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991.
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Jia-Ling Song Yao Yuan Hai-Bo Tan Ri-Ming Huang Hong-Xin Liu Zhi-Fang Xu 《Journal of Asian natural products research》2017,19(3):222-228
Two new coumarins, named (±)-euryacoumarin A (1) and 6-demethylobtusinin (2), and one new natural coumarin, named euryacoumarin B (3), along with two known compounds, scopoletin (4) and obtusinol (5), were isolated from the stems of Eurya chinensis. Their structures were elucidated by means of extensive spectroscopic methods and comparison with data reported in the literatures. Compound 1 exhibited significant inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 cells with IC50 value of 35.64 ± 1.73 μM, and showed marginal antibacterial activities against Bacillus subtilis and B. cereus with MIC values of 50.59 ± 2.12 and 35.42 ± 0.96 μM, respectively. 相似文献
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Ming-Cheng Luo Yong Q. Gu Frank M. You Karin R. Deal Yaqin Ma Yuqin Hu Naxin Huo Yi Wang Jirui Wang Shiyong Chen Chad M. Jorgensen Yong Zhang Patrick E. McGuire Shiran Pasternak Joshua C. Stein Doreen Ware Melissa Kramer W. Richard McCombie Shahryar F. Kianian Mihaela M. Martis Klaus F. X. Mayer Sunish K. Sehgal Wanlong Li Bikram S. Gill Michael W. Bevan Hana ?imková Jaroslav Dole?el Song Weining Gerard R. Lazo Olin D. Anderson Jan Dvorak 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(19):7940-7945
996.
Guo Nan Yin Ji‐Kan Ryu Mi‐Hye Kwon Sun Hwa Shin Hai‐Rong Jin Kang‐Moon Song Min Ji Choi Dong‐Yeon Kang Woo Jean Kim Jun‐Kyu Suh 《The journal of sexual medicine》2012,9(7):1760-1772
IntroductionA proper cavernous endothelial cell culture system would be advantageous for the study of the pathophysiologic mechanisms involved in endothelial dysfunction and erectile dysfunction (ED).AimTo establish a nonenzymatic technique, which we termed the “Matrigel‐based sprouting endothelial cell culture system,” for the isolation of mouse cavernous endothelial cells (MCECs) and an in vitro model that mimics in vivo situation for diabetes‐induced ED.MethodsFor primary MCEC culture, mouse cavernous tissue was implanted into Matrigel and sprouting cells from the tissue were subcultivated. To establish an in vitro model for diabetes‐induced ED, the primary cultured MCECs were exposed to a normal‐glucose (5 mmoL) or a high‐glucose (30 mmoL) condition for 48 hours.Main Outcome MeasuresThe purity of isolated cells was determined by fluorescence‐activated cell sorting analysis. MCECs incubated under the normal‐ or the high‐glucose condition were used for Western blot, cyclic guanosine monophosphate (cGMP) quantification, and in vitro angiogenesis assay.ResultsWe could consistently isolate high‐purity MCECs (about 97%) with the Matrigel‐based sprouting endothelial cell culture system. MCECs were subcultured up to the fifth passage and no significant changes were noted in endothelial cell morphology or purity. The phosphorylation of Akt and eNOS and the cGMP concentration were significantly lower in MCECs exposed to high glucose than in those exposed to normal glucose. MCECs exposed to the normal‐glucose condition formed well‐organized capillary‐like structures, whereas derangements in tube formation were noted in MCECs exposed to high glucose. The protein expression of transforming growth factor‐β1 (TGF‐β1) and phospho‐Smad2 was significantly increased by exposure to high glucose.ConclusionThe Matrigel‐based sprouting endothelial cell culture system is a simple, technically feasible, and reproducible technique for isolating pure cavernous endothelial cells in mice. An in vitro model for diabetic ED will be a valuable tool for evaluating the angiogenic potential of novel endogenous or synthetic modulators. Yin GN, Ryu J‐K, Kwon M‐H, Shin SH, Jin HR, Song K‐M, Choi MJ, Kang D‐Y, Kim WJ, and Suh J‐K. Matrigel‐based sprouting endothelial cell culture system from mouse corpus cavernosum is potentially useful for the study of endothelial and erectile dysfunction related to high‐glucose exposure. J Sex Med 2012;9:1777–1789. 相似文献
997.
