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排序方式: 共有1965条查询结果,搜索用时 31 毫秒
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E. Rosser RN DPhil MN RM Dip N Ed Dip RM PFHEA E. Buckner RN PhD CNE AE-C FNAP T. Avedissian RN MSN D.S.K. Cheung BN MSc PhD K. Eviza RN MSN T. B. Hafsteinsdóttir RN PhD M.Y. Hsu RN PhD MSc M. N. Kirshbaum RN BSc MSc PhD GDip Health Ed Dip Onc Dip Counselling Dip CBT FHEA C. Lai RN PhD Y.C. Ng PhD J. Ramsbotham RN PhD MN S. Waweru RN MSN FNP-BC 《International nursing review》2020,67(4):484-494
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Hermann Einsele MD Hossein Borghaei DO Robert Z. Orlowski MD Marion Subklewe MD Gail J. Roboz MD Gerhard Zugmaier MD Peter Kufer MD Karim Iskander MD Hagop M. Kantarjian MD 《Cancer》2020,126(14):3192-3201
Immuno-oncology therapies engage the immune system to treat cancer. BiTE (bispecific T-cell engager) technology is a targeted immuno-oncology platform that connects patients' own T cells to malignant cells. The modular nature of BiTE technology facilitates the generation of molecules against tumor-specific antigens, allowing off-the-shelf immuno-oncotherapy. Blinatumomab was the first approved canonical BiTE molecule and targets CD19 surface antigens on B cells, making blinatumomab largely independent of genetic alterations or intracellular escape mechanisms. Additional BiTE molecules in development target other hematologic malignancies (eg, multiple myeloma, acute myeloid leukemia, and B-cell non-Hodgkin lymphoma) and solid tumors (eg, prostate cancer, glioblastoma, gastric cancer, and small-cell lung cancer). BiTE molecules with an extended half-life relative to the canonical BiTE molecules are also being developed. Advances in immuno-oncology made with BiTE technology could substantially improve the treatment of hematologic and solid tumors and offer enhanced activity in combination with other treatments. 相似文献
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Iman F. Iskander Khaled M. Salama Rasha M. Gamaleldin Jerard Seghatchian 《Transfusion and apheresis science》2018,57(3):431-436
Preterm neonates represent one of the most transfused categories of patients. Their target hematocrits, however, are mainly based on expert opinion. The risk of transfusions are very high in the smallest preterm baby with a weak immune response, immature antioxidant ability, fragile germinal matrix and impaired cerebral autoregulation, yet red cell transfusions remain the only life saving measure in the baby with symptomatic anemia.Minimizing phlebotomy losses, following a restrictive transfusion policy and using screened, leukocyte depleted, irradiated, single donor blood remain the best means of avoiding the possible risks while maximizing the benefits of red cell transfusions in the preterm newborn. 相似文献
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Eriko Anzai RN MN Clint Douglas RN PhD Ann Bonner RN PhD 《Nursing & health sciences》2014,16(2):171-178
The purpose of this study was to describe Japanese hospital nurses' perceptions of the nursing practice environment and examine its association with nurse‐reported ability to provide quality nursing care, quality of patient care, and ward morale. A cross‐sectional survey design was used including 223 nurses working in 12 acute inpatient wards in a large Japanese teaching hospital. Nurses rated their work environment favorably overall using the Japanese version of the Practice Environment Scale of the Nursing Work Index. Subscale scores indicated high perceptions of physician relations and quality of nursing management, but lower scores for staffing and resources. Ward nurse managers generally rated the practice environment more positively than staff nurses except for staffing and resources. Regression analyses found the practice environment was a significant predictor of quality of patient care and ward morale, whereas perceived ability to provide quality nursing care was most strongly associated with years of clinical experience. These findings support interventions to improve the nursing practice environment, particularly staffing and resource adequacy, to enhance quality of care and ward morale in Japan. 相似文献
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Prevention of lung cancer: The key is to stop smoking 总被引:1,自引:0,他引:1
MN RN CS ANPNancy L. Risser Adult Nurse Practitioner Primary Care 《Seminars in Oncology Nursing》1996,12(4):260-269