全文获取类型
收费全文 | 1065篇 |
免费 | 42篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 36篇 |
妇产科学 | 47篇 |
基础医学 | 193篇 |
口腔科学 | 23篇 |
临床医学 | 52篇 |
内科学 | 271篇 |
皮肤病学 | 16篇 |
神经病学 | 106篇 |
特种医学 | 7篇 |
外科学 | 55篇 |
综合类 | 6篇 |
预防医学 | 102篇 |
眼科学 | 19篇 |
药学 | 103篇 |
中国医学 | 1篇 |
肿瘤学 | 49篇 |
出版年
2024年 | 2篇 |
2023年 | 9篇 |
2022年 | 78篇 |
2021年 | 95篇 |
2020年 | 23篇 |
2019年 | 27篇 |
2018年 | 28篇 |
2017年 | 26篇 |
2016年 | 26篇 |
2015年 | 24篇 |
2014年 | 32篇 |
2013年 | 50篇 |
2012年 | 79篇 |
2011年 | 92篇 |
2010年 | 50篇 |
2009年 | 37篇 |
2008年 | 60篇 |
2007年 | 66篇 |
2006年 | 66篇 |
2005年 | 52篇 |
2004年 | 54篇 |
2003年 | 49篇 |
2002年 | 34篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 6篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 3篇 |
1991年 | 1篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1984年 | 1篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1973年 | 5篇 |
1972年 | 4篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1967年 | 1篇 |
1966年 | 1篇 |
1965年 | 6篇 |
排序方式: 共有1112条查询结果,搜索用时 0 毫秒
91.
Kowalewska-Pietrzak M Klich I Mlynarski W 《Pediatric nephrology (Berlin, Germany)》2008,23(12):2195-2200
The aim of this study was to assess the association between the transforming growth factor-β1 (TGF-β1) gene polymorphisms rs1800469 (commonly known as T-509C) and rs1982073 (commonly known as Leu 10→Pro) and primary vesicoureteral reflux (VUR) and renal scarring. Using a case–control approach, we examined 121 children
with primary VUR and 169 controls. Genotyping of the TGF-β1 gene polymorphisms was performed by restriction fragment length polymorphism (RFLP) analysis. The 99mTc-DMSA– or 99mTc-unitiol–single photon emission computed tomography method was used to evaluate renal scars in 84 of 121 VUR children. Statistical
analysis revealed differences in rs1800469 genotype frequencies between VUR patients and controls (p = 0.0021). Our data demonstrate that individuals homozygous for the TT genotype are at risk of primary VUR [odds ratio (95%
confidence interval) = 2.7 (1.46–5.08)]. Distribution of the rs1982073 polymorphism was similar in VUR children and controls.
In terms of renal scarring, patients were stratified into non-scar and scar subgroups, and no differences in the genotype
frequencies of either polymorphism was found. Previous reports have shown that the TT genotype of the rs1800469 polymorphism
is a risk factor for renal scarring in primary VUR, and the results of our study suggest that this same polymorphism is associated
with susceptibility to this congenital uropathy. 相似文献
92.
93.
94.
Izabela Hartman Alison R. Gillies Sonia Arora Christina Andaya Nitya Royapet William J. Welsh David W. Wood Randy J. Zauhar 《Pharmaceutical research》2009,26(10):2247-2258
Purpose
In this study, two unreported estrogen antagonists were identified using a combination of computational screening and a simple bacterial estrogen sensor. 相似文献95.
Dwornik M Białoszewski D Korabiewska I Wroński Z 《Ortopedia, traumatologia, rehabilitacja》2007,9(2):111-121
Neuro mobilization is a method of conservative treatment of disorders of neural tissue. The rationale for using neuro mobilization in the treatment of musculoskeletal conditions is based on in vivo and in vitro studies which point to a high efficacy of neuro mobilization procedures. Appropriate use of neuro mobilization procedures depends on excellent knowledge of normal and pathological anatomy, differences between individual etiological factors, development of disease and symptom variability. The present paper familiarizes the reader with evidence-based conservative treatment of musculoskeletal conditions by neuro mobilization. 相似文献
96.
Buyandelger B Ng KE Miocic S Piotrowska I Gunkel S Ku CH Knöll R 《Pflügers Archiv : European journal of physiology》2011,462(1):135-142
Muscle LIM protein (MLP, also known as cysteine rich protein 3 (CSRP3, CRP3)) is a muscle-specific-expressed LIM-only protein.
It consists of 194 amino-acids and has been described initially as a factor involved in myogenesis (Arber et al. Cell 79:221–231,
1994). MLP soon became an important model for experimental cardiology when it was first demonstrated that MLP deficiency leads
to myocardial hypertrophy followed by a dilated cardiomyopathy and heart failure phenotype (Arber et al. Cell 88:393–403,
1997). At this time, this was the first genetically altered animal model to develop this devastating disease. Interestingly, MLP
was also found to be down-regulated in humans with heart failure (Zolk et al. Circulation 101:2674–2677, 2000) and MLP mutations are able to cause hypertrophic and dilated forms of cardiomyopathy in humans (Bos et al. Mol Genet Metab
88:78–85, 2006; Geier et al. Circulation 107:1390–1395, 2003; Hershberger et al. Clin Transl Sci 1:21–26, 2008; Kn?ll et al. Cell 111:943–955, 2002; Kn?ll et al. Circ Res 106:695–704, 2010; Mohapatra et al. Mol Genet Metab 80:207–215, 2003). Although considerable efforts have been undertaken to unravel the underlying molecular mechanisms—how MLP mutations, either
in model organisms or in the human setting cause these diseases are still unclear. In contrast, only precise knowledge of
the underlying molecular mechanisms will allow the development of novel and innovative therapeutic strategies to combat this
otherwise lethal condition. The focus of this review will be on the function of MLP in cardiac mechanosensation and we shall
point to possible future directions in MLP research. 相似文献
97.
