全文获取类型
收费全文 | 329篇 |
免费 | 6篇 |
专业分类
儿科学 | 100篇 |
妇产科学 | 1篇 |
基础医学 | 15篇 |
临床医学 | 8篇 |
内科学 | 62篇 |
皮肤病学 | 2篇 |
神经病学 | 13篇 |
特种医学 | 49篇 |
外科学 | 10篇 |
预防医学 | 10篇 |
眼科学 | 1篇 |
药学 | 2篇 |
肿瘤学 | 62篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 6篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 7篇 |
2014年 | 3篇 |
2013年 | 4篇 |
2012年 | 11篇 |
2011年 | 6篇 |
2010年 | 3篇 |
2009年 | 9篇 |
2008年 | 4篇 |
2007年 | 16篇 |
2006年 | 17篇 |
2005年 | 23篇 |
2004年 | 8篇 |
2003年 | 19篇 |
2002年 | 11篇 |
2001年 | 16篇 |
2000年 | 15篇 |
1999年 | 16篇 |
1998年 | 6篇 |
1997年 | 5篇 |
1996年 | 8篇 |
1995年 | 4篇 |
1994年 | 6篇 |
1993年 | 7篇 |
1992年 | 15篇 |
1991年 | 9篇 |
1990年 | 10篇 |
1989年 | 9篇 |
1988年 | 10篇 |
1987年 | 10篇 |
1986年 | 10篇 |
1985年 | 2篇 |
1984年 | 5篇 |
1982年 | 1篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1974年 | 4篇 |
1972年 | 1篇 |
排序方式: 共有335条查询结果,搜索用时 21 毫秒
71.
Muluken Gizaw Donald Maxwell Parkin Ole Stöter Anne Korir Bakarou Kamate Biying Liu Lamin Bojang Guy N'Da Shyam S. Manraj Phiona Bukirwa Eric Chokunonga Tatenda Chingonzoh Jean-Félix Peko Anne Finesse Nontuthuzelo Somdyala Akinade Ladipo Eva Johanna Kantelhardt 《International journal of cancer. Journal international du cancer》2023,152(7):1328-1336
Ovarian cancer (OC) is one of the commonest cancers of women in sub-Saharan Africa (SSA), although to date no data have been available on time trends in incidence to better understand the disease pattern in the region. We estimate time trends by histological subtype from 12 population-based cancer registries in 11 countries: Kenya (Nairobi), Mauritius, Seychelles, Uganda (Kampala), Congo (Brazzaville), Zimbabwe (Bulawayo and Harare), Cote d'Ivoire (Abidjan), The Gambia, Mali (Bamako), Nigeria (Ibadan) and South Africa (Eastern Cape). The selected registries were those that could provide consistent estimates of the incidence of ovarian cancer and with quality assessment for periods of 10 or more years. A total of 5423 cases of OC were included. Incidence rates have been increasing in all registries except Brazzaville, Congo, where a nonsignificant decline of 1% per year was seen. Statistically significant average annual increases were seen in Mauritius (2.5%), Bamako (5.3%), Ibadan (3.9%) and Eastern Cape (8%). Epithelial ovarian cancer was responsible for the increases observed in all registries. Statistically significant average annual percentage changes (AAPC) for epithelial OC were present in Bamako (AAPC = 5.9%), Ibadan (AAPC = 4.7%) and Eastern Cape (AAPC = 11.0%). Creating awareness among professionals of the growing importance of the disease is surely an important step to improving availability of, and access to, diagnosis and treatment of OC in SSA. Support must be given to the cancer registries to improve the availability of good-quality data on this important cancer. 相似文献
72.
Entz-Werle N Gaub MP Lavaux T Marcellin L Metzger N Marec-Berard P Schmitt C Brugiere L Kalifa C Tabone MD Pacquement H Gentet P Lutz P Oudet P Babin A 《International journal of cancer. Journal international du cancer》2007,120(11):2510-2516
In our previous study, a frequent rearrangement at 4q12 has been identified by allelotyping in our large and homogeneous population of pediatric osteosarcomas and it was significantly linked to c-kit protein overexpression. To confirm and understand the involvement of KIT in this tumor, the next step of the study was designed to detect the potential mutations of KIT gene by sequencing the frequently mutated exons 6, 8, 10, 11, 13, 17 and 21 and, in case of unmutated samples, to confirm the genomic amplifications of the wild-type receptor by real-time quantitative PCR (QPCR). A new microsatellite and QPCR targeting PDGFRA was also added to check the accuracy of the 4q11-12 locus. These techniques were performed in 74 pediatric high-grade osteosarcomas treated with the OS94 protocol. Surprisingly, no mutations were found, but, only DNA amplification of KIT gene in the entire population. PDGFRA gene QPCR revealed an unexpected result of predominant deletions in the rearranged tumors. All these results confirm the major role of the 4q11-12 locus and specifically the involvement of c-kit wild-type receptor overexpression in pediatric osteosarcomas and leads us to believe that inhibitors targeting this receptor could have a therapeutic effect in a selected group of patients. 相似文献
73.
