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排序方式: 共有847条查询结果,搜索用时 140 毫秒
841.
Anne Krijger Sovianne ter Borg Liset Elstgeest Caroline van Rossum Janneke Verkaik-Kloosterman Elly Steenbergen Hein Raat Koen Joosten 《Nutrients》2022,14(14)
Screening of children’s lifestyle, including nutrition, may contribute to the prevention of lifestyle-related conditions in childhood and later in life. Screening tools can evaluate a wide variety of lifestyle factors, resulting in different (risk) scores and prospects of action. This systematic review aimed to summarise the design, psychometric properties and implementation of lifestyle screening tools for children in community settings. We searched the electronic databases of Embase, Medline (PubMed) and CINAHL to identify articles published between 2004 and July 2020 addressing lifestyle screening tools for children aged 0–18 years in the community setting. Independent screening and selection by two reviewers was followed by data extraction and the qualitative analysis of findings. We identified 41 unique lifestyle screening tools, with the majority addressing dietary and/or lifestyle behaviours and habits related to overweight and obesity. The domains mostly covered were nutrition, physical activity and sedentary behaviour/screen time. Tool validation was limited, and deliberate implementation features, such as the availability of clear prospects of actions following tool outcomes, were lacking. Despite the multitude of existing lifestyle screening tools for children in the community setting, there is a need for a validated easy-to-administer tool that enables risk classification and offers specific prospects of action to prevent children from adverse health outcomes. 相似文献
842.
843.
Tatiana Hamadeh Perry T. C. van Doormaal Mariëlle H. J. Pruppers Johannes P. M. van de Mortel Janneke G. J. Hoeijmakers David R. Cornblath Alexander F. J. E. Vrancken Catharina G. Faber Nicolette C. Notermans Ingemar S. J. Merkies the IMAGiNe Consortium 《Journal of the peripheral nervous system : JPNS》2023,28(2):269-275
844.
Effectiveness and safety of tofacitinib for ulcerative colitis: two-year results of the ICC Registry
Tessa Straatmijer Fiona D. M. van Schaik Alexander G. L. Bodelier Marijn Visschedijk Annemarie C. de Vries Cyriel Y. Ponsioen Marieke Pierik Ad A. van Bodegraven Rachel L. West Nanne K. H. de Boer Nidhi Srivastava Tessa E. H. Romkens Jildou Hoekstra Bas Oldenburg Gerard Dijkstra Janneke C. van der Woude Mark Löwenberg Zlatan Mujagic Vince B. C. Biemans Andrea E. van der Meulen-de Jong Marjolijn Duijvestein 《Alimentary pharmacology & therapeutics》2023,57(1):117-126
845.
Sandrine Nugteren Ytje Simons-Oosterhuis Celia L. Menckeberg Danielle H. Hulleman-van Haaften Dicky J. Lindenbergh-Kortleve Janneke N. Samsom 《European journal of immunology》2023,53(2):2249964
In the intestine, epithelial factors condition incoming immune cells including monocytes to adapt their threshold of activation and prevent undesired inflammation. Colonic epithelial cells express Secretory Leukocyte Protease Inhibitor (SLPI), an inhibitor of NF kappa light chain enhancer of activated B cells (NF-κB) that mediates epithelial hyporesponsiveness to microbial stimuli. Uptake of extracellular SLPI by monocytes has been proposed to inhibit monocyte activation. We questioned whether monocytes can produce SLPI and whether endogenous SLPI can inhibit monocyte activation. We demonstrate that human THP-1 monocytic cells produce SLPI and that CD68+ SLPI-producing cells can be detected in human intestinal lamina propria. Knockdown of SLPI in human THP-1 cells significantly increased NF-κB activation and subsequent C-X-C motif chemokine ligand 8 (CXCL8) and TNF-α production in response to microbial stimulation. Reconstitution of SLPI-deficient cells with either full-length SLPI or SLPI lacking its signal peptide rescued inhibition of NF-κB activation and cytokine production, demonstrating that endogenous SLPI inhibits monocytic cell activation. Unexpectedly, exogenous SLPI did not inhibit CXCL8 or TNF-α production, despite efficient uptake. Our data argue that endogenous SLPI can regulate the threshold of activation in monocytes, thereby preventing activation by commensal bacteria in mucosal tissues. 相似文献
846.
Neurological and (neuro)psychological sequelae in intensive care and general ward COVID-19 survivors
Simona Klinkhammer Janneke Horn Annelien A. Duits Johanna M. A. Visser-Meily Esmée Verwijk Arjen J. C. Slooter Alida A. Postma Caroline M. van Heugten NeNeSCo Study Group 《European journal of neurology》2023,30(7):1880-1890