Pawel Mierzejewski Agnieszka Korkosz Artur Rogowski Izabela Korkosz Wojciech Kostowski Anna Scinska 《Progress in neuro-psychopharmacology & biological psychiatry》2009
A large body of evidence indicates that reactivation of aversive memories leads to protein synthesis-dependent memory reconsolidation which can be disrupted by cycloheximide (CHX) and other protein synthesis inhibitors. The aim of the present study was to investigate whether CHX would alter maintenance of well-trained instrumental responding for 0.1% saccharin. Male Wistar rats were trained to lever press for saccharin. When lever pressing stabilized, experimental self-administration sessions with CHX (3 mg/kg, s.c.) started. The animals received four experimental sessions, with each session separated by 5 days. The protein synthesis inhibitor was injected immediately after the experimental sessions 1–3. Repeated post-session injections of CHX did not alter saccharin self-administration. A two-bottle choice test conducted after the last experimental session revealed that CHX had not induced any conditioned taste aversion to 0.1% saccharin. The present results suggest that well-consolidated long-term memory of an appetitive instrumental task does not depend on de novo protein synthesis. 相似文献
98.
Intraneuronal Aβ immunoreactivity is not a predictor of brain amyloidosis-β or neurofibrillary degeneration 总被引:3,自引:3,他引:0
Wegiel J Kuchna I Nowicki K Frackowiak J Mazur-Kolecka B Imaki H Wegiel J Mehta PD Silverman WP Reisberg B Deleon M Wisniewski T Pirttilla T Frey H Lehtimäki T Kivimäki T Visser FE Kamphorst W Potempska A Bolton D Currie JR Miller DL 《Acta neuropathologica》2007,113(4):389-402
Amyloid β (Aβ) immunoreactivity in neurons was examined in brains of 32 control subjects, 31 people with Down syndrome, and
36 patients with sporadic Alzheimer’s disease to determine if intraneuronal Aβ immunoreactivity is an early manifestation
of Alzheimer-type pathology leading to fibrillar plaque formation and/or neurofibrillary degeneration. The appearance of Aβ
immunoreactivity in neurons in infants and stable neuron-type specific Aβ immunoreactivity in a majority of brain structures
during late childhood, adulthood, and normal aging does not support this hypothesis. The absence or detection of only traces
of reaction with antibodies against 4–13 aa and 8–17 aa of Aβ in neurons indicated that intraneuronal Aβ was mainly a product
of α- and γ-secretases (Aβ17–40/42). The presence of N-terminally truncated Aβ17–40 and Aβ17–42 in the control brains was confirmed by Western blotting and the identity of Aβ17–40 was confirmed by mass spectrometry. The prevalence of products of α- and γ -secretases in neurons and β- and γ-secretases
in plaques argues against major contribution of Aβ-immunopositive material detected in neuronal soma to amyloid deposit in
plaques. The strongest intraneuronal Aβ17–42 immunoreactivity was observed in structures with low susceptibility to fibrillar Aβ deposition, neurofibrillary degeneration,
and neuronal loss compared to areas more vulnerable to Alzheimer-type pathology. These observations indicate that the intraneuronal
Aβ immunoreactivity detected in this study is not a predictor of brain amyloidosis or neurofibrillary degeneration. The constant
level of Aβ immunoreactivity in structures free from neuronal pathology during essentially the entire life span suggests that
intraneuronal amino-terminally truncated Aβ represents a product of normal neuronal metabolism.
This study was supported in part by funds from the New York State Office of Mental Retardation and Developmental Disabilities
and grants from the National Institutes of Health (The National Institute of Child Health and Human Development R01 HD43960
and PO1 HD35897; and the National Institute of Aging P30 AG08051, AG03051, and PO1 AG11531). 相似文献
99.
100.
Friedman A Zakrzewska-Pniewska B Domitrz I Lee HY Ptacek L Kwiecinski H 《European neurology》2009,61(1):39-41
Paroxysmal non-kinesigenic dyskinesia (PNKD) is a clinical syndrome of sudden involuntary movements, mostly of dystonic type, which may be triggered by alcohol or coffee intake, stress and fatigue. The attacks of PNKD may consist of various combinations of dystonia, chorea, athetosis and balism. They can be partial and unilateral, but mostly the hyperkinetic movements are bilateral and generalized. We present a large Polish family with 7 symptomatic members of the family in 6 generations. In all affected persons, the onset of clinical symptoms was in early childhood. All male cases showed an increase in severity and frequency of the attacks with ageing, while the only living female patient noticed an improvement of PNKD during both her pregnancies and also after menopause. In addition, at the age of 55 years, she developed symptoms of Parkinson's disease with good response to levodopa treatment. 相似文献