新烯二炔类大分子抗肿瘤抗生素C1027的分子构成与活性关系

C1027是含烯二炔发色团的大分子肽类新抗肿瘤抗生素,由一个蛋白和一个烯二炔发色团两部分构成。后者是活性部分,对肿瘤细胞有强杀伤作用,蛋白对发色团的活性有保护作用。蛋白和发色团在一定条件下可以重新组建成完整的C1027。C1027分子内的二硫键有辅助蛋白保护发色团的作用,当二硫键被还原后,C1027活性丢失加快。C1027被链霉蛋白酶降解产生一个分子量为3～5kDa的中间产物,此产物对肿瘤细胞的杀伤作用与完整C1027相同,表明C1027是可以裁剪的,保护发色团的最小肽段为3～5kDa。     

Baseline executive functioning moderates treatment-related changes in quality of life in veterans with posttraumatic stress disorder and comorbid traumatic brain injury

Posttraumatic stress disorder (PTSD) treatment has been associated with improvement in quality of life (QOL); however, little is known about factors that moderate treatment-related changes in QOL, particularly cognitive factors. Executive functioning (EF) is important for success across all aspects of everyday life and predicts better psychological and physical health. EF is important to QOL, but more work is needed to better understand the association between EF and QOL improvements following interventions. We hypothesized that poorer baseline EF would be associated with less improvement in overall life satisfaction and satisfaction with health following PTSD treatment. U.S. veterans who served after the September 11, 2001 terrorist attacks (post 9–11; N = 80) with PTSD and a history of mild-to-moderate traumatic brain injury were randomized to standard cognitive processing therapy (CPT) or CPT combined with cognitive rehabilitation (SMART-CPT). Multilevel modeling was used to examine whether baseline EF performance was associated with changes in QOL scores from pretreatment to follow-up across both groups. Results indicated that poorer baseline performance on EF tests of working memory and inhibition were associated with less treatment-related improvements in general life satisfaction and satisfaction with health, rs = .26–.36. Treatment condition did not moderate any results. Future research should examine whether implementing EF-focused techniques before and/or concurrently with CPT for individuals with poorer baseline working memory and inhibition enhances QOL treatment gains, particularly in terms of general life and health-related satisfaction.