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991.
Georgia R. Gore‐Langton Matthew Cairns Yves Daniel Compaor Issaka Sagara Irene Kuepfer Issaka Zongo Mariken M. de Wit Amadou Barry Modibo Diarra Amadou Tapily Samba Coumare Ismail Thera Frederic Nikiema R. Serge Yerbanga Rosemonde M. Guissou Halidou Tinto Alassane Dicko Daniel Chandramohan Brian Greenwood Jean Bosco Ouedraogo 《Tropical medicine & international health : TM & IH》2020,25(6):740-750
992.
Kieran F. Docherty Li Shen Davide Castagno Mark C. Petrie William T. Abraham Michael Bhm Akshay S. Desai Kenneth Dickstein Lars V. Kber Milton Packer Jean L. Rouleau Scott D. Solomon Karl Swedberg Ali Vazir Michael R. Zile Pardeep S. Jhund John J.V. McMurray 《European journal of heart failure》2020,22(3):528-538
993.
Ovidiu Chioncel John Parissis Alexandre Mebazaa Holger Thiele Steffen Desch Johann Bauersachs Veli‐Pekka Harjola Elena‐Laura Antohi Mattia Arrigo Tuvia B. Gal Jelena Celutkiene Sean P. Collins Daniel DeBacker Vlad A. Iliescu Ewa Jankowska Tiny Jaarsma Kalliopi Keramida Mitja Lainscak Lars H Lund Alexander R. Lyon Josep Masip Marco Metra Oscar Miro Andrea Mortara Christian Mueller Wilfried Mullens Maria Nikolaou Massimo Piepoli Susana Price Giuseppe Rosano Antoine Vieillard‐Baron Jean M. Weinstein Stefan D. Anker Gerasimos Filippatos Frank Ruschitzka Andrew J.S. Coats Petar Seferovic 《European journal of heart failure》2020,22(8):1315-1341
Cardiogenic shock (CS) is a complex multifactorial clinical syndrome with extremely high mortality, developing as a continuum, and progressing from the initial insult (underlying cause) to the subsequent occurrence of organ failure and death. There is a large spectrum of CS presentations resulting from the interaction between an acute cardiac insult and a patient's underlying cardiac and overall medical condition. Phenotyping patients with CS may have clinical impact on management because classification would support initiation of appropriate therapies. CS management should consider appropriate organization of the health care services, and therapies must be given to the appropriately selected patients, in a timely manner, whilst avoiding iatrogenic harm. Although several consensus‐driven algorithms have been proposed, CS management remains challenging and substantial investments in research and development have not yielded proof of efficacy and safety for most of the therapies tested, and outcome in this condition remains poor. Future studies should consider the identification of the new pathophysiological targets, and high‐quality translational research should facilitate incorporation of more targeted interventions in clinical research protocols, aimed to improve individual patient outcomes. Designing outcome clinical trials in CS remains particularly challenging in this critical and very costly scenario in cardiology, but information from these trials is imperiously needed to better inform the guidelines and clinical practice. The goal of this review is to summarize the current knowledge concerning the definition, epidemiology, underlying causes, pathophysiology and management of CS based on important lessons from clinical trials and registries, with a focus on improving in‐hospital management. 相似文献
994.
Sung‐Hee Shin Brian Claggett Marc A. Pfeffer Hicham Skali Jiankang Liu David Aguilar Rafael Diaz Kenneth Dickstein Hertzel C. Gerstein Lars V. Kber Francesca C. Lawson Eldrin F. Lewis Aldo P. Maggioni John J.V. McMurray Jeffrey L. Probstfield Matthew C. Riddle Jean‐Claude Tardif Scott D. Solomon 《European journal of heart failure》2020,22(7):1133-1143
995.
Alessandra Mangia Tivadar Bányai Giuseppe De Bartolomeo Judit Gervain François Habersetzer Jean‐Pierre Mulkay Denis Ouzan Giustino Parruti Nicola Passariello Andre‐Jean Remy Mario Rizzetto Mitchell L. Shiffman Manuela Schmitz Fernando Tatsch Maribel Rodriguez‐Torres 《Liver international》2014,34(7):e217-e228
996.
997.
