全文获取类型
收费全文 | 1781篇 |
免费 | 114篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 43篇 |
妇产科学 | 40篇 |
基础医学 | 240篇 |
口腔科学 | 32篇 |
临床医学 | 320篇 |
内科学 | 351篇 |
皮肤病学 | 17篇 |
神经病学 | 148篇 |
特种医学 | 28篇 |
外科学 | 184篇 |
综合类 | 19篇 |
一般理论 | 7篇 |
预防医学 | 217篇 |
眼科学 | 27篇 |
药学 | 122篇 |
中国医学 | 1篇 |
肿瘤学 | 76篇 |
出版年
2023年 | 17篇 |
2022年 | 12篇 |
2021年 | 37篇 |
2020年 | 25篇 |
2019年 | 51篇 |
2018年 | 46篇 |
2017年 | 31篇 |
2016年 | 33篇 |
2015年 | 36篇 |
2014年 | 61篇 |
2013年 | 97篇 |
2012年 | 141篇 |
2011年 | 156篇 |
2010年 | 85篇 |
2009年 | 73篇 |
2008年 | 112篇 |
2007年 | 136篇 |
2006年 | 97篇 |
2005年 | 107篇 |
2004年 | 111篇 |
2003年 | 101篇 |
2002年 | 111篇 |
2001年 | 18篇 |
2000年 | 19篇 |
1999年 | 17篇 |
1998年 | 16篇 |
1997年 | 13篇 |
1996年 | 15篇 |
1995年 | 21篇 |
1994年 | 10篇 |
1993年 | 10篇 |
1992年 | 13篇 |
1991年 | 7篇 |
1990年 | 9篇 |
1989年 | 6篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1978年 | 5篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1968年 | 1篇 |
1965年 | 1篇 |
1962年 | 1篇 |
1907年 | 1篇 |
排序方式: 共有1900条查询结果,搜索用时 31 毫秒
51.
Eric S. Rothstein MD Terrence D. Welch MD Bruce W. Andrus MD John E. Jayne MD 《Catheterization and cardiovascular interventions》2021,97(3):E333-E338
The coronavirus disease-2019 (COVID-19) is a viral illness with heterogenous clinical manifestations, ranging from mild symptoms to severe acute respiratory distress syndrome and shock caused by the severe acute respiratory syndrome coronavirus-2. The global healthcare community is rapidly learning more about the effects of COVID-19 on the cardiovascular system, as well as the strategies for management of infected patients with cardiovascular disease. There is minimal literature available surrounding the relationship between COVID-19 infection and acute coronary syndrome. We describe the case of a woman who presented with an acute anterior ST-elevation myocardial infarction managed by primary percutaneous coronary intervention, who subsequently developed severe COVID-19 infection and ultimately succumbed to multisystem organ failure. 相似文献
52.
53.
Alicia M Neu Marlene R Miller Jayne Stuart John Lawlor Troy Richardson Karen Martz Carol Rosenberg Jason Newland Nancy McAfee Brandy Begin Bradley A. Warady for the SCOPE Collaborative Participants 《Pediatric nephrology (Berlin, Germany)》2014,29(9):1477-1484
The Standardizing Care to Improve Outcomes in Pediatric End Stage Renal Disease (SCOPE) Collaborative is a North American multi-center quality transformation effort whose primary aim is to minimize exit-site infection and peritonitis rates among pediatric chronic peritoneal dialysis patients. The project, developed by the quality improvement faculty and staff at the Children’s Hospital Association’s Quality Transformation Network (QTN) and content experts in pediatric nephrology and pediatric infectious diseases, is modeled after the QTN’s highly successful Pediatric Intensive Care Unit and Hematology-Oncology central line-associated blood-stream infection (CLABSI) Collaboratives. Like the Association’s other QTN efforts, the SCOPE Collaborative is part of a broader effort to assist pediatric nephrology teams in learning about and using quality improvement methods to develop and implement evidence-based practices. In addition, the design of this project allows for targeted research that builds on high-quality, ongoing data collection. Finally, the project, while focused on reducing peritoneal dialysis catheter-associated infections, will also serve as a model for future pediatric nephrology projects that could further improve the quality of care provided to children with end stage renal disease. 相似文献
54.