Jrme Kalifa MD Matthew Klos BS Sharon Zlochiver PhD Sergey Mironov PhD Kazuhiko Tanaka MD Netha Ulahannan BS Masatoshi Yamazaki MD Jos Jalife MD Omer Berenfeld PhD 《Heart rhythm》2007,4(7):916-924
BACKGROUND: Despite the availability of several mapping technologies for investigating the electrophysiologic mechanisms of atrial fibrillation (AF), an experimental tool enabling high-resolution mapping of electrical impulses on the endocardial surface of the intact left atrium is lacking. OBJECTIVE: The purpose of this report is to present a new optical mapping approach implementing a steerable cardio-endoscope in isolated hearts. METHODS: The system consists of a direct or side-view endoscope coupled to a 532-nm excitation laser for illumination and a CCD camera for imaging of potentiometric dye fluorescence (di-4-ANEPPS, 80 x 80 pixels, 200-800 frames/s). The cardio-endoscope was aimed successively at diverse posterior left atrial locations to obtain high-resolution movies of electrical wave propagation and detailed endocardial anatomic features in the presence and absence of atrial stretch. RESULTS: We present several examples of high-resolution endoscopic posterior left atrial recordings of wave propagation patterns during both sinus rhythm and AF with signal-to-noise ratio similar to conventional optical mapping systems. We demonstrate the endoscope's ability to visualize highly organized AF sources (rotors) at specific locations on the posterior left atrium and posterior left atrium-pulmonary vein junctions. We present video images of waves emanating from such sources as they propagate into pectinate muscles in the left atrial appendage. In particular, we demonstrate this approach is ideally suited for studying the effects of atrial stretch on AF dynamics. CONCLUSION: In isolated hearts, cardio-endoscopic optical mapping of electrical activity should enable comprehensive evaluation of AF activity in the posterior left atrium, the role of local anatomy on AF dynamics, and the efficacy of pharmacologic and ablative interventions. 相似文献
74.
Dondorp AM Fanello CI Hendriksen IC Gomes E Seni A Chhaganlal KD Bojang K Olaosebikan R Anunobi N Maitland K Kivaya E Agbenyega T Nguah SB Evans J Gesase S Kahabuka C Mtove G Nadjm B Deen J Mwanga-Amumpaire J Nansumba M Karema C Umulisa N Uwimana A Mokuolu OA Adedoyin OT Johnson WB Tshefu AK Onyamboko MA Sakulthaew T Ngum WP Silamut K Stepniewska K Woodrow CJ Bethell D Wills B Oneko M Peto TE von Seidlein L Day NP White NJ;AQUAMAT group 《Lancet》2010,376(9753):1647-1657
75.
Grill J Puget S De Carli E Amoroso L Taylor M Brauner R Leblond P Kieffer V Laurent-Vannier A Dufour C Bourgeois M Wicart P Dhermain F Oppenheim D Sainte-Rose C Kalifa C 《Neuro-Chirurgie》2008,54(5):623-641
This chapter presents guidelines for the follow-up of children with brain tumors, whether benign or malignant, in their transition to adulthood. The consequences of their disease and its treatment overlap greatly. The complications and long-term follow-up are detailed based on the specialists involved. 相似文献
76.
Imoukhuede EB Andrews L Milligan P Berthoud T Bojang K Nwakanma D Ismaili J Buckee C Njie F Keita S Sowe M Lang T Gilbert SC Greenwood BM Hill AV 《The American journal of tropical medicine and hygiene》2007,76(3):486-493
The feasibility of using a sensitive polymerase chain reaction (PCR) to evaluate malaria vaccines in small group sizes was tested in 102 adult Gambian volunteers who received either the malaria vaccine regimen FP9 ME-TRAP/MVA ME-TRAP or rabies vaccine. All volunteers received the antimalarial drugs primaquine and Lapdap plus artesunate to eliminate malaria parasites. Volunteers in a further group received an additional single treatment with sulfadoxine-pyrimethamine (SP) to prevent new infections. There was substantially lower T-cell immunogenicity than in previous trials with this vaccine regimen and no protection against infection in the malaria vaccine group. Using the primary endpoint of 20 parasites per mL, no difference was found in the prevalence of low-level infections in volunteers who received SP compared with those who did not, indicating that SP did not reduce the incidence of very low-density infection. However, SP markedly reduced the incidence of higher density infections. These findings support the feasibility and potential of this approach to screen pre-erythrocytic vaccines for efficacy against infection in small numbers of vaccinees in endemic areas. 相似文献
77.
Bojang KA 《Expert review of vaccines》2006,5(5):611-615
Malaria prevention and treatment is becoming increasingly difficult as drug-resistant strains of parasites spread globally and affordable antimalarial drugs become ineffective. Therefore, there is a need for a safe and effective vaccine. In recent years, significant technological advances and an increase in funding for malaria vaccine research, including better public-private collaboration, have increased optimism that highly effective vaccines can be developed. RTS,S/AS02A is a novel pre-erythrocytic vaccine based on the Plasmodium falciparum circumsporozoite surface protein. Among all candidate vaccines developed thus far, only the RTS,S/AS02A vaccine has consistently been demonstrated to be well tolerated and provide significant protective efficacy in challenge studies and clinical trials in malaria-endemic countries. 相似文献
78.
79.
80.
Disparities in breast cancer 总被引:4,自引:0,他引:4