Michael A. Weber MD Ernesto L. Schiffrin MD William B. White MD Samuel Mann MD Lars H. Lindholm MD John G. Kenerson MD John M. Flack MD Barry L. Carter Pharm D Barry J. Materson MD C. Venkata S. Ram MD Debbie L. Cohen MD Jean‐Claude Cadet MD Roger R. Jean‐Charles MD Sandra Taler MD David Kountz MD Raymond R. Townsend MD John Chalmers MD Agustin J. Ramirez MD George L. Bakris MD Jiguang Wang MD Aletta E. Schutte MD John D. Bisognano MD Rhian M. Touyz MD Dominic Sica MD Stephen B. Harrap MD 《Journal of clinical hypertension (Greenwich, Conn.)》2014,16(1):14-26
998.
A MicroRNA-Based Test Improves Endoscopic Ultrasound–Guided Cytologic Diagnosis of Pancreatic Cancer
Randall E. Brand Alex T. Adai Barbara A. Centeno Linda S. Lee George Rateb Shivakumar Vignesh Charles Menard Anna Wiechowska–Kozłowska Hubert Bołdys Marek Hartleb Michael K. Sanders Johanna B. Munding Andrea Tannapfel Stephan A. Hahn Ludomir Stefańczyk Gregory J. Tsongalis David C. Whitcomb Darwin L. Conwell Jean A. Morisset Timothy B. Gardner Stuart R. Gordon Arief A. Suriawinata Maura B. Lloyd Dennis Wylie Emmanuel Labourier Bernard F. Andruss Anna E. Szafranska–Schwarzbach 《Clinical gastroenterology and hepatology》2014,12(10):1717-1723
999.
Annie M. Cushing Jean S. Ker Paul Kinnersley Pascal McKeown Jonathan Silverman John Patterson Olwyn M.R. Westwood 《Patient education and counseling》2014
Objective
Global migration of healthcare workers places responsibility on employers to comply with legal employment rights whilst ensuring patient safety remains the central goal. We describe the pilot of a communication assessment designed for doctors who trained and communicated with patients and colleagues in a different language from that of the host country. It is unique in assessing clinical communication without assessing knowledge.Methods
A 14-station OSCE was developed using a domain-based marking scheme, covering professional communication and English language skills (speaking, listening, reading and writing) in routine, acute and emotionally challenging contexts, with patients, carers and healthcare teams. Candidates (n = 43), non-UK trained volunteers applying to the UK Foundation Programme, were provided with relevant station information prior to the exam.Results
The criteria for passing the test included achieving the pass score and passing 10 or more of the 14 stations. Of the 43 candidates, nine failed on the station criteria. Two failed the pass score and also the station criteria. The Cronbach's alpha coefficient was 0.866.Conclusion
This pilot tested ‘proof of concept’ of a new domain-based communication assessment for non-UK trained doctors.Practice implications
The test would enable employers and regulators to verify communication competence and safety in clinical contexts, independent of clinical knowledge, for doctors who trained in a language different from that of the host country. 相似文献1000.
Kang-Hoon Lee HyungChul Rah Tajia Green Young-Kwan Lee Debora Lim Jean Nemzek Wendy Wahl David Greenhalgh Kiho Cho 《Experimental and molecular pathology》2014
Genes constitute ~ 3% of the human genome, whereas human endogenous retroviruses (HERVs) represent ~ 8%. We examined post-burn HERV expression in patients' blood cells, and the inflammatory potentials of the burn-associated HERVs were evaluated. Buffy coat cells, collected at various time points from 11 patients, were screened for the expression of eight HERV families, and we identified their divergent expression profiles depending on patient, HERV, and time point. The population of expressed HERV sequences was patient-specific, suggesting HERVs' inherent genomic polymorphisms and/or differential expression potentials depending on characteristics of patients and courses of injury response. Some HERVs were shared among the patients, while the others were divergent. Interestingly, one burn-associated HERV gag gene from a patient's genome induced IL-6, IL-1β, Ptgs-2, and iNOS. These findings demonstrate that injury stressors initiate divergent HERV responses depending on patient, HERV, and disease course and implicate HERVs as genetic elements contributing to polymorphic injury pathophysiology. 相似文献