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101.
Cardiogenic shock in the setting of acute myocardial infarction (AMI) carries significant morbidity and mortality, despite advances in pharmacological, mechanical and reperfusion therapies. Studies suggest that there is evidence of sex disparities in the risk profile, management, and outcomes of cardiogenic shock complicating AMI. Compared with men, women tend to have more comorbi dities, greater variability in symptom presentation and are less likely to receive timely revascularization and mechanical circulatory support. These factors might explain why women tend to have worse outcomes. In this review, we highlight sex-based differences in the prevalence, management, and outcomes of cardio genic shock due to AMI, and discuss potential ways to mitigate them. 相似文献
102.
Md Zohorul Islam Jesper Larsen Robert Skov Øystein Angen 《Diagnostic microbiology and infectious disease》2019,93(1):5-8
Optimal transportation of bacteria is important for accurate clinical interpretation, quantitative assays, and microbiome studies. A transport medium should ideally keep the bacteria alive without supporting growth or altering the relative proportions of the constituent species. We investigated the effect of nasal mucus and mucin on the growth and survival of two Staphylococcus aureus strains in liquid Amies transport medium at room temperature and 4?°C for 14?days. The study showed that the presence of nasal mucus in microbiological samples stimulated undesired S. aureus growth at room temperature in a dose-dependent manner. These findings underscore that microbiological samples from humans and animals should be stored at 4?°C until analysis to avoid undesired S. aureus growth. 相似文献
103.
12S,20-dihydroxyicosatetraenoic acid: a new icosanoid synthesized by neutrophils from 12S-hydroxyicosatetraenoic acid produced by thrombin- or collagen-stimulated platelets. 总被引:12,自引:2,他引:12 下载免费PDF全文
A J Marcus L B Safier H L Ullman M J Broekman N Islam T D Oglesby R R Gorman 《Proceedings of the National Academy of Sciences of the United States of America》1984,81(3):903-907
A new metabolite of arachidonic acid, formed during interaction between thrombin- or collagen-stimulated platelets and unstimulated neutrophils, has been demonstrated by both thin-layer radiochromatography and high-performance liquid chromatography. Production of the 3H-labeled metabolite in combined suspensions containing [3H]arachidonate-labeled platelets and unlabeled neutrophils from aspirin-treated donors suggested that platelet 3H-labeled 12S-hydroxy-5,8-cis,10-trans,14-cis-icosatetraenoic acid (12-HETE) was the precursor. This was confirmed by identification of the same product when purified 12-[3H]HETE was added directly to unstimulated neutrophils. Hydrogenation and oxidation of the isolated product, followed by gas chromatography-mass spectrometry showed the structure to be 12S,20-dihydroxyicosatetraenoic acid. These experiments further show that platelet stimuli known to occur in vivo may initiate metabolic interactions between different cell types via the arachidonic acid pathway. 相似文献
104.
Ljungberg K Hassan MS Islam MN Siddiqui MA Aziz MM Wahren B Islam KB Leitner T 《AIDS research and human retroviruses》2002,18(9):667-670
We analyzed the genetic diversity of HIV-1 circulating in Bangladesh by direct sequencing and subsequent phylogenetic analysis of the V3 region of the env gene and p17 fragment of the gag gene from nine unrelated patients. The sequences from one sample grouped into subtype A, five samples grouped into subtype C, and one grouped into subtype G. In addition, two patients appeared to be infected with different recombinant viruses consisting of subtype A and unclassifiable viral sequences. Epidemiological analysis revealed heterosexual transmission in the majority of cases. Furthermore, most subjects had a history of traveling, either to India or to the Arabian Peninsula. This study shows that several HIV-1 subtypes are circulating in Bangladesh, and we conclude that there must have been several introductions of HIV-1 into the Bangladeshi population. 相似文献
105.
