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101.
Feng Xie Shu-Chuen Li Ron Goeree Jean-Eric Tarride Daria O’Reilly Ngai-Nung Lo Seng-Jin Yeo Kuang-Ying Yang Julian Thumboo 《Quality of life research》2008,17(4):595-601
Objective Our aim was to cross-culturally validate Chinese Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in
patients with knee osteoarthritis (OA) scheduled for total knee replacement in Singapore.
Methods Chinese WOMAC was translated from the original English version following standard guidelines. Patients were asked to complete
a questionnaire containing the WOMAC (twice within 6 days), the Short Form 36 (SF-36), and the EuroQoL EQ-5D. Reliability
was assessed using Cronbach’s alpha and intraclass correlation coefficients (ICC), dimensionality using item-to-domain correlations
and factor analyses. Convergent and discriminant construct validity was assessed using six each a priori hypotheses.
Results Chinese WOMAC was well accepted by the patients in the pilot test. The Chinese and English versions were therefore administered
to a consecutive sample of 131 Chinese- and 127 English-speaking subjects, respectively, with knee OA. Cronbach’s alpha exceeded
0.7 for all domains except for Chinese pain domain, whereas the ICC exceeded 0.7 for all domains. Hypothesized item-to-domain
correlations were observed for all items except for four items in Chinese physical function domain. The factor analyses yielded
seven and five factors with eigenvalues of more than 1.0 in the Chinese and English versions, respectively. A total of 10/12
a priori construct validity hypotheses were satisfied for the Chinese version. Weak correlations between WOMAC pain and SF-36
bodily pain and moderate correlation between WOMAC pain and EQ-5D anxiety/depression were observed.
Conclusions Chinese WOMAC was well accepted and demonstrated acceptable psychometric properties in Singaporean patients with severe knee
OA. 相似文献
102.
Sainikitha Prattipati Francis M. Sakita Tumsifu G. Tarimo Godfrey L. Kweka Jerome J. Mlangi Amedeus V. Maro Lauren A. Coaxum Sophie W. Galson Alexander T. Limkakeng Anzibert Rugakingira Sarah J. Urasa Nwora L. Okeke Blandina T. Mmbaga Gerald S. Bloomfield Julian T. Hertz 《Global Heart》2022,17(1)
Introduction:HIV confers increased risk of myocardial infarction (MI), but there has been little study of ischemic electrocardiogram (ECG) findings among people with HIV in sub-Saharan Africa.Objectives:To compare the prevalence of ischemic ECG findings among Tanzanians with and without HIV and to identify correlates of ischemic ECG changes among Tanzanians with HIV.Methods:Consecutive adults presenting for routine HIV care at a Tanzanian clinic were enrolled. Age- and sex-matched HIV-uninfected controls were enrolled from a nearby general clinic. All participants completed a standardized health questionnaire and underwent 12-lead resting ECG testing, which was adjudicated by independent physicians. Prior MI was defined as pathologic Q-waves in contiguous leads, and myocardial ischemia was defined as ST-segment depression or T-wave inversion in contiguous leads. Pearson’s chi-squared test was used to compare the prevalence of ECG findings among those with and without HIV and multivariate logistic regression was performed to identify correlates of prior MI among all participants.Results:Of 497 participants with HIV and 497 without HIV, 272 (27.8%) were males and mean (sd) age was 45.2(12.0) years. ECG findings suggestive of prior MI (11.1% vs 2.4%, OR 4.97, 95% CI: 2.71–9.89, p < 0.001), and myocardial ischemia (18.7% vs 12.1% OR 1.67, 95% CI: 1.18–2.39, p = 0.004) were significantly more common among participants with HIV. On multivariate analysis, ECG findings suggestive of prior MI among all participants were associated with HIV infection (OR 4.73, 95% CI: 2.51–9.63, p = 0.030) and self-reported family history of MI or stroke (OR 1.96, 95% CI: 1.08–3.46, p = 0.023).Conclusions:There may be a large burden of ischemic heart disease among adults with HIV in Tanzania, and ECG findings suggestive of coronary artery disease are significantly more common among Tanzanians with HIV than those without HIV. 相似文献
103.
Dominik N?rz Susanne Pfefferle Thomas Brehm Gefion Franke Ilka Grewe Birte Knobling Martin Aepfelbacher Samuel Huber Eva M. Klupp Sabine Jordan Marylyn M. Addo Julian Schulze zur Wiesch Stefan Schmiedel Marc Lütgehetmann Johannes K. Knobloch 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2022,27(26)
104.
105.
