3%(P<0.01).结论CYP2D6和GST-M1和/或GST-T1酶缺乏在ESRD病人中有较高的频率,提示这些酶缺乏可以预计慢性肾病进展的可能性. 相似文献
996.
997.
Remy-Jardin M; Duyck P; Remy J; Petyt L; Wurtz A; Mensier E; Copin MC; Riquet M 《Radiology》1995,196(2):387
998.
MARK R. STEIN M.D. Maj MC USA CARLTON K. THOMPSON Jr. M.D. Maj MC USA †JOHN E. SAWICKI M.D. Maj MC USA ‡ANTHONY J. MARTEL M.D. Maj MC USA ‡ 《The American journal of gastroenterology》1974,62(5):435-439
Esophageal stricture may occur as a late complication of the Stevens-Johnson syndrome. Our patient suffered multiple complications, including bilateral blindness and developed significant dysphagia two months after the onset of the Stevens-Johnson syndrome. Early radiologic and endoscopic documentation of the stricture of the distal esophagus led to the initiation of treatment with esophageal dilatation. A program of esophageal dilatation and antacid therapy was successful in relieving the dysphagia and in returning the patient to her normal diet. With early diagnosis and treatment of esophageal stricture surgical intervention may be avoided. 相似文献
999.
Clyde A. Helms M.D. Gregory S. Chapman CPT USAF MC James H. Wild LTC USAF MC 《Skeletal radiology》1981,7(1):55-58
Two cases of Charcot-like joints in patients with pseudogout who were otherwise neurologically intact are presented. The arthropathy of pseudogout should include Charcot-like joints and it is emphasized that an apparent Charcot joint should raise the question of pseudogout. 相似文献
1000.