全文获取类型
收费全文 | 904902篇 |
免费 | 63246篇 |
国内免费 | 2000篇 |
专业分类
耳鼻咽喉 | 11338篇 |
儿科学 | 28500篇 |
妇产科学 | 21652篇 |
基础医学 | 135977篇 |
口腔科学 | 24337篇 |
临床医学 | 82744篇 |
内科学 | 176342篇 |
皮肤病学 | 18787篇 |
神经病学 | 68708篇 |
特种医学 | 32320篇 |
外国民族医学 | 89篇 |
外科学 | 135640篇 |
综合类 | 18116篇 |
现状与发展 | 4篇 |
一般理论 | 447篇 |
预防医学 | 69687篇 |
眼科学 | 20445篇 |
药学 | 67664篇 |
4篇 | |
中国医学 | 2696篇 |
肿瘤学 | 54651篇 |
出版年
2021年 | 8617篇 |
2019年 | 8567篇 |
2018年 | 11590篇 |
2017年 | 9132篇 |
2016年 | 9998篇 |
2015年 | 11347篇 |
2014年 | 15948篇 |
2013年 | 23717篇 |
2012年 | 32805篇 |
2011年 | 34944篇 |
2010年 | 20388篇 |
2009年 | 18819篇 |
2008年 | 32840篇 |
2007年 | 35212篇 |
2006年 | 35069篇 |
2005年 | 34108篇 |
2004年 | 33085篇 |
2003年 | 31202篇 |
2002年 | 30275篇 |
2001年 | 38120篇 |
2000年 | 38288篇 |
1999年 | 32319篇 |
1998年 | 10578篇 |
1997年 | 8983篇 |
1996年 | 9074篇 |
1995年 | 8495篇 |
1994年 | 7774篇 |
1993年 | 7180篇 |
1992年 | 24129篇 |
1991年 | 24018篇 |
1990年 | 23317篇 |
1989年 | 22996篇 |
1988年 | 21005篇 |
1987年 | 20394篇 |
1986年 | 19409篇 |
1985年 | 18349篇 |
1984年 | 14080篇 |
1983年 | 12127篇 |
1982年 | 7662篇 |
1981年 | 6820篇 |
1979年 | 12309篇 |
1978年 | 9045篇 |
1977年 | 7731篇 |
1976年 | 7394篇 |
1975年 | 7928篇 |
1974年 | 9134篇 |
1973年 | 8700篇 |
1972年 | 8069篇 |
1971年 | 7462篇 |
1970年 | 7189篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
21.
TG Berger F Kiesewetter C Maczek N Bauer M Lueftl G Schuler M Simon Jr 《Journal of the European Academy of Dermatology and Venereology》2006,20(2):178-183
Vitiligo and psoriasis are both common skin disorders. However, psoriasis strictly confined to pre-existing vitiligo areas is rare and suggests a causal relationship. We report here on two patients with a strict anatomical colocalization of vitiligo and psoriasis. The histopathological examinations showed typical changes for both diseases together with a dense infiltrate of CD4+ and CD8+ T cells. By immunohistochemistry, intracytoplasmatic granzyme B and tumour necrosis factor alpha (TNF-alpha) were detected within the T-cell population, suggesting the functional activity of these cells and the creation of a local T helper 1 (Th1)-cytokine milieu. Additionally, in one patient we could identify anti-melanocytic T cells by tetramer staining and enzyme-linked immunospot (ELISPOT) analysis. These skin-infiltrating lymphocytes might trigger, by the local production of Th-1 cytokines such as TNF-alpha and interferon-gamma (IFN-gamma), the eruption of psoriatic plaques in patients with a genetic predisposition for psoriasis. 相似文献
22.