Paurnima Patil Agata Cieslak Stephan H. Bernhart Umut H. Toprak Rabea Wagener Cristina Lpez Laura Wiehle Susanne Bens Janine Altmüller Marek Franitza Ingrid Scholz Sandrine Jayne Matthew J. Ahearne Annika Scheffold Billy M. C. Jebaraj Christof Schneider Dolors Costa Till Braun Alexandra Schrader Elias Campo Martin J. S. Dyer Peter Nürnberg Jan Dürig Patricia Johansson Sebastian Bttcher Matthias Schlesner Marco Herling Stephan Stilgenbauer Elizabeth Macintyre Reiner Siebert 《Genes, chromosomes & cancer》2020,59(4):261-267
55.
Elisa De Franco Ccile Saint‐Martin Klaus Brusgaard Amy E. Knight Johnson Lydia Aguilar‐Bryan Pamela Bowman Jean‐Baptiste Arnoux Annette Rnholt Larsen May Sanyoura Siri Atma W. Greeley Raúl Calzada‐Len Bradley Harman Jayne A. L. Houghton Elisa Nishimura‐Meguro Thomas W. Laver Sian Ellard Daniela del Gaudio Henrik Thybo Christesen Christine Bellann‐Chantelot Sarah E. Flanagan 《Human mutation》2020,41(5):884-905
The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP‐sensitive potassium channel, a key component of the glucose‐stimulated insulin secretion pathway. Mutations in the two genes cause dysregulated insulin secretion; inactivating mutations cause an oversecretion of insulin, leading to congenital hyperinsulinism, whereas activating mutations cause the opposing phenotype, diabetes. This review focuses on variants identified in ABCC8 and KCNJ11, the phenotypic spectrum and the treatment implications for individuals with pathogenic variants. 相似文献
56.
Genome sequencing has revolutionized the way in which we approach biological research from fundamental molecular biology to ecology and epidemiology. In the last 10 years the field of genomics has changed enormously as technology has improved and the tools for genomic sequencing have moved out of a few dedicated centers and now can be performed on bench-top instruments. In this review we will cover some of the key discoveries that were catalyzed by some of the first genome projects and discuss how this field is developing, what the new challenges are and how this may impact on research in the near future. 相似文献
57.
Johanne Martel-Pelletier Robert Mccollum John Dibattista Marie-Pierre Faure Jayne A. Chin Sylvie Fournier Marika Sarfati Jean-Pierre Pelletier 《Arthritis \u0026amp; Rheumatology》1992,35(5):530-540
Objective. To identify and investigate the kinetic binding properties of interleukin-1 receptors (IL-1R), and examine the abilities of the 2 IL-1 isoforms to stimulate metalloprotease synthesis, in normal and osteoarthritic (OA) chondrocytes. Methods. Receptor affinity and density were determined using radioligand binding experiments and flow cytometry. Immunocytochemical analysis and affinity cross-linking studies were performed for characterization of IL-1R. Results. While no difference in receptor affinity between normal and OA chondrocytes was noted in binding studies (kd ˜30 pM), a 2-fold increase in receptor density was found in OA chondrocytes as compared with normal chondrocytes (mean 4,069 sites/cell versus 2,315 sites/cell). Flow cytometry experiments also showed a significant increase in receptor density in OA cells, as well as an enhancement in the percentage of positive cells in diseased cartilage compared with normal. Binding data for both IL-1 isoforms revealed a single class of binding sites and receptor specificity. Factors such as IL-2, interferon-sγ, tumor necrosis factor α, and bovine insulin did not compete with IL-1β. By covalent ligand cross-linking and electrophoretic analysis, only type I IL-1R, a protein of 80 kd, was detected on chondrocytes. By immunocytochemical analysis, IL-1R was identified at the cell membrane level, in both normal and OA chondrocytes. The presence of nuclear staining was also observed, but only in OA chondrocytes. Recombinant human IL-1 (α and β) induced the secretion of stromelysin and collagenase in a dose-dependent manner. The IL-1 concentration required for half-maximal metalloprotease stimulation was 3–4 times lower in OA chondrocytes than in normal cells. Conclusion. These results indicate that OA chondrocytes have a higher sensitivity to the stimulation of metalloprotease synthesis by IL-1 than do normal cells. This could be related to the increased levels of IL-1R expressed in the OA cells. The implications of these findings with regard to the possible roles of IL-1 and IL-1R in the pathogenesis of OA are discussed. 相似文献
58.
59.
Medium‐term oncological outcomes for extended vs saturation biopsy and transrectal vs transperineal biopsy in active surveillance for prostate cancer
下载免费PDF全文
![点击此处可从《BJU international》网站下载免费的PDF全文](/ch/ext_images/free.gif)
60.