Sunjidatul Islam Padma Kaul Dat T. Tran Andrew S. Mackie 《The Canadian journal of cardiology》2018,34(10):1289-1297
Background
Data regarding health care resource utilization (HRU) in early childhood among children with congenital heart disease (CHD) are scarce. Therefore, we sought to describe the extent of HRU incurred among children with CHD in the first 5 years of life.Methods
This population-based retrospective cohort study included all children born between January 2005 and March 2014 in Alberta, Canada. We linked inpatient, outpatient, practitioner claims, and drug dispensing databases with vital statistics (birth and death registries).Results
In the first year of life, the cumulative hospitalization rate per 100 children was 335 (95% confidence interval: 312-360) for single ventricle (SV) children, 200 (194-206) for moderate-complex CHD, and 152 (149-156) for simple CHD vs 109 (108-109) among children without CHD (P < 0.001). The ambulatory-care visit rate per 100 children was 4871 (4780-4963) for SV, 2278 (2258-2299) for moderate-complex, and 1416 (1405-1426) for simple CHD vs 246 (246-247) for children without CHD (P < 0.001). The rates of physician claims and drug dispensing also demonstrated similar patterns. The median total hospitalization length of stay during the first year of life was 54 days (interquartile range: 26-95) in SV, 15 (4-39) in moderate-complex, and 6 (2-26) in simple CHD compared with 2 (1-3) among children without CHD (P < 0.001). These differences remained throughout the first 5 years of life, with children with CHD having consistently higher hospitalization rates and emergency department visit rates in every year of age compared with children without CHD.Conclusions
Cumulative HRU is high among children with CHD in the first 5 years of life and increases with increasing CHD severity. Improving survival of SV lesions will require increasing resource allocation to this group. 相似文献106.
107.
Decrease of lung tension increases the sensitivity of the bronchial system to acetylcholine inhalation. A decrease in lung tension was achieved by pneumothorax in dogs and with a thorax bandage in human subjects. The increase of airway resistance to acetylcholine inhalation following the decrease in lung tension was understood as a change of the effectiveness of the bronchial muscles on airway resistance. Acetylcholine works via sensoric receptors through the N. vagi on the bronchial muscles. Blockade of the N. vagi prevented an increase of sensitivity in the bronchial system. Measurements and results of breathing-volume per minute, breathing frequency, and blood gases are also described. 相似文献
108.
Islam MZ Itoh M Mirza R Ahmed I Ekram AR Sarder AH Shamsuzzaman SM Hashiguchi Y Kimura E 《The American journal of tropical medicine and hygiene》2004,70(1):78-82
A new direct agglutination test (DAT) for use with urine samples for the diagnosis of visceral leishmaniasis (VL) has been developed and compared with the conventional DAT with serum samples and our previously reported enzyme-linked immunosorbent assay (ELISA) with urine samples (urine ELISA). The new DAT, in which anti-human IgG was used as enhancing antibody, was tested with urine samples from 75 VL patients and 225 non-VL patients and healthy people. The sensitivity of the new DAT (90.7%), was almost the same as that of the conventional DAT (91.0%) and the urine ELISA (93.3%). The specificity of the new DAT (96.4%) was nearly identical with that of the urine ELISA (97.3%). A urine-based DAT has several advantages over the conventional DAT: sample collection is non-invasive and it can process larger numbers of samples with smaller amounts of antigen. 相似文献
109.
Thalidomide as salvage therapy for VAD-refractory multiple myeloma prior to autologous PBSCT 总被引:2,自引:0,他引:2
Ahmad I Islam T Chanan-Khan A Hahn T Wentling D Becker JL McCarthy PL Alam AR 《Bone marrow transplantation》2002,29(7):577-580
Several trials have shown the activity of thalidomide (THAL) in relapsed multiple myeloma (MM) patients failing PBSCT or conventional chemotherapy. PBSCT is considered standard treatment for most patients requiring therapy for MM; however, patients with VAD-resistant disease may not be able to receive PBSCT due to rapidly advancing disease. We report four cases of VAD-refractory MM salvaged with THAL + VAD followed by PBSCT. All patients underwent stem cell mobilization with cyclophosphamide (Cy) (4.5 g/m(2)) and GMCSF. Melphalan (140-200 mg/m(2)) was given as conditioning. All patients engrafted within 12-16 days after PBSCT. Day +100 evaluation showed the following: very good partial response (n = 1) and complete response (n = 3). After a median follow-up to 153 days, two patients continue to take THAL with no signs of disease progression. One patient developed CHF and was taken off THAL while another patient has died of progressive disease while on THAL (MTD 50 mg). In conclusion, VAD-refractory patients were salvaged with the addition of THAL to VAD. They were subsequently able to undergo autologous PBSCT for MM, which will likely improve their overall survival. This suggests that THAL and other related immunomodulatory drugs may prove useful for initial MM therapy in combination with standard chemotherapy followed by PBSCT. 相似文献
110.
Tania Islam Maznah Dahlui Hazreen Abd Majid Azmi Mohamed Nahar Nur Aishah Mohd Taib Tin Tin Su MyBCC study group 《BMC public health》2014,14(Z3):S8