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111.
Yuxin Huang Yuanyuan Xu Jieyuzhen Qiu Cuiping Jiang Wen Tan Xiaoming Tao Qin Gu Jiao Sun 《Medicine》2021,100(13)
This study was aimed at assessing the impact of the dusk phenomenon on the total glucose exposure in Chinese people with type 2 diabetes.A total of 380 type 2 diabetes who received a retrospective continuous glucose monitoring system (CGMs) for 72 hours were enrolled in our study, 32 of them failed in CGMs. The patients were first divided into 2 groups: dusk phenomenon (n = 95) and non dusk phenomenon group (n = 253). The magnitude of the dusk phenomenon (δDusk) was quantified by pre-dinner glucose minus post-lunch 2 hours glucose. A persistent δDusk ≥ 0 or a once only δDusk < 0 can be diagnosed with the dusk phenomenon. The participants were secondarily matched for the post-lunch 2 hours glucose to assess the impact of the dusk phenomenon on the overall glucose exposure. The impact of the dusk phenomenon was assessed on high-performance liquid chromatography assay (HbA1c) and 24-hour mean glucose.There were 95 of 348 (27.3%) participants with the dusk phenomenon in the overall population, and the median of δDusk level was –0.8 (–1.8, 0.2) mmol/L. The median of glucose differences between the 2 paired groups were 0.4 (–0.4, 1.0)% for HbA1c, 0.9 (0.2, 1.4) mmol/L for 24 hours mean glucose. The correlation analysis showed no relationship between the magnitude of dawn phenomenon and the dusk phenomenon (r = 0.052, P = .472).The incidence of dusk phenomenon is about 27.3% in people with type 2 diabetes. The impacts of dusk phenomenon on HbA1c and 24-hour mean glucose were about 0.4% and 0.9 mmol/L and the dusk phenomenon was not related with the dawn phenomenon. 相似文献
112.
Jie Xie Yan Yang Jiali Sun Zhi Jiao Haozheng Zhang Jie Chen 《Clinical breast cancer》2019,19(1):e195-e207
Purpose
Six-transmembrane epithelial antigen of prostate 1 (STEAP1) is a cell surface antigen overexpressed in multiple cancers and is associated with malignancy and disease prognosis. The aims of this study were to evaluate STEAP1 expression in breast cancer and to determine the mechanisms involved.Methods
STEAP1 expression was compared in normal breast tissue (n = 40), benign fibroadenoma (n = 52), and primary breast cancer (n = 211) using immunohistochemistry. Quantitative real-time polymerase chain reaction, Western blot analysis, and immunocytochemistry were used to evaluate STEAP1 expression in 3 breast cancer cell lines and in a normal mammary epithelial cell line. STEAP1 expression and its prognostic value in breast cancer were verified using the Oncomine and Kaplan-Meier Plotter databases. Transfection of cells to up-regulate or knock down STEAP1 expression was used to determine the effect of STEAP1 on cell invasion and proliferation, and to evaluate its relationship to epithelial–mesenchymal transition (EMT) progression.Results
STEAP1 expression was lower in breast cancers cells, and low expression was associated with a malignant phenotype and poor prognosis. Analysis of public databases supported our conclusions. Knockdown of STEAP1 expression enhanced cellular invasion and migration abilities, increased expression of EMT-related genes MMP2, MMP9, MMP13, VIM, and CDH2, and decreased CDH1 expression. Enhanced STEAP1 expression significantly inhibited cellular invasion and migration abilities, decreased expression of the EMT-related genes, and increased CDH1 expression. Up-regulation or knockdown of STEAP1 had little effect on cellular proliferation.Conclusion
STEAP1 was down-regulated in breast cancer, inhibited metastasis of breast cancer, and hampered the levels of EMT markers, which thus implicated STEAP1 in the suppression of EMT. 相似文献113.
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117.
Fubo Zhou Yang Hua Xunming Ji Lingyun Jia Ke Zhang Qing Li Qiuping Li Jie Yang Jingzhi Li Liqun Jiao 《Ultrasound in medicine & biology》2021,47(2):244-251
The aim of this study was to identify the ultrasound-based carotid plaque characteristics associated with new cerebral ischemic lesions after carotid endarterectomy (CEA). Between January 2013 and December 2018, carotid duplex ultrasound was performed in 1061 patients who underwent CEA. Brain magnetic resonance diffusion-weighted imaging (DWI) was performed pre-operatively and within 30 d after CEA. New cerebral ischemic lesions on DWI were observed in 169 patients. The cutoff value gray-scale median (GSM) used to distinguish DWI-positive from DWI-negative patients was 30.5, with an area under the receiver operating characteristic curve of 0.837. A larger proportion of multiple DWI lesions were observed in the GSM ≤30.5 group (59.5% vs. 41.5%, p = 0.030). Univariate and multivariate analyses identified GSM ≤30.5, ulcerated carotid plaques and pre-operative ischemic symptoms as predictors of post-operative cerebral DWI lesions. Our results indicate that ultrasound-based carotid plaque characteristics help predict new cerebral ischemic lesions after CEA. 相似文献
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119.
目的 探讨伊贝母异甾体生物碱对哮喘大鼠气道炎症、气道重塑及Wnt/β-catenin信号通路的影响。方法 本研究采用吸入卵清蛋白(OVA)致敏和激发的方法建立大鼠哮喘模型,连续给予药物7天;抽取支气管肺泡灌洗液(BALF)进行白细胞分类计数,酶联免疫吸附法(ELISA)检测BALF中白介素4(IL-4)、白介素5(IL-5)和白介素13(IL-13)的水平;取肺组织进行苏木精-伊红(HE)染色,观察药物对哮喘大鼠气道重塑的影响;采用Western blot技术考察异甾体生物碱对Wnt/β-catenin信号通路上Wnt5a、Wnt7b和β-catenin蛋白的调节作用。结果 与模型组比较,异甾体生物碱组大鼠肺泡间质炎性细胞浸润和支气管管腔狭窄均显著改善,支气管壁厚度和平滑肌厚度均明显降低;Western blot结果显示异甾体生物碱对于哮喘大鼠Wnt/β-catenin通路上的Wnt5a、Wnt7b和β-catenin蛋白表达均有显著的调节作用。结论 异甾体生物碱对于哮喘相关的病理变化-炎症和气道重塑均有一定的治疗作用,且该治疗作用与Wnt/β-catenin信号通路有关。 相似文献
120.
Yang Yi-Xing Liu Yin Li Xiao-Wei Lu Peng-Ju Wang Jiao Li Chang-Ping Gao Jing 《Journal of thrombosis and thrombolysis》2021,51(3):682-692
Journal of Thrombosis and Thrombolysis - Whether the clinical outcomes of stent thrombosis (ST) are different when stratified by time of occurrence remains unclear. The objective of this study was... 相似文献