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Cibele Almeida Santos Renata Calhes Franco de Moura Roberta Delasta Lazzari Arislander Jonathan Lopes Dumont Luiz Alfredo Ferreira Braun Claudia Santos Oliveira 《Journal of Physical Therapy Science》2015,27(5):1617-1620
[Purpose] The aim of the present study was to perform a systematic review of the
literature on the scales and methods most often used for the evaluation of upper limb
function in individuals with cerebral palsy. [Materials and Methods] Searches were
conducted in the Medline, PEDro, Lilacs, Scielo, and PubMed databases. The following
inclusion criteria were used for the selection of articles: randomized controlled study,
evaluation of upper limb function in individuals with cerebral palsy, and publication
between 2006 and 2014. The methodological quality of the articles was evaluated using the
PEDro evidence scale. [Results] Five articles met the inclusion criteria and achieved 6
points or higher on the PEDro scale of methodological quality. [Conclusion] The studies
analyzed used different evaluation scales, but no consensus has been reached thus far on
which scale is the most appropriate. Thus, further studies are needed to establish an
adequate method for the evaluation of upper limb function in individuals with cerebral
palsy.Key words: Cerebral palsy, Scale function, Upper limbs 相似文献
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Marc-Antoine de La Vega Grazia Caleo Jonathan Audet Xiangguo Qiu Robert A. Kozak James I. Brooks Steven Kern Anja Wolz Armand Sprecher Jane Greig Kamalini Lokuge David K. Kargbo Brima Kargbo Antonino Di Caro Allen Grolla Darwyn Kobasa James E. Strong Giuseppe Ippolito Michel Van Herp Gary P. Kobinger 《The Journal of clinical investigation》2015,125(12):4421-4428
BACKGROUND. Ebola virus (EBOV) causes periodic outbreaks of life-threatening EBOV disease in Africa. Historically, these outbreaks have been relatively small and geographically contained; however, the magnitude of the EBOV outbreak that began in 2014 in West Africa has been unprecedented. The aim of this study was to describe the viral kinetics of EBOV during this outbreak and identify factors that contribute to outbreak progression.METHODS. From July to December 2014, one laboratory in Sierra Leone processed over 2,700 patient samples for EBOV detection by quantitative PCR (qPCR). Viremia was measured following patient admission. Age, sex, and approximate time of symptom onset were also recorded for each patient. The data was analyzed using various mathematical models to find trends of potential interest.RESULTS. The analysis revealed a significant difference (P = 2.7 × 10–77) between the initial viremia of survivors (4.02 log10 genome equivalents [GEQ]/ml) and nonsurvivors (6.18 log10 GEQ/ml). At the population level, patient viral loads were higher on average in July than in November, even when accounting for outcome and time since onset of symptoms. This decrease in viral loads temporally correlated with an increase in circulating EBOV-specific IgG antibodies among individuals who were suspected of being infected but shown to be negative for the virus by PCR.CONCLUSIONS. Our results indicate that initial viremia is associated with outcome of the individual and outbreak duration; therefore, care must be taken in planning clinical trials and interventions. Additional research in virus adaptation and the impacts of host factors on EBOV transmission and pathogenesis is needed. 相似文献
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Blythe J.S. Adamson Jonathan D. Fuchs Carrie J. Sopher Danna M. Flood R. Paul Johnson Barton F. Haynes James G. Kublin The NIAID HIV Vaccine Trials Network 《CTS Clinical and Translational Science》2015,8(2):166-168
Engagement of early stage investigators (ESIs) in the search for a safe and effective vaccine is critical to the success of this highly challenging endeavor. In the wake of disappointing results from a large‐scale efficacy trial, the HIV Vaccine Trials Network (HVTN) and Center for HIV/AIDS Vaccine Immunology (CHAVI) developed a novel mentored research program focused on the translation of findings from nonhuman primate studies to human trials of experimental vaccines. From 2008 to 2011, 14 ESI Scholars were selected from 42 complete applications. Post program surveys and tracked outcomes suggest that the combination of flexible funding, transdisciplinary mentorship, and structured training and networking promoted the scientific contributions and career development of promising ESIs. Embedding a multicomponent research program within collaborative clinical trial networks and research consortia is a promising strategy to attract and retain early career investigators and catalyze important translational science. 相似文献
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