THE EFFECT OF DIGESTIVE JUICES ON THE POTENCY OF BOTULINUS TOXIN

Botulinus toxin resists a degree of acidity equivalent to that of the stomach even when exposed thereto for 24 hours at 37°C. It is less resistant to alkali, however, as shown by the fact that in a medium of weakly alkaline reaction its potency is reduced to less than one-tenth in 24 hours. It is unaffected by peptic and tryptic digestion. Because of its instability in mildly alkaline solutions and resistance to acid, there is reason to believe that the toxin is in the main absorbed from the upper portion of the digestive tract; that is to say, from the stomach and upper duodenum.     

Ueber die Summation heliotropischer und geotropischer Wirkungen bei den auf der Drehscheibe ausgelösten compensatorischen Kospfbewegungen

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Ueber die Hervorrufung der Membranbildung beim Seeigelei durch das Blut gewisser Würmer (Sipunculiden)

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Weitere Bemerkungen zur Theorie der antagonistischen Salzwirkungen

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Ueber Befruchtung,künstliche Parthenogenese und Cytolyse des Seeigeleis

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Chemically induced tubal occlusion in the human female using intrauterine instillation of quinacrine.

Thirty healthy volunteers, 30 years and older, received one or more intrauterine instillations of quinacrine (1 gm) in order to obtain a chemically induced occlusion of the Fallopian tubes. Prior patency of the latter was checked either by the Rubin test or by hysterosalpingography (in 8 patients). Bilateral occlusion occurred in 12 patients after the first instillation; this was shown by the Rubin test, done for all subjects 4 to 6 weeks after the procedure, and by hysterosalpingography in 11 out of the 12 patients with a negative Rubin test. From the remaining 17 volunteers (one opted out), 11 cases of occlusion were obtained after a second instillation. Three patients received a third instillation, with positive results in two. Thus bilateral occlusion was produced in 25 out of the 30 referred patients. So far 11 patients were seen in follow-up 6 to 8 months after the last instillation; in all cases hysterosalpingography confirmed the long lasting state of occlusion.     

Weitere Untersuchungen über die entgiftenden Ionenwirkungen und die Rolle der Werthigkeit der Kationen bei diesen Vorgängen

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Physiologische Untersuchungen über Ionenwirkungen

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