全文获取类型
收费全文 | 5790篇 |
免费 | 316篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 77篇 |
儿科学 | 89篇 |
妇产科学 | 88篇 |
基础医学 | 802篇 |
口腔科学 | 168篇 |
临床医学 | 420篇 |
内科学 | 1287篇 |
皮肤病学 | 185篇 |
神经病学 | 433篇 |
特种医学 | 284篇 |
外科学 | 864篇 |
综合类 | 24篇 |
一般理论 | 2篇 |
预防医学 | 266篇 |
眼科学 | 130篇 |
药学 | 514篇 |
中国医学 | 8篇 |
肿瘤学 | 501篇 |
出版年
2023年 | 24篇 |
2022年 | 69篇 |
2021年 | 159篇 |
2020年 | 84篇 |
2019年 | 121篇 |
2018年 | 139篇 |
2017年 | 100篇 |
2016年 | 122篇 |
2015年 | 125篇 |
2014年 | 163篇 |
2013年 | 224篇 |
2012年 | 327篇 |
2011年 | 400篇 |
2010年 | 228篇 |
2009年 | 186篇 |
2008年 | 317篇 |
2007年 | 385篇 |
2006年 | 366篇 |
2005年 | 336篇 |
2004年 | 295篇 |
2003年 | 257篇 |
2002年 | 298篇 |
2001年 | 147篇 |
2000年 | 133篇 |
1999年 | 146篇 |
1998年 | 68篇 |
1997年 | 53篇 |
1996年 | 51篇 |
1995年 | 38篇 |
1994年 | 34篇 |
1993年 | 23篇 |
1992年 | 76篇 |
1991年 | 39篇 |
1990年 | 55篇 |
1989年 | 55篇 |
1988年 | 61篇 |
1987年 | 54篇 |
1986年 | 51篇 |
1985年 | 56篇 |
1984年 | 24篇 |
1983年 | 25篇 |
1982年 | 15篇 |
1979年 | 23篇 |
1978年 | 20篇 |
1977年 | 16篇 |
1976年 | 16篇 |
1975年 | 13篇 |
1974年 | 18篇 |
1973年 | 13篇 |
1972年 | 13篇 |
排序方式: 共有6142条查询结果,搜索用时 46 毫秒
21.
22.
J Tamaru A Mikata H Horie K Itoh T Asai R Hondo S Mori 《The American journal of surgical pathology》1990,14(6):571-577
We report two cases of herpes simplex lymphadenitis without widespread organ involvement in a 60-year-old man and a 67-year-old woman. Their complaints were high fever and generalized erythema followed after few days by generalized lymphadenopathy. This report describes the findings obtained by light and electron microscopy, immunohistochemistry, and in situ hybridization. In both instances, Cowdry's type A intranuclear inclusion bodies were found in T-immunoblasts in the background of T-zone hyperplasia with focal necrosis. Electron microscopic investigation revealed intranuclear and cytoplasmic virus particles with characteristics of the herpes group. Immunohistochemical staining utilizing anti-herpes simplex virus (HSV) antibody was positive and in situ hybridization with HSV-DNA probe revealed positive signals in the nucleus and in the cytoplasm of T-immunoblasts. Although rare, HSV lymphadenitis in the absence of generalized infection can occur. 相似文献
23.
Asai T.; McBeth C.; Stewart JIM.; Williams J.; Vaughan R. S.; Power I. 《British journal of anaesthesia》1997,78(1):28-33
We have investigated the effects of clonidine on gastric emptying of
liquids in 30 patients. In a double-blind, randomized design, clonidine 150
micrograms, morphine 10 mg or saline in 1 ml was given i.m. One hour later,
the patient drank a paracetamol solution (1.5 g in 50 ml water). Venous
blood samples were obtained every 15 min for 90 min thereafter. Plasma
paracetamol concentrations were measured using high- pressure liquid
chromatography and the area under the concentration- time curve was
calculated. The degree of sedation and complications were recorded. The
area under the curve for 0-60 min was significantly smaller in the morphine
group than in the saline group (P = 0.002; 95% confidence interval (CI) for
difference -1237 to -502 micrograms min ml- 1), whereas it was greater in
the clonidine group compared with the saline group, although this was not
significant (95% CI for difference - 423 to 1264 micrograms min ml-1).
Arterial pressure was significantly lower in the clonidine group compared
with the saline group. Both clonidine and morphine appeared to cause mild
sedation. We conclude that clonidine 150 micrograms i.m. does not delay
gastric emptying of liquids in a similar manner to morphine.
相似文献
24.
25.
Growth fractions of transitional cell carcinomas of the bladder defined by the monoclonal antibody Ki-67 总被引:4,自引:0,他引:4
We used an immunohistochemical technique with the monoclonal antibody Ki-67, which recognizes nuclear antigen expressed in proliferating cells to determine the growth fractions of 5 normal mucosa specimens and 55 transitional cell carcinomas of the bladder. Normal mucosa had a mean value of 0.37 +/- 0.35% cells positive for Ki-67, whereas 9 histological grade 1 tumors showed 2.2 +/- 1.5%, 31 grade 2 tumors averaged 10.1 +/- 7.5% and 15 grade 3 tumors yielded 19.5 +/- 9.0%. These values were significantly different from each other (p less than 0.01), with Ki-67 indexes for grade 2 varying from 0.3 to 24.6%. Nonpapillary tumors had significantly higher indexes than papillary tumors (20.1 +/- 8.0 versus 6.7 +/- 5.9, p less than 0.01). The Ki-67 indexes were 4.6 +/- 4.5% for stage Ta (20 cases), 7.8 +/- 4.7% for stage T1 (14) and 20.2 +/- 7.8% for stages equal to or higher than T2 (21). Significant differences were noted between stages Ta and T1 (p less than 0.05) and between stages T1 and T2 or greater (p less than 0.01). Tumors with muscle layer invasion often showed more than 15% Ki-67 positive cells. Our results imply that Ki-67 indexes not only provide objective information to determine a malignant potential but also help to select the treatment. 相似文献
26.
