The effects of trunk stabilization exercise on bone density after menopause

[Purpose] This study examined the effect of low intensity exercise on bone density by conducting trunk stabilization exercise on females after menopause for 24 weeks. [Subjects and Methods] Thirty three female subjects over 47 years old and under the age of 53 were selected and 16 for experimental group and 17 for control group were randomly selected. Experimental group had performed spinal and pelvic stabilization exercise 30 minutes a day, 5times a week, for 24 weeks. Except for the daily life, control group did not participate in any characteristic movement. Bone density of every member in experimental group was measured using average value of bone density of 1st–4th lumbar through quantitative computer tomography. [Results] There was a meaningful difference in only control group about measured value of bone density within each group, experimental and control group, but there was no meaningful difference in measured value of bone density between two groups, experimental group and control group. [Conclusion] Through this research, we could see the fact that although trunk stability exercise could not change bone density meaningfully, it could maintain bone density. In the future, it is randomly necessary to study things related this because results of researches can show different results according to exercise intensity, exercise period, age, weight, hormone status and mediation period. It is considered that it will help to prevent and treat patients with osteoporosis a lot.Key words: Bone mineral density, Computer tomography, Low intensity exercise     

Effect of constrained weight shift on the static balance and muscle activation of stroke patients

[Purpose] The purpose of this study was to evaluate the effects of constrained weight shift induced by shoe lift beneath the unaffected lower extremity, on balance functions and electromyography of the affected lower extremity of stroke patients. [Subjects and Methods] Twelve patients with unilateral stroke were recruited as volunteers for this study. The subjects were repeatedly measured in a randomized order under three conditions: no-shoe lift, and shoe lifts of 5 mm and 10 mm heights beneath the unaffected lower extremity. [Results] Standing with a 10 mm shoe lift for the unaffected lower extremity decreased the mean velocity of mediolateral sway compared to no-shoe lift. Regarding the velocity of anteroposterior sway, standing with 5 mm and 10 mm shoe lifts decreased the mean velocity of anteroposterior sway. The muscle activation of the affected lower extremity was not significantly different among the no-shoe lift, 5 mm shoe lift and 10 mm shoe lift conditions; however, the muscle activities of the rectus femoris, biceps femoris, tibialis anterior, and medial gastrocnemius of the affected lower extremity progressively improved with increasing height of the shoe lift. [Conclusion] A constrained weight shift to the affected side elicited by a shoe insole of 10 mm height on the unaffected side can improve the static standing balance of stroke patients, and it resulted in 14–24% increases in the muscle activities of the affected leg.Key words: Constrained weight shift, Stroke, Balance     

MLL‐ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia

We report an extremely rare case of acute myelomonocytic leukemia (M4) with an MLL‐ELL fusion gene lacking the PML‐RARα rearrangement that transformed from hypergranular acute promyelocytic leukemia (APL) without showing any karyotypic evolution. The treatment was effective with chemotherapy for M4 and idarubicin plus a cytarabine‐based chemotherapy protocol without ATRA.     

A novel mutation of SETBP1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia

To investigate an oncogenic mutation of SETBP1 in the evolution from acute myelomonocytic leukemia (M4) to secondary aCML. Clinical data and molecular studies were analyzed of paired aCML and 'normal'DNA from a case with M4. We identified a mutation in SETBP1 (encoding a p.Asp868Ala alteration). The analysis of paired sample indicated that SETBP1 mutation was acquired during leukemic evolution.     

基于生物信息学筛选炎症相关结直肠癌基因及其特征分析

目的通过对炎症性肠病差异基因的筛选以及结直肠癌队列生存特征和表达模式的探究,为炎症相关结直肠癌的发生与发展的后续研究提供候选基因。 方法从GEO数据库中选择RNA测序表达谱数据集GSE95473和GSE107597,通过常规转录组表达谱差异分析,筛选出炎症性肠病差异表达基因（DEG）,利用GO数据库获取DEG的功能注释,并利用KEGG数据库进行通路富集分析。同时基于TCGA数据库进一步在结直肠癌数据集中筛选具有预后意义的基因,并评价其在结直肠肿瘤中的表达特征。 结果两个数据集筛选到了共有DEGs 100个,通过主成分分析证实这些基因能够对结直肠癌肿瘤和黏膜区分良好。进一步筛选,获得ALDOB,SPINK4,REG4,IL1B,C2CD4A,CXCL8,NOS2,CXCL3等候选基因。这些基因在结直肠肿瘤中高表达,并且这些基因的高表达往往提示患者预后较好。 结论ALDOB,SPINK4,REG4,IL1B,C2CD4A,CXCL8,NOS2,CXCL3可能在炎症相关结直肠癌的发生发展中发挥重要作用,有待于后续炎癌转化相关功能验证和机制探究。     

