排序方式: 共有74条查询结果,搜索用时 15 毫秒
41.
Molenaar P Rabnott G Yang I Fong KM Savarimuthu SM Li L West MJ Russell FD 《Journal of the American College of Cardiology》2002,40(7):1275-1282
OBJECTIVE: The goal of this study was to determine whether the cardiostimulant effects of the endogenous beta(1)-adrenergic receptor (AR) agonist, (-)-norepinephrine are modified by polymorphic (Serine49Glycine [Ser49Gly], Glycine389Arginine [Gly389Arg]) variants of beta(1)-ARs in the nonfailing adult human heart. BACKGROUND: Human heart beta(1)-ARs perform a crucial role in mediating the cardiostimulant effects of (-)-norepinephrine. An understanding of the significance of Ser49Gly and Gly389Arg polymorphisms in the human heart is beginning to emerge, but not as yet in adult patients who have coronary artery disease (CAD). METHODS: The potency and maximal effects of (-)-norepinephrine at beta(1)-ARs (in the presence of beta(2)-AR blockade with 50 nM ICI 118,551 [erythro-DL-1(7-methylindan-4-yloxy)-3-isopropylamino-butan-2-ol]) for changes in contractile force and shortening of contractile cycle duration were determined in