Eileen Dauer John Salassa Laura Iuga Jan Kasperbauer 《Otolaryngology--head and neck surgery》2006,134(5):830-835
OBJECTIVE: To illustrate the safety and efficacy of the endoscopic laser approach for cricopharyngeal myotomy (CPM) compared to the traditional transcervical approach. STUDY DESIGN AND SETTING: Retrospective chart review of 22 patients undergoing CPM from 1996 to 2003 at the Mayo Clinic, Jacksonville. RESULTS: The laser CPM technique was used in 14 patients, and an open approach in 8. The mean hospital stay and operative times were shorter for the laser group. Functional outcome analyses showed improvement in both groups. There were no major complications in the laser group, while 1 patient in the transcervical group had a pharyngocutaneous fistula. CONCLUSIONS: The laser technique is at least as effective as the transcervical approach for CPM to improve dysphagia symptoms in the properly selected patient, with a low risk of major complications. SIGNIFICANCE: In this report, we provide the reader with data to support the safety and efficacy of laser CPM. EBM rating: B-3b. 相似文献
23.
24.
25.
Baha’ N. Noureddin Christiane E. Al-Haddad Ziad Bashshur Bared Safieh-Garabedian 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2006,244(6):750-752
Background The objective was to measure the plasma concentrations of thymulin and nerve growth factor (NGF) in a group of patients with primary open angle glaucoma (POAG) and compare them with age- and sex-matched normal controls.Methods Twenty-eight patients newly diagnosed with POAG who were not undergoing treatment were compared with the same number of age- and sex-matched healthy controls. Blood samples were drawn into heparinized tubes and plasma samples were collected for the determination of the concentrations of thymulin and NGF, using specific enzyme-linked immunosorbent assay (ELISA). The Student’s t test was used to perform the necessary statistical analysis of the results.Results Seventeen women and 11 men were enrolled in each of the two groups (study and control), with a mean age of 63.7 (SD 10.3) years in the former and 63.3 (SD 9.6) years in the latter. There was a highly significant (p<0.001) elevation in the thymulin levels in POAG patients compared with the control group. However, no significant difference was observed when comparing the plasma NGF levels.Conclusion This is the first report to measure plasma thymulin levels in glaucoma patients. The significant results point the possible role of this immunomodulator in the pathogenesis of primary open angle glaucoma. The potential role of NGF seems to be less likely. These findings warrant further investigation. 相似文献
26.
27.
Carmine Nieuwstraten N Renee Labiris Anne Holbrook 《Revue canadienne de psychiatrie》2006,51(5):300-316
OBJECTIVE: Antidepressants are commonly used drugs with potential for numerous drug interactions. This study aims to systematically review the literature on drug interactions with antidepressants. METHODS: We searched MEDLINE (1966 to November 2003) and EMBASE (1980 to 2003), using the heading drug interactions combined with individual antidepressant names. We restricted searches to English-language articles and human studies. We screened drug interaction texts and review articles for relevant studies. We included articles reporting original human data on drug interactions with antidepressants commonly used in North America. Articles were independently evaluated by 2 reviewers on clinical effect, clinical significance, and quality of evidence. Discrepancies were resolved by consensus. RESULTS: There were 904 eligible interactions, involving 9509 patients, for a total of 598 summary interactions. Of these, 439 (73%) demonstrated an interaction, 148 (25%) had no effect, and 11 (2%) had conflicting evidence. For 510 interactions (85%), the quality of evidence was poor. It was fair for 67 (11%) interactions and good for 10 (2%) interactions. There were no interactions with excellent quality of evidence. There were 145 (24%) interactions of major clinical significance. These were predominantly hypertensive emergencies and serotonin syndrome. Most interacting drugs had central nervous system (CNS) activity. As expected, monoamine oxidase inhibitors (MAOIs) appear to be the most problematic family in terms of potential for serious drug interactions. CONCLUSIONS: Drug interactions with antidepressants are an important cause for concern, but this concern is based primarily on poor evidence. We recommend caution when combining antidepressants with other CNS drugs, particularly when coadministering MAOIs with other substances. 相似文献
28.
N Simelela 《International journal of gynaecology and obstetrics》2006,94(3):292-300
Preventing unintended pregnancies through access to modern family planning could avert 20-35% of maternal deaths, saving the lives of more than 100,000 women each year. Obstacles to wider access still exist, but they may be overcome by overt policy commitment to reproductive health services, partnership between stakeholders, community involvement and quality programs. 相似文献
29.
30.