Shalaila S. Haas Linda A. Antonucci Julian Wenzel Anne Ruef Bruno Biagianti Marco Paolini Boris-Stephan Rauchmann Johanna Weiske Joseph Kambeitz Stefan Borgwardt Paolo Brambilla Eva Meisenzahl Raimo K. R. Salokangas Rachel Upthegrove Stephen J. Wood Nikolaos Koutsouleris Lana Kambeitz-Ilankovic 《Neuropsychopharmacology》2021,46(4):828
Two decades of studies suggest that computerized cognitive training (CCT) has an effect on cognitive improvement and the restoration of brain activity. Nevertheless, individual response to CCT remains heterogenous, and the predictive potential of neuroimaging in gauging response to CCT remains unknown. We employed multivariate pattern analysis (MVPA) on whole-brain resting-state functional connectivity (rsFC) to (neuro)monitor clinical outcome defined as psychosis-likeness change after 10-hours of CCT in recent onset psychosis (ROP) patients. Additionally, we investigated if sensory processing (SP) change during CCT is associated with individual psychosis-likeness change and cognitive gains after CCT. 26 ROP patients were divided into maintainers and improvers based on their SP change during CCT. A support vector machine (SVM) classifier separating 56 healthy controls (HC) from 35 ROP patients using rsFC (balanced accuracy of 65.5%, P < 0.01) was built in an independent sample to create a naturalistic model representing the HC-ROP hyperplane. This model was out-of-sample cross-validated in the ROP patients from the CCT trial to assess associations between rsFC pattern change, cognitive gains and SP during CCT. Patients with intact SP threshold at baseline showed improved attention despite psychosis status on the SVM hyperplane at follow-up (p < 0.05). Contrarily, the attentional gains occurred in the ROP patients who showed impaired SP at baseline only if rsfMRI diagnosis status shifted to the healthy-like side of the SVM continuum. Our results reveal the utility of MVPA for elucidating treatment response neuromarkers based on rsFC-SP change and pave the road to more personalized interventions.Subject terms: Predictive markers, Psychosis 相似文献
106.
Georg Hahn Sharon M. Lutz Julian Hecker Dmitry Prokopenko Michael H. Cho Edwin K. Silverman Scott T. Weiss Christoph Lange 《Genetic epidemiology》2021,45(1):82-98
locStra is an ‐package for the analysis of regional and global population stratification in whole‐genome sequencing (WGS) studies, where regional stratification refers to the substructure defined by the loci in a particular region on the genome. Population substructure can be assessed based on the genetic covariance matrix, the genomic relationship matrix, and the unweighted/weighted genetic Jaccard similarity matrix. Using a sliding window approach, the regional similarity matrices are compared with the global ones, based on user‐defined window sizes and metrics, for example, the correlation between regional and global eigenvectors. An algorithm for the specification of the window size is provided. As the implementation fully exploits sparse matrix algebra and is written in C++, the analysis is highly efficient. Even on single cores, for realistic study sizes (several thousand subjects, several million rare variants per subject), the runtime for the genome‐wide computation of all regional similarity matrices does typically not exceed one hour, enabling an unprecedented investigation of regional stratification across the entire genome. The package is applied to three WGS studies, illustrating the varying patterns of regional substructure across the genome and its beneficial effects on association testing. 相似文献
107.
108.
Julian Brunner Cindy L. Cain Elizabeth M. Yano Alison B. Hamilton 《Women's health issues》2019,29(1):64-71
Background
The Veterans Health Administration (VHA) faces challenges in providing comprehensive, gender-sensitive care for women. National policies have led to important advancements, but local leadership also plays a vital role in implementing changes and operationalizing national priorities. In this article, we explore the notions of ideal women veterans' health care articulated by women's health leaders at local VHA facilities and regional networks, with the goal of identifying elements that could inform practice and policy.Methods
We conducted semistructured interviews with 86 local and regional women's health leaders at 12 VHA medical centers across four regions. At the conclusion of interviews about women's primary care, participants were asked to imagine “ideal care” for women veterans. Interviews were transcribed and coded using a hybrid inductive/deductive approach.Results
In describing ideal care, participants commonly touched on whether women veterans should have separate primary care services from men; the need for childcare, expanded reproductive health services, resources, and staffing; geographic accessibility; the value of input from women veterans; the physical appearance of facilities; fostering active interest in women's health across providers and staff; and the relative priority of women's health at the VHA.Conclusions
Policy and practice changes to care for women veterans must be mindful of key stakeholders' vision for that care. Specific features of that vision include clinic construction that anticipates a growing patient population, providing childcare and expanded reproductive health services, ensuring adequate support staff, expanding mechanisms to incorporate women veterans' input, and fostering a culture oriented towards women's health at the organizational level. 相似文献109.
Nelly J. Yatich Pauline E. Jolly Ellen Funkhouser Tsiri Agbenyega Julian C. Rayner John E. Ehiri Archer Turpin Jonathan K. Stiles William O. Ellis Yi Jiang Jonathan H. Williams 《The American journal of tropical medicine and hygiene》2010,82(1):28-34
This study was conducted to investigate the effect of Plasmodium falciparum and intestinal helminth coinfection on maternal anemia and birth outcomes. A cross-sectional study of 746 women who delivered in two hospitals in Kumasi was conducted. Data were collected using an investigator-administered questionnaire and from patients'' medical records. Blood was collected for determination of P. falciparum and hemoglobin levels. Adverse pregnancy outcomes were high (44.6%). Coinfection (versus no infection) was associated with 3-fold increase in low birth weight. For women with anemia, coinfection was 2.6 times and 3.5 times as likely to result in preterm deliveries and small for gestational age infants. The odds of having anemia was increased almost 3-fold by coinfection. Coinfection (versus helminth only) resulted in increased risks of anemia, low birth weight, and small for gestational age infants. This study demonstrates that women with malaria and intestinal helminth coinfection are at particular risk of adverse birth outcomes. 相似文献
110.
All Patients With the T(11; 16)(q23; p13.3) That Involves MLL and CBP Have Treatment-Related Hematologic Disorders 总被引:14,自引:0,他引:14