CHADS2评分及改良CHADS评分对心房颤动消融术后复发的预测价值

目的：探讨心力衰竭高血压、年龄、糖尿病和脑卒中（包括一过性脑缺血）（CHADS2）评分及改良CHADS评分对心房颤动（房颤）射频消融术后复发的预测价值。方法对2010年7月至2012年3月在我院行射频消融术的93例房颤患者追踪随访12个月,术后1,3,6,9,12个月行12导联心电图或长程心电图检查,结合临床症状及心电图检查结果将其分为复发组（n＝40）和未复发组（n＝53）,采用单因素和多因素分析消融术后房颤复发的危险因素。结果93例房颤患者中持续性房颤35例（37.63%）,随访12个月时复发40例（43.01%）。房颤复发组与未复发组在平均年龄（P＜0.01）、年龄＞70岁（P＜0.05）、病史（P＜0.05）、房颤类型（P＜0.01）、左房内径（P＜0.001）、左室射血分数（P＜0.05）、血细胞比容（P＜0.05）、是否伴心力衰竭（P＜0.05）、是否伴高血压（P＜0.01）、是否伴糖尿病（P＜0.05）、是否有一过性脑缺血或脑卒中史（P＜0.05）、术后是否服用血管紧张素转换酶抑制剂和血管紧张素Ⅱ受体拮抗剂（ACEI/ARB,P＜0.01）、术后是否服用Ⅲ类抗心律失常药（P＜0.05）、CHADS2评分≥1（P＜0.001）等方面差异有统计学意义。logistic回归分析发现,病史、房颤类型、左房内径、CHADS2评分≥1为房颤术后复发的独立危险因素（病史长短：OR＝1.16,P＝0.020;左房内径：OR＝1.17,P＝0.025;房颤类型：OR＝3.34,P＝0.050;CHADS2评分≥1：OR＝5.93,P＝0.019）。进一步分析发现,CHADS2评分≥2、改良CHADS评分≥1、改良CHADS评分≥2亦为房颤术后复发的独立危险因素（CHADS2≥2：OR＝5.42,P＝0.028;改良CHADS评分≥1：OR＝6.64,P＝0.015;改良CHADS评分≥2：OR＝7.32,P＝0.002）。截断点分析显示,CHADS2与改良CHADS均≥1时对房颤消融预后的预测价值最高,对CHADS2评分≥1与改良CHADS评分≥1预测房颤消融预后的灵敏度、特异度、曲线下面积进行比较发现,差异均无统计学意义[分别为0.775 vs 0.800、0.358 vs 0.377、0.708（95%CI 0.601～0.806） vs 0.711（95%CI 0.605～0.818）,均P＞0.05]。结论病史长短、左房内径、房颤类型、CHADS2评分≥1、CHADS2评分≥2、改良CHADS评分≥1、改良CHADS评分≥2均为心房颤动消融术后复发的独立危险因素,且改良CHADS评分与CHADS2评分对房颤消融预后具有同等的预测价值。     

老年重度烧伤合并糖尿病患者的护理效果观察

目的探索对老年重度烧伤合并糖尿病患者实施护理产生的临床效果。方法在该院筛选出68例老年重度烧伤合并糖尿病患者,时间选为2016年5月—2018年5月,使用抽签法对68例患者进行分组,各34例。实施一般护理为对照组,在一般护理基础上实施优化护理为实验组,观察两组产生的护理效果,并对护理后老年日后生活质量进行评估。结果对比两组护理总有效率,实验组高于对照组,差异有统计学意义(P<0.05);对两组护理前后生活质量进行分析,护理前两组数据差异无统计学意义(P>0.05),护理后两组都有显著改善,但实验组优于对照组,差异有统计学意义(P<0.05)。结论对老年重度烧伤并糖尿病患者实施优化护理临床效果更佳,可以促进其早日恢复,提升了日后生活质量,值得临床推广与应用。