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Bani Sadr Alexandre Gregoire Bastien Tordo Jeremie Guyotat Jacques Boibieux Andre Janier Marc 《Annals of nuclear medicine》2019,33(6):424-433
Annals of Nuclear Medicine - Currently, the diagnosis of bone flap osteomyelitis (BFO) remains a challenge for medical imaging. The present study aimed to identify predictive scintigraphic patterns... 相似文献
994.
Tauty Alban Noblet Vincent Paillard Catherine Fornecker Luc-Matthieu Namer Izzie Jacques Bund Caroline 《Annals of nuclear medicine》2019,33(8):564-569
Annals of Nuclear Medicine - Chemobrain is a recently proposed pathological entity. 18F-FDG PET/CT can show objective abnormalities to explain brain disorders caused by chemotherapy, although no... 相似文献
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Turati Marco Bigoni Marco Brahim Lilia Bourgeois Emeline Zatti Giovanni Eid Ahmad Griffet Jacques Courvoisier Aurélien 《Sport Sciences for Health》2019,15(1):207-213
Sport Sciences for Health - Unicameral bone cyst (UBC) is a common lesion in skeletally immature patients. Multiple treatments are proposed as curettage and autologous bone graft, percutaneous... 相似文献
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Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non‐small‐Cell Lung Cancer Receiving Erlotinib Treatment 下载免费PDF全文
Zinnia P. Parra‐Guillen Peter B. Berger Manuel Haschke Massimiliano Donzelli Daria Winogradova Bogumila Pfister Martin Früh Silke Gillessen Stephan Krähenbühl Markus Joerger 《Basic & clinical pharmacology & toxicology》2017,121(4):309-315
Erlotinib is metabolized by cytochrome p450 (CYP) 3A and CYP1A. This study assessed CYP3A4 (midazolam) and CYP1A2 (caffeine) phenotyping in plasma and dried blood spots (DBS) for predicting the pharmacokinetics and toxicity of erlotinib in 36 patients with advanced NSCLC. On day 1, erlotinib 150 mg OD was initiated, and the two oral probe drugs midazolam (2 mg) and caffeine (100 mg) were added on day 1. Plasma and DBS were collected for erlotinib, OSI‐420 and probe drugs for up to 6 hr on day 1 and 2‐weekly up to week 10. Probe drugs, erlotinib and OSI‐420 were analysed using LC‐MS‐MS, and PK data were processed using population modelling. A high correlation was found between plasma and DBS concentrations for erlotinib (R2 = 0.960, p < 0.0001), OSI‐420 (R2 = 0.971, p < 0.0001), midazolam (R2 = 0.995, p < 0.0001) and caffeine (R2 = 0.968, p < 0.0001). Apparent oral caffeine clearance was significantly correlated with erlotinib clearance (R2 = 0.33, p = 0.048), while midazolam clearance was not (R2 = ?0.09, p = 0.596). Erlotinib clearance was lower in patients experiencing grade 2 or 3 rash as compared to patients experiencing grade 0 or 1 rash (3.15 versus 3.93 L/hr, p = 0.086 for Student's t‐test). The results suggest that probe drug phenotyping is unlikely to substitute therapeutic drug monitoring of erlotinib in patients with advanced NSCLC, but erlotinib PK sampling from DBS may replace more invasive venous sampling and facilitate TDM in patients with cancer. 相似文献
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A run-in is a period prior to randomization during which potential participants who have met all entry criteria for a randomized clinical trial are assigned the same regimen, either the control (possibly placebo) or the experimental treatment. Typically, the intention is to exclude from the subsequent study (i.e., randomization) some segment of this cohort, based on their experiences during the run-in period. Selecting patients based on the run-in thereby forces differential representation of certain subpopulations relative to others. Previous studies have addressed the potential for a run-in to jeopardize validity through unintended mechanisms. While these concerns are valid, they leave open the possibility that modifications to the design of the run-in might be able to preserve validity, even if patient selection is based on the results of the run-in. As such, we address the potential for selecting patients based on response during a run-in period to jeopardize validity directly, through its intended effect of overrepresenting (relative to the screened population) some segments in the randomized portion of the trial and underrepresenting others. 相似文献
999.
Leonardo Vidal Andreato Eloa Jacques Pastório Solange Marta Franzói de Moraes João Victor Del Conti Esteves Valéria Leme Gonçalves Panissa Ursula Ferreira Julio Emerson Franchini 《Sport Sciences for Health》2016,12(2):183-188
Purpose
To analyze the hydroelectrolytic balance of Brazilian jiu-jitsu athletes during a simulated competition.Methods
Eight athletes were analyzed in simulated competition (four matches of 10 min). Blood lactate and rating of perceived exertion (6–20 scale) were used to infer the intensity of the matches. Blood samples were taken to determine the serum levels of osmolality, total protein and some electrolytes (chlorides, sodium, potassium, calcium, magnesium, phosphorus and iron).Results
The lactate concentration changed during the simulated competition (F 7.49 = 35.5; P < 0.001; η 2 = 0.85), with an increase post-match compared to the pre-match in matches 1, 2 and 4, but not for match 3. For rating of perceived exertion, no changes were found during the competition (F 3.21 = 9.4; P = 0.440; η 2 = 0.12). The matches did not change the osmolality, chlorides, sodium, potassium, magnesium and iron values. For total protein, a difference was observed between the time-points (F 2.8; 19.6 = 4.6; P = 0.015; η 2 = 0.40), with lower concentrations in pre-match 2 than pre-match 1, post-matches 2 and 3. The calcium concentration was also affected by the simulated competition (F 7.49 = 4.0; P = 0.002; η 2 = 0.37), with values lower in pre-match 2 than post-matches 1 and 2. The phosphorus serum was changed by matches (F 3.1; 21.7 = 18.6; P < 0.001; η 2 = 0.73), with post-match 1 values higher than the pre-matches 1, 2, 3 and 4 and post-match 3. The pre-match 4 values were lower than post-matches 2 and 4.Conclusion
Although there were some changes during simulated competition, important alterations in the hydroelectrolytic balance did not occur.1000.