Kazuki Sato Toshiyasu Nakamura Yoshiaki Toyama Hiroyasu Ikegami Kaori Kameyama Shinichiro Takayama 《Hand surgery》2007,12(3):149-154
Calcium deposition in the skin, known as calcinosis cutis, is an uncommon disorder caused by an abnormal deposit of calcium phosphate in the skin. We report a case of idiopathic calcinosis cutis in fingertip treated with surgical excision followed by the occlusive dressing using aluminum foil, and obtained significant pain relief and round-shaped fingertip which looked normal. 相似文献
27.
We conducted a prospective survey on the incidence of respiratory
complications associated with tracheal intubation and extubation in 1005
patients who underwent elective general anaesthesia over a 4-month period.
During induction of anaesthesia, respiratory complications occurred in 46
patients (4.6%; 95% confidence limits (CL): 3.3, 5.9%). The common
complications were coughing (1.5%) and difficult ventilation through a
facemask (1.4%). Tracheal intubation was difficult in eight patients
(0.8%). Complications occurred immediately after tracheal extubation in 127
patients (12.6%; 95% CL: 10.6, 14.7) and in the recovery room in 95
patients (9.5%; 95% CL: 7.6, 11.3%). The common complications immediately
after extubation were coughing (6.6%) and oxygen desaturation (SaO2 <
90%) (2.4%), and in the recovery room, airway obstruction (3.8%) and
coughing (3.1%). The incidence of complications was significantly higher
immediately after tracheal extubation than during induction of anaesthesia
(P << 0.001). Even when all incidents of coughing that occurred after
tracheal extubation were disregarded as a complication, the overall
incidence was still higher immediately after extubation (7.4%) than during
induction of anaesthesia (P < 0.01). We conclude that the incidence of
respiratory complications associated with tracheal extubation may be higher
than that during tracheal intubation.
相似文献
28.
T Kawashima H Ajiki Y Asai H Nakakura S Komatsu 《Kyobu geka. The Japanese journal of thoracic surgery》1989,42(12):1009-1011
Two cases underwent a modified Fontan operation with simultaneous superior vena cava-right pulmonary artery end-to-side anastomosis, which we called "bidirectional Glenn shunt". This anastomosis seems to be so effective for reduction of right arterial volume loading, and could proved life-saving in the case with the acute obstruction at the site of the right atriopulmonary artery anastomosis immediately after surgery. 相似文献
29.
Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells 总被引:3,自引:0,他引:3
Hirota Y Osuga Y Hirata T Harada M Morimoto C Yoshino O Koga K Yano T Tsutsumi O Taketani Y 《Human reproduction (Oxford, England)》2005,20(12):3547-3553
BACKGROUND: Inflammation has been proposed to play essential roles in the pathophysiology of endometriosis, in which neutrophils and mast cells have been suggested to be involved. We studied whether the protease-activated receptor 2 (PAR2), which is activated by enzymes from neutrophils and mast cells, in endometriotic stromal cells (ESC) has any implication in the development of the disease. METHODS: Cultured ESC were stimulated with various concentrations of a specific PAR2 agonist peptide. Proliferating activity of the cells was determined using immunostaining of proliferating cell nuclear antigen (a cell proliferation marker), 5-bromo-2'-deoxyuridine incorporation into DNA and cell count. The concentrations of interleukin (IL)-6 and IL-8 were measured using specific enzyme-linked immunosorbent assay kits. The phosphorylation of three mitogen-activated protein kinases (MAPK), i.e. p38 MAPK, p42/44 MAPK and stress-activated protein Kinase/c-jun N terminal Kinase, in ESC was examined with Western blot analysis. RESULTS: Activation of PAR2 stimulated the proliferation of ESC and the secretion of IL-6 and IL-8 from ESC in a dose-dependent manner. Activation of PAR2 stimulated the phosphorylation of all three MAPK, and inhibitors of each MAPK suppressed the PAR2 activation-induced proliferation of ESC. CONCLUSIONS: The activation of PAR2 in ESC may be involved in the pathophysiology of endometriosis by inducing the growth and inflammation of endometriotic lesions. 相似文献
30.
Aleksey I. Kovalev Kazuhiko Takeuchi Alexander V. Barzykin Michihiko Asai Mitsuru Ueda Alexander L. Rusanov 《Macromolecular chemistry and physics.》2005,206(20):2112-2121
Summary: The polycondensation of 1‐ethynyl‐2,5‐dihexyl‐4‐iodobenzene in the presence of 1‐ethynyl‐2,5‐dihexyl‐4‐(2‐phenylethynyl)benzene proceeds according to the mechanism of initiated chain growth polycondensation. It has allowed the synthesis of oligomers with a desired molecular weight and a narrow molecular weight distribution. The reasons for the side reaction leading to the formation of diyne compounds are revealed and the presumed mechanism is given. This opens prospects for the preparation of defectless poly(p‐phenyleneethynylene)s with required molecular weights and narrow molecular weight distributions.