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91.
Kai Dong Mengjun Shen Guanqun Ju Sha Han Zhijun Wang Kaining Lu Dongliang Xu 《European urology》2021,79(2):283-289
BackgroundPartial nephrectomy or angioembolisation is commonly used for sporadic renal angiomyolipomas (RAMLs) with high RENAL scores, but there is a risk of reduced renal function, postoperative complications, and recurrence.ObjectiveTo describe a new technique for off-clamp laparoscopic evacuation of sporadic RAMLs with high RENAL scores that promotes maximal renal function maintenance and low postoperative complication and lesion recurrence rates.Design, setting, and participantsA retrospective cohort of patients undergoing off-clamp laparoscopic evacuation for sporadic RAMLs with RENAL scores ≥9 from January 2013 to June 2018 was included.Surgical procedureWe highlighted the curettage, suction, packing, and binding (CSPB) technique, a new off-clamp retroperitoneoscopic evacuation technique for sporadic RAMLs.MeasurementsDemographics, preoperative, intraoperative, and postoperative outcomes were assessed.Results and limitationsA total of 141 cases were included. The median (interquartile range [IQR]) tumour size was 7 (6.2–8.2) cm. The median (IQR) RENAL score was 10 (9–11). The median (IQR) operative time was 80 (65–125) min, with a median (IQR) estimated blood loss of 130 (90–362.5) ml. Conversion to neither open surgery nor standard laparoscopy occurred. The warm ischaemia time was zero for all cases. Postoperatively, 13 minor complications (Clavien grade 1) were recorded. No blood transfusions were reported. The glomerular filtration rate did not change significantly from preoperative period to 12-mo follow-up. Recurrence did not occur at the median follow-up period of 48 (36–60) mo. The retrospective design and lack of a control group are limitations of this study.ConclusionsOff-clamp retroperitoneoscopic tumour evacuation using the CSPB technique is feasible, safe, and effective for treating complex sporadic RAMLs.Patient summaryWe report a curettage, suction, packing, and binding technique for off-clamp retroperitoneoscopic evacuation of sporadic renal angiomyolipomas that leads to complete lesion clearance, excellent renal function preservation, and minimal perioperative complications. 相似文献
92.
93.
94.
Chen Jingwen Xu Fengjun Yang Kai Chen Chen Wan Jixing Shen Chaofeng 《Bulletin of environmental contamination and toxicology》2022,109(2):393-400
Bulletin of Environmental Contamination and Toxicology - The toxicity of high-chlorinated polychlorinated biphenyls (PCBs) can be efficiently reduced through anaerobic dechlorination. However, this... 相似文献
95.
96.
直接法与统计法测试松质骨孔隙率的比较研究 总被引:3,自引:0,他引:3
目的 探讨松质骨孔隙率的测试方法。方法 对15根猪胫骨分别采用“直接法”与“统计法”测试松质骨孔隙率或其表观密度和材料密度。结果 (1)孔隙率与表观密度呈非常显著负相关,而与材料密度相关不显著;(2)孔隙率沿轴向靠近密质量骨逐渐减小,而沿横向基本不变;(3)统计法可测出松质骨各个层面的孔隙率大小。结论 直接法和统计法均能检测松质骨孔隙率,但统计法较直接法更能反映孔隙率的分布与变化规律。 相似文献
97.
Bisheriges Wissen zum Thema. Eine generell erh?hte psychosoziale Belastung der Eltern h?rbehinderter Kinder ist aus der Literatur bekannt. 相似文献
98.
Xin Sun Yunfeng Guo Shengdu Yang Kai Wang Lan Xie Bai Xue 《Macromolecular chemistry and physics.》2023,224(15):2300072
The poly(l -lactic acid) (PLLA)/carbon nanomaterials composite foams with hierarchical surface microstructural and internal conductive pathways are successfully prepared by a simple crystallization-assisted rapid phase separation (CARPS). The dimension and morphology of carbon nanomaterials can induce different crystallization forms to construct the hierarchical surface microstructure, and they are distributed on the phase interface of solvent and non-solvent to form conductive pathways. It is found that the heterogeneous nucleation of nanomaterials promotes a significant increase in crystallinity, and a stacked granular structure formed on the surface promotes the increase of the water contact angle to 148.7°. Foams with interconnecting pore structures contribute to the formation of 85.3% porosity and 12.33 g g−1 oil absorption. Carbon nanomaterials are distributed on the pore walls of the porous foam, which converts the foam from an insulating material to a conducting polymer. Furthermore, the uniform distribution of nanomaterials significantly affects the thermal stability of the PLLA. In belief, the multifunctional biodegradable foam, prepared by a CARPS method, makes it promising for industrial production and has potential applications in electrical conductivity, oil-water separation, and many other fields. 相似文献
99.
Kazuharu Arakawa Tetsuro Hirose Toshifumi Inada Takuhiro Ito Toshie Kai Masaaki Oyama Yukihide Tomari Takao Yoda Shinichi Nakagawa 《Genes to cells : devoted to molecular & cellular mechanisms》2023,28(8):539-552
A long-standing assumption in molecular biology posits that the conservation of protein and nucleic acid sequences emphasizes the functional significance of biomolecules. These conserved sequences fold into distinct secondary and tertiary structures, enable highly specific molecular interactions, and regulate complex yet organized molecular processes within living cells. However, recent evidence suggests that biomolecules can also function through primary sequence regions that lack conservation across species or gene families. These regions typically do not form rigid structures, and their inherent flexibility is critical for their functional roles. This review examines the emerging roles and molecular mechanisms of “nondomain biomolecules,” whose functions are not easily predicted due to the absence of conserved functional domains. We propose the hypothesis that both domain- and nondomain-type molecules work together to enable flexible and efficient molecular processes within the highly crowded intracellular environment. 相似文献
100.
D. Richter A. Bosse A. Weber K.-M. Müller G. Muhr 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1995,380(6):354-358
Zusammenfassung Es wird uber ein epitheloid-differenziertes Osteosarkom des distalen Oberschenkels mit nur minimaler Osteoidbildung and positiver Immunreaktion mit Antikörpern gegen das mesenchymale Zytoskelettprotein Vimentin bei einer 23jährigen Patientin berichtet. Metastasenverddchtige Areale fanden sich in der 5. Rippe sowie oberhalb des rechten Nierenpols. Bei fehlendem Ansprechen auf eine adjuvante Chemotherapie mußte aufgrund eines Lokalrezidivs 1 Jahr nach Tumorprothesenimplantation eine Oberschenkelamputation vorgenommen werden. Die Patientin verstarb 2,5 Jahre nach der Erstdiagnosestellung. Die Literaturberichte uber das seltener epitheloide Osteosarkom zeigen die Schwierigkeiten der differentialdiagnostischen Abgrenzung von der Metastase eines epithelialen Tumors.
Epitheloid osteosarcoma — problems with diagnosis
The case of a 23-year-old female patient suffering from a rare variety of osteosarcoma of the distal femur with epithelial differentiation and only traces of osteoid is reported. The tumour cells reacted strongly to antibodies against vimentin. Metastases were found in the fifth rib and the right kidney. There was no response to chemotherapy. One year after implantation of a tumour prothesis of the knee a thigh amputation was necessary because of a local failure. The patient died 2.5 years after the tumour had initially been diagnosed. Other reports of this rare type of epitheloid osteosarcoma illustrate the difficulties involved in reaching a correct diagnosis. This tumour can be mistaken for a skeletal metastasis of an epithelial tumour.相似文献