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171.
Simple measurement of spinal cord evoked potential: a valuable data source in the rat spinal cord injury model. 总被引:1,自引:0,他引:1
Jong-Pil Park Ki-Jeong Kim Ji Hoon Phi Chul-Kee Park Jong-Hoon Kim Hyo Jin Kang Dohun Lee Kyu Hyun Han Kyu-Chang Wang Sun Ha Paek 《Journal of clinical neuroscience》2007,14(11):1099-1105
Measurement of spinal cord evoked potentials (SCEPs) is proposed as a means of predicting locomotion outcome in the rat spinal cord injury (SCI) model. Using 55 rats, three reproducible peak waves (waves I, II and III) were observed during stimulation at the C7 level with recording at the L1 epidural space. Hemisection at the T13 level showed three wave loss patterns: wave III loss only, loss of both wave II and III, and loss of all three waves. Defining an ideal SCI model as establishment of stable monoparesis or paraparesis, all animals in the wave II-III loss group showed favorable results. Histological data and electrophysiological properties allowed reasonable assumptions of wave origin: wave I from extrapyramidal tracts, wave II from the ventral corticospinal tract, and wave III from the dorsal corticospinal tract. Complete destruction of pyramidal tracts in both dorsal and ventral fibers was essential for long-term impairment of locomotion. 相似文献
172.
173.
本实验用日本大耳白兔复制输精管结扎的长期动物模型,分为结扎25月组(VG25),同龄假手术25月组(SOG25);结扎6月组(VG6),同龄假手术6月组(SOG6)。记录各组家兔心功能,检测心肌及血清NE含量,称取心重(WH)。结果表明,左心室收缩期末压(LVSP),VG略高于SOG;左心室舒张末压(LVEDP),V625显著的低于SOG25P<0.05),VG6与5OG6比较虽无显著差异,也呈低值;±dp/dtmax,VG均明显高于SOG(P<0.01)。相关检验表明,+dp/dtmax与血清及心肌NE含量无相关性;心重与+dp/dtmax呈明显正相关,P<0.05;在25月组,LVSP与+dp/dtmax呈正相关,P<0.05。提示输精管结扎可提高心肌收缩功能。 相似文献
174.
目的:探讨肺良恶性病变中角蛋白和核仁组织区的表达意义。方法:采用免疫组化ABC法和AgNOR染色,对54例肺良恶性病变进行检测。结果:角蛋白表达在低分化腺癌最高,AgNOR表达以未分化癌最高。结论:角蛋白对判定肺癌类型有一定帮助,AgNOR颗粒数目对判定肺癌的分化程度和预后有重要意义。角蛋白和AgNOR对肺癌的类型鉴别及预后判定有重要作用。 相似文献
175.
急性胰腺炎CT、B超、手术及临床对照研究 总被引:5,自引:0,他引:5
笔者分析了24例急性胰腺炎的CT所见,并同B超、临床化验和剖腹探查结果进行了对照研究。表明:(1)急性胰腺炎的CT诊断优于B超,对胆源性胰腺炎B超对诊断有明确帮助。(2)急性胰腺炎时,CT表现与血淀粉酶浓度不一定成正比。(3)急性胰腺炎可累及门脉系统引起血管并发症。 相似文献
176.
INAUGURAL ARTICLE by a Recently Elected Academy Member:Characterization of a 34-kDa soybean binding protein for the syringolide elicitors
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Cheng Ji Carol Boyd David Slaymaker Yasushi Okinaka Yoji Takeuchi Sharon L. Midland James J. Sims Eliot Herman Noel Keen 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(6):3306-3311
Syringolides are water-soluble, low-molecular-weight elicitors that trigger defense responses in soybean cultivars carrying the Rpg4 disease-resistance gene but not in rpg4 cultivars. 125I-syringolide 1 previously was shown to bind to a soluble protein(s) in extracts from soybean leaves. A 34-kDa protein that accounted for 125I-syringolide 1 binding activity was isolated with a syringolide affinity-gel column. Partial sequences of internal peptides of the 34-kDa protein were identical to P34, a previously described soybean seed allergen. In soybean seeds, P34 is processed from a 46-kDa precursor protein and was shown to have homology with thiol proteases. P34 is a moderately abundant protein in soybean seeds and cotyledons but its level in leaves is low. cDNAs encoding 46-, 34-, and 32-kDa forms of the soybean protein were cloned into the baculovirus vector, pVL1392, and expressed in insect cells. The resulting 32- and 34-kDa proteins, but not the 46-kDa protein, exhibited ligand-specific 125I-syringolide binding activity. These results suggest that P34 may be the receptor that mediates syringolide signaling. 相似文献
177.
