Sleep complaints and their relation with drug treatment in patients suffering from Parkinson's disease.

The aim of this research was to quantify sleep problems in patients suffering from Parkinson's disease by means of the new Parkinson's Disease Sleep Scale (PDSS) and to correlate such problems with the possible influence of current drug treatment. A total of 70 patients (36 men and 34 women) with a diagnosis of Parkinson's disease were enrolled. Their mean age was 69.7 +/- 8.2 years, and duration of disease was 7.4 +/- 4.8 years. All patients completed the PDSS and the Unified Parkinson's Disease Rating Scale (UPDRS Parts I-IV). Drug consumption and doses were registered. The mean score on the PDSS scale was 109.23 +/- 19.75 and on the UPDRS III scale was 25.24 +/- 11.35. The lowest scores were obtained in Item 3 (sleep fragmentation): 5.53 (2.46); and in Item 8 (nocturia): 5.75 (2.91). There was a weak correlation between the PDSS and UPDRS III (cc = -0.355, P = 0.003), PDSS and UPDRS I (cc = -0.272, P = 0.02), and PDSS and UPDRS IV (cc = -0.416, P < 0.001). Motor conditions, mental state, and drug complications influence sleep quality. Although this effect was significant, it was not of a great magnitude. Dopaminergic drugs did not increase daytime sleepiness. As a whole, sleep quality in patients who took dopaminergic agonists did not differ from that of patients who took levodopa in monotherapy.     

家用增压泵在进口中药液体包装机中的应用

本文介绍一种用国产热水增压泵替代进口中药包装机加压泵的方法.     

Hyperoxaluria, nephrolithiasis, nephrocalcinosis and renal failure after massive resection of the small intestine: report of a case.

Hyperoxaluria is frequently seen in patients with inflammatory bowel disease, or after resection of the ileum. It is assumed to be responsible for the development of nephrolithiasis, nephrocalcinosis (oxalate nephrosis) and progressive renal impairment in these patients. Steatorrhea may aggravate the severity of hyperoxaluria. A 60-year-old male underwent massive resection of the jejunum and ileum 10 years prior to admission, due to strangulation of the small bowel, with occlusion of the superior mesenteric artery. He remained well except for steatorrhea which developed two-and-a-half years prior to admission, when microhematuria, proteinuria and oxaluria developed progressively. Since that time, the nephrolithiasis, nephrocalcinosis and renal failure have continued to worsen despite therapy with oxalate restriction and oxalate-binding agents. A renal biopsy, performed late in the clinical course, showed severe changes in the renal parenchyma. The decline in renal function proved irreversible. The unusual metabolic consequences of massive resection of the small intestine and their mechanisms are discussed.     

米非司酮对人子宫内膜癌HHUA细胞ER、PR及亚型体外作用的研究

目的　探讨抗孕激素米非司酮体外对人子宫内膜癌HHU A细胞ER、PR及亚型的影响及其与抗肿瘤作用的相关性。方法　体外培养子宫内膜癌HHU A细胞,不同浓度米非司酮处理细胞4 8小时,采用逆转录-聚合酶链反应(RT- PCR)半定量法检测PR- A m RNA,PR- B m RNA的表达水平;应用免疫组化法检测HHU A细胞ER、PR受体蛋白的表达变化。结果　米非司酮(5 μmol/ L)显著地降低HHU A细胞PR- B m RNA和PR受体蛋白的表达水平(P<0 .0 5 ) ,但增加米非司酮剂量并不能增强其降调作用。抗孕激素米非司酮对HHU A细胞PR- Am RNA和ER受体蛋白表达无明显影响(P>0 .0 5 )。结论　抗孕激素米非司酮可明显降调子宫内膜癌HHU A细胞PR- B m RNA水平和PR蛋白的表达,并与抑制癌细胞增殖密切相关     

核骨架/核基质结合区及其功能研究的进展

长期以来的研究只能用结合试验来证明核基质结合区(MARs)的存在,对其真正的功能了解甚少.直到最近,人们才发现了MARs的一些生物学活性,MARs参与襻环的形成和染色体的高级包装,在真核生物的转录调控和凋亡方面起到了重要作用.对MARs的生物学功能仍在进一步的研究中,本文主要就MARs的结构、在转录调控中的作用及其它一些研究进展作一综述.     

应用QQC活动提高儿科静脉穿刺成功率

目的提高静脉穿刺成功率，减少患儿因反复穿刺造成的痛苦及恐惧，减轻家长因担心穿刺困难而产生的焦虑，提高治疗和抢救的效率。方法详细介绍了QQC活动在提高儿科静脉穿刺成功率的应用，包括找出目前存在的问题，确定目标、采用流程图的方法分析问题存在的原因，制定相应的质量改进方案，并测量实施结果。结果实施QQC活动后静脉穿刺成功率比实施前明显提高。结论有效的QQC活动可以提高静脉穿刺成功率。     

丙帕锗的制备及分析

目的 探索合成条件，制备体内活性和稳定性好的高聚物丙帕锗．并分析其结构确定目的物的正确性。方法 以GeO2为起始原料，磷酸二氢钠为还原剂,制备3-氧锗丙烯酸低分子量聚合物和高分子量3-氧锗丙烯酸(丙帕锗)，并进行元素、红外光谱、核磁共振和X-射线的分析。结果 高分子量聚合物生成，在320℃以下不分解，终产率为72．9％。结论 所采用的方法可行，合成的产品结构正确。     

截瘫患者医院感染的监测及预防措施

目的了解截瘫患者医院感染的病原菌对药物敏感情况. 方法回顾分析我院自1996年9月～2003年11月,316例截瘫患者的有关临床资料. 结果 98例患者发生医院感染,医院感染率为31.01%,感染部位主要以呼吸道、皮肤软组织、手术切口、泌尿道感染为多;医院感染的病原菌主要是条件致病菌,以G-菌为主.结论医护人员必须严格无菌操作,根据细菌药敏结果合理选用抗菌药物,加强营养,提高患者机体抵抗力.     

早搏联律间期缩短对血流动力学的影响

目的研究房性、室性早搏联律间期缩短与桡动脉图的关系,探讨早搏对血流动力学的影响。方法经心电图诊断为房性早搏48例及室性早搏51例,再应用心功能仪检查,通过信号处理技术对早搏桡动脉图形进行面积积分。结果①早搏桡动脉图积分面积提前率〉40%时最小,20%-40%时居中,〈20%时最大（P〈0.05）。②提前率相同情况下,左房与右房的早搏桡动脉图积分面积比较差异无统计学意义（P〉0.05）;左室与右室的早搏桡动脉图积分面积比较差异有统计学意义（P〈0.05）。③早搏时的桡动脉图积分面积最小,早搏前第一个窦性心搏居中,早搏后第一个窦性心搏最大（P〈0.05）。结论早搏对血流动力学的影响主要与早搏的联律间期长短有关,室性早搏还与其发生部位有关,早搏的代偿间歇,不能改善对血流动力学的影响。