The impact of breast scarring on perceptions of attractiveness: an experimental study

This study explored whether breast scarring following a lumpectomy generated negative judgements using an experimental between subjects factorial design. Eight images of women varying in terms of breast scarring (present vs. absent), beauty (average vs. high) and celebrity (as a proxy for familiarity; present vs. absent) were rated by 232 participants. The results showed that scarring resulted in lower ratings of attractiveness and self esteem and higher ratings of femininity. Scarred celebrities were judged as particularly unattractive. Women's assumption that they will be judged more harshly following breast cancer surgery maybe reflected in the actual ratings of others.     

Measurement of the humoral immune response following an incident human papillomavirus type 16 or 18 infection in young women by a pseudovirion-based neutralizing antibody assay

We have evaluated a neutralizing antibody assay which uses human papillomavirus (HPV) type 16 (HPV-16) and HPV-18 pseudovirions carrying a secretory alkaline phosphatase reporter gene and which can potentially measure functionally relevant HPV type-specific neutralizing antibodies. The reproducibility of the assay was excellent; for HPV-16, the intra- and interassay kappa values were 0.95 and 0.90, respectively; and for HPV-18, the corresponding values were 0.90 and 0.90. This assay was used to describe the kinetics of the neutralizing antibody response in a cohort of 42 young women who were recruited soon after first intercourse and who first tested positive for HPV-16 DNA or HPV-18 DNA, or both, during follow-up. Most women seroconverted following the first detection of type-specific HPV DNA and remained seropositive until the end of follow-up. Our findings are broadly consistent with those of two other cohort studies which have measured the serological response following an incident infection by using the technically simpler virus-like-particle-based enzyme-linked immunosorbent assay.     

Systematic review of massage intervention for adult patients with cancer: a methodological perspective

Findings from studies of massage, one of the most commonly used nonpharmacological nursing interventions for managing cancer pain, are inconsistent. The purpose of this article was to elucidate the methodological underpinnings of these inconsistencies with a systematic review of study design, methods, and massage efficacy in adult patients with cancer. A total of 15 studies published in English between 1986 and 2006 were identified by searching in 6 electronic databases. An author-developed tool and an adapted assessment tool were used to extract information from each study and examine the quality of reviewed studies. Methodological issues that potentially account for discrepancies across studies included less rigorous inclusion criteria, failure to consider potential confounding variables, less than rigorous research designs, inconsistent massage doses and protocols, measurement errors related to sensitivity of instruments and timing of measurements, and inadequate statistical power. Areas for future study include determination of appropriate cutoff values of selected outcome measures, delivery of equal doses along with standardized massage protocols, examination of length of massage effects over time, and use of single-blinding randomized clinical trials with large sample sizes.     

Valuing autonomy, struggling for an identity and a collective voice, and seeking role recognition: community mental health nurses' perceptions of their roles

Leaders in this community mental health system approached the problem of job frustration, morale issues, and turnover concerns of their Community Mental Health Nurses (CMHNs) by designing a qualitative study using Participant Action Research (PAR) methodology based on the philosophy of Habermas. Six focus groups were conducted to address the nurses' concerns. The themes of Valuing Autonomy, Struggling for an Identity and Collective Voice, and Seeking Role Recognition best explained the participants' concerns. The study concluded with an action plan, the implementation of the plan, and a discussion of the plan's final outcomes.     

HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options

Lipodystrophy (LD) is a common adverse effect of HIV treatment with highly active antiretroviral therapy, which comprises morphological and metabolic changes. The underlying mechanisms for LD are thought to be due to mitochondrial toxicity and insulin resistance, which results from derangements in levels of adipose tissue-derived proteins (adipocytokines) that are actively involved in energy homeostasis. Several management strategies for combating this syndrome are available, but they all have limitations. They include: switching from thymidine analogues to tenofovir or abacavir in lipoatrophy, or switching from protease inhibitors associated with hyperlipidaemia to a protease-sparing option; injection into the face with either biodegradable fillers such as poly-L-lactic acid and hyaluronic acid (a temporary measure requiring re-treatment) or permanent fillers such as bio-alcamid (with the risk of foreign body reaction or granuloma formation); and structured treatment interruption with the risk of loss of virological control and disease progression. There is therefore a need to explore alternative therapeutic options. Some new approaches including adipocytokines, uridine supplementation, glitazones, growth hormone (or growth hormone-releasing hormone analogues), metformin and statins (used alone or in combination) merit further investigation.     

The effect of nurse champions on compliance with Keystone Intensive Care Unit Sepsis-screening protocol

Sepsis poses a major threat to patient safety in intensive care units (ICU) across the country. An accumulating body of evidence supports using established protocols to screen ICU patients regularly for sepsis indicators; however, there often is a gap between what is known and what is practiced. Compliance with sepsis screening was noted to be less than acceptable at one Regional Michigan Medical Center. The 2-fold purpose of this study was to evaluate the effect of introducing nurse champions into an ICU environment on (1) ICU nurses' compliance with Michigan Health and Hospital Association Keystone ICU sepsis screening protocols and (2) patient safety outcomes. A 1-group pretest-posttest quasi-experimental design was used for the study. A nonprobability, convenience sample of patient charts from a 16-bed ICU in a 352-bed regional referral center was used for the study. Findings from this study demonstrated that the introduction of nurse champions significantly improved compliance with ICU sepsis screening, from 23% preintroduction to 74% postintroduction, but had virtually no effect on patient outcomes related to percentage of patients treated for sepsis.