Powerful bactericidal activity of sparfloxacin (AT-4140) against Mycobacterium tuberculosis in mice. 总被引:9,自引:7,他引:2
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V Lalande C Truffot-Pernot A Paccaly-Moulin J Grosset B Ji 《Antimicrobial agents and chemotherapy》1993,37(3):407-413
The bactericidal activities of various monotherapies and combined regimens were compared in mice at different stages after infection with Mycobacterium tuberculosis. These therapies mimicked the initial and continuation phases of chemotherapy for human tuberculosis. As monotherapy, the bactericidal activity of sparfloxacin (SPFX) was dose related; the activity of SPFX at 100 mg/kg of body weight was comparable to that of rifampin (RMP) and was significantly greater than those of isoniazid (INH), pyrazinamide (PZA), or ofloxacin (OFLO) during both the initial and continuation phases of chemotherapy. During the initial phase, the addition of SPFX did not enhance or diminish the activities of the combinations INH-RMP-PZA or RMP-PZA; the combinations SPFX-PZA-streptomycin (SM) and SPFX-PZA-kanamycin (KANA) displayed powerful bactericidal activity. Because the area under the plasma concentration-time curve of SPFX (100 mg/kg) in mice is similar to that of SPFX (400 mg) in humans, the promising bactericidal activity displayed by SPFX in mice might be achieved in humans by administration of the drug in a clinically tolerated dosage. In addition, the combinations SPFX-PZA-SM and SPFX-PZA-KANA may be useful for the treatment of multidrug-resistant tuberculosis. 相似文献
178.
为探索喉气管狭窄松解瘢痕组织的方法,近四年来,对七例严重的喉气管狭窄病人进行开放性“T”型硅胶管置入术,术中应用CO2激光切除、松解瘢痕组织,所有病人术后8~12月成功拔管。证明CO2激光为喉气管狭窄重建术的一种有效辅助治疗手段 相似文献
179.
胃癌c-erbB-2过度表达与预后的关系 总被引:1,自引:0,他引:1
探讨c-erbB-2过度表达与胃癌预后的关系。方法:用免疫组化ABC法对103例胃癌手术标本及151个转移淋巴结进行c-erbB-2表达检测。结果:21.4%胃癌手术标本出现阳性表达.其中进展期胃癌、乳头状腺癌、高中分化胃癌及伴淋巴与肝转移的胃癌阳性率显著增高(P<0.05与<0.01);转移淋巴结表达阳性率高于胃癌原发灶(X2=3.7.P>0.05)。高中分化胃癌伴c-erbB-2过度表达者5年生存率显著低于阴性者(P<0.01)。结论:c-erbB-2过度表达可作为胃癌预后估计指标之一。 相似文献
180.
为研究心肌血管重建的机理,在15只鼠心、12只免心,用308nm的XeCl准分子激光在活体上照射左心室壁,形成边缘清楚而光滑的圆筒状心肌管道。在活体心室壁的激光管道周围,心肌细胞的损伤很轻微,无炭化焦痂层,未见碎片和凝固坏死层,只有薄层嗜伊红性变和肌浆凝聚两个断续的条形变化带。当心室壁由激光穿透时,血液从心腔进入激光管道,并与周围扩张的血管相通。实验结果提示,由于准分子激光不造成明显的热损伤,因而可能适合于心肌血管的重建。 相似文献