Objective:To examine the validation and reliability of the distress thermometer(DT) recommended by National Comprehensive Cancer Network(NCCN) in Chinese cancer patients.Methods:A total of 574 Chinese cancer patients from Beijing Cancer Hospital completed the detection of DT,the Hospital Anxiety and Depression Scale(HADS) and Symptom Checklist 90(SCL-90),Receiver Operating Characteristic(ROC) curve and Area Under the Curve(AUC) were used to analyze the validation relative to HADS and SCL-90.The patients with DT≥4 and whose distress caused by emotional problems were interviewed with the MiNi International Neuro-psychiatric Interview(MINI)(Chinese Version 5.0).This version was used to analyze cancer patients’ psychological and Psychiatric symptoms during the cancer process;3.Another 106 cancer patients in rehabilitation stage and stable condition were asked to fill in DT two times,at the base time and after 7-10 days.Results:Data of ROC indicates that a DT cutoff score of 4 yielded AUC of 0.80 with a optimal sensitivity(0.80) and specificity(0.70) relative to HADS,and AUC of 0.83 with the greatest sensitivity(0.87) and specificity(0.72) against SCL-90.The DT also has acceptable test-retest reliability(r=0.800,P=0.000);According to the interview results,the most common psychiatric problems cancer patients have adjustment disorder,depression,and anxiety.Conclusion:The data suggest that DT has acceptable overall accuracy and reliability as a screening tool for testing distress severity and specific problems causing distress in Chinese cancer patients.It is worth being used in oncology clinic,the rapid screening and interview could help caregivers to identify psychological and psychiatric problems of cancer patients and provide useful information for further treatment. 相似文献
998.
Dong-Ju Kim Woo-Young Sun Dong-Hee Ryu Jin-Woo Park Hyo-Young Yun Jae-Woon Choi Young-Jin Song 《JOURNAL OF BREAST CANCER》2011,14(1):72-75
Microglandular adenosis (MGA) of the breast is a very rare and benign proliferative lesion. Most patients complain of a palpable breast mass that may arouse a clinical suspicion of breast cancer. Histopathologically, it is hard to distinguish MGA from breast cancer because of the lack of a myoepithelial layer and infiltrative proliferation. Several studies have reported a strong relationship between MGA and carcinoma arising in MGA, so the mass should be excised completely in cases of MGA determined from a core needle biopsy rather than observation. A 72-years-old woman presented with a palpable breast mass. On physical examination, a mass was palpable in the right upper outer quadrant area and somewhat fixed to the surrounding tissues and pectoralis major muscle. We could not detect any mass or dense lesion on mammography because of a grade 4 dense breast. Ultrasonographic findings revealed a low echoic lesion with indistinct margins. The result of a core needle biopsy was MGA, which was confirmed by excision. We report one case of MGA, which was believed to breast cancer clinically. 相似文献
999.
1000.
Kee Wook Jung Hwoon‐Yong Jung In Ja Yoon Do Hoon Kim Hye‐Won Park Jun‐Won Chung Kwi‐Sook Choi Kyung Jo Kim Kee Don Choi Ho June Song Gin Hyug Lee Jin‐Ho Kim 《Journal of gastroenterology and hepatology》2010,25(8):1452-1455
Background and Aim: The relationship between age and esophageal motility parameters (i.e. basal and residual pressure of the lower esophageal sphincter [LES]) remains to be established in achalasia patients, possibly because most previous studies did not distinguish between classic and vigorous achalasia patients. We investigated the relationship between age and esophageal motility parameters in both classic and vigorous achalasia patients. Methods: A retrospective review of esophageal manometry data in a single center was undertaken. Basal and residual pressure for LES was analyzed. A total of 103 achalasia patients were enrolled, comprising 84 classic and 19 vigorous types. They were subdivided into three different age groups as follows: 21–40 years old (group A), 41–60 years old (group B), and over 60 years old (group C). Results: In classic achalasia patients (M : F = 27:57, mean age = 44 ± 15 years old) the older age group showed a significantly higher basal LES pressure (49.62 ± 19.63 mmHg) than the younger age group (P < 0.0001). Moreover, the older age group also showed significantly high residual LES pressure (20.46 ± 8.61 mmHg) than the younger age group (P = 0.0006). In contrast, in vigorous achalasia patients (M : F = 12:7, mean age: 47 ± 15 years old) there were no difference between age and motility indices (all P > 0.05). Conclusion: In classic achalasia patients there appears to be a correlation between age and esophageal motility indices, especially basal and residual LES pressure. Such correlations do not appear to exist for vigorous achalasia patients. 相似文献