全文获取类型
收费全文 | 329篇 |
免费 | 6篇 |
专业分类
儿科学 | 100篇 |
妇产科学 | 1篇 |
基础医学 | 15篇 |
临床医学 | 8篇 |
内科学 | 62篇 |
皮肤病学 | 2篇 |
神经病学 | 13篇 |
特种医学 | 49篇 |
外科学 | 10篇 |
预防医学 | 10篇 |
眼科学 | 1篇 |
药学 | 2篇 |
肿瘤学 | 62篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 6篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 7篇 |
2014年 | 3篇 |
2013年 | 4篇 |
2012年 | 11篇 |
2011年 | 6篇 |
2010年 | 3篇 |
2009年 | 9篇 |
2008年 | 4篇 |
2007年 | 16篇 |
2006年 | 17篇 |
2005年 | 23篇 |
2004年 | 8篇 |
2003年 | 19篇 |
2002年 | 11篇 |
2001年 | 16篇 |
2000年 | 15篇 |
1999年 | 16篇 |
1998年 | 6篇 |
1997年 | 5篇 |
1996年 | 8篇 |
1995年 | 4篇 |
1994年 | 6篇 |
1993年 | 7篇 |
1992年 | 15篇 |
1991年 | 9篇 |
1990年 | 10篇 |
1989年 | 9篇 |
1988年 | 10篇 |
1987年 | 10篇 |
1986年 | 10篇 |
1985年 | 2篇 |
1984年 | 5篇 |
1982年 | 1篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1974年 | 4篇 |
1972年 | 1篇 |
排序方式: 共有335条查询结果,搜索用时 375 毫秒
51.
Mamadou Saliou Kalifa Diallo Muriel Rabilloud Ahidjo Ayouba Abdoulaye Touré Guillaume Thaurignac Alpha Kabinet Keita Christelle Butel Cécé Kpamou Thierno Alimou Barry Mariama Djouldé Sall Ibrahima Camara Sandrine Leroy Philippe Msellati René Ecochard Martine Peeters Mamadou Saliou Sow Eric Delaporte Jean-François Etard 《The Lancet infectious diseases》2019,19(3):308-316
52.
Negretti L Bouchireb K Levy-Piedbois C Habrand JL Dhermain F Kalifa C Grill J Dufour C 《Journal of neuro-oncology》2011,104(3):773-777
We report herein our institutional experience in the treatment of diffuse intrinsic pontine glioma (DIPG) with a hypofractionated
external-beam radiotherapy schedule. Between April 1996 and January 2004, 22 patients (age 2.9–12.5 years) with newly diagnosed
DIPG were treated by hypofractionated radiation therapy delivering a total dose of 45 Gy in daily fractions of 3 Gy, given
over 3 weeks. No other treatment was applied concomitantly. Fourteen of the 22 patients received the prescribed dose of 45 Gy
in 15 fractions of 3 Gy, and 2 patients received a total dose of 60 and 45 Gy with a combination of two different beams (photons
and neutrons). In five cases the daily fraction was modified to 2 Gy due to intolerance, and one patient died due to serious
intracranial hypertension after two fractions of 3 Gy and one of 2 Gy. Among 22 children, 14 patients showed clinical improvement,
usually starting in the second week of treatment. No grade 3 or 4 acute toxicity from radiotherapy was observed. No treatment
interruption was needed. In six patients, steroids could be discontinued within 1 month after the end of radiotherapy. Median
time to progression and median overall survival were 5.7 months and 7.6 months, respectively. External radiotherapy with a
radical hypofractionated regimen is feasible and well tolerated in children with newly diagnosed DIPG. However, this regimen
does not seem to change overall survival in this setting. It could represent a short-duration alternative to more protracted
regimens. 相似文献
53.
54.
Stephanie Puget MD Nathalie Boddaert MD PhD Delphine Viguier MD Virginie Kieffer PA Christine Bulteau MD Matthew Garnett MD Delphine Callu PhD Christian Sainte‐Rose MD Chantal Kalifa MD Georges Dellatolas MD PhD Jacques Grill MD PhD 《Cancer》2009,115(6):1338-1347
BACKGROUND:
Children treated for a malignant posterior fossa tumor (PFT) are at risk of intellectual impairment. Its severity is not explained by age and radiotherapy alone. The current study was designed to define the correlations between the anatomical damage and the neurological/neuropsychological deficits in children with a malignant PFT.METHODS:
Sixty‐one consecutive children (mean age, 6.0 years) treated for a malignant PFT with surgery, chemotherapy, and radiotherapy underwent a detailed neuropsychological evaluation, including a full‐scale intelligence quotient (FSIQ), on average 5.6 years after the diagnosis. The neurological examination was recorded 1 month after surgery and at the time of the neuropsychological evaluation. Cerebellar and brain injuries were scored based on the magnetic resonance imaging (MRI). Correlation of these injuries with neurological and cognitive outcome were performed after adjustment for other potential risk factors (radiotherapy schedule, age, hydrocephalus, duration of symptoms, socioeconomic status, and surgical complications).RESULTS:
Neurological deficits were strong predictors of low cognitive performances irrespective of the other risk factors. The extent of cerebellar deficits and fine motor dexterity impairment were correlated with the degree of damage to the dentate nuclei and inferior vermis. The IQ scores were inversely correlated with the severity of the damage to the dentate nuclei; mean FSIQ was 83 if they were both intact and 65 in the case of bilateral damage (P = .009).CONCLUSIONS:
Damage to the dentate nuclei and to the inferior vermis, observed on MRI, predict the degree of impairment of neurological and neuropsychological functions in children treated for a malignant PFT. Cancer 2009. © 2009 American Cancer Society. 相似文献55.
56.
P Chastagner O Hartmann C Tancrede C Kalifa C Patte F Flamant J Lemerle 《Bone marrow transplantation》1989,4(4):393-398
In order to determine the effect of parenteral antibiotherapy on the fecal flora in patients with profound and prolonged granulocytopenia, we initiated a prospective study of 62 cases of autologous bone marrow transplantation following high-dose chemotherapy. All patients were children from 2 to 18 years old, isolated in a protective environment, receiving a diet low in viable microbial content but no oral non-absorbable prophylactic antibiotics to decontaminate the gastrointestinal tract. Bacteriological analysis of fecal flora was conducted at least once a week before and during parenteral antibiotherapy, administered at the first greater than 38 degrees C febrile episode in these granulocytopenic patients (granulocyte count less than 0.5 X 10(9)/l). The 58 evaluable patients fell into three groups with regard to the systemic antibiotherapy: group A (n = 16): moxalactam + mezlocillin; group B (n = 15): moxalactam + tobramycin; and group C (n = 27): cefotaxime plus gentamicin. Fecal flora suppression was observed in 51/58 cases (88%) (group A: 15/16, group B: 13/15, group C: 23/27). It always occurred within 5 days of initiating parenteral antibiotherapy and persisted in 88% of the 51 patients over the whole period of systemic antibiotherapy. During the latter, fecal recolonization was observed in seven cases (12%), always by Enterobacteriaceae sensitive to the prescribed systemic antibiotherapy, never responsible for septicemia. Since parenteral antibiotherapy alone was able to suppress the gastrointestinal tract flora, the effects of this treatment should be considered in all trials of digestive tract decontamination. 相似文献
57.
58.
The analysis of neuropsychological sequelae in children with brain tumors is a major concern in the debate for the definition of the therapeutic strategies. The authors review the recent literature in this field in the light of their own experience at the Gustave-Roussy Institute. Three main risk factors emerge from the analysis: radiation, age and surgical complications. The need for a longitudinal evaluation in these patients is emphasized in order to plan the subsequent appropriate readaptation. 相似文献
59.
60.
B. Suarez G. Kalifa C. Adamsbaum C. Saint-Martin F. Barbotin-Larrieu 《Pediatric radiology》1995,25(5):373-374
The sonographic features of total neutropenic colitis in a 14-year-old girl with osteogenic sarcoma are presented. Sonography disclosed characteristic diffuse thickening of the colonic wall with hyperechoic bowel mucosa. Serial sonograms were performed to monitor the progress of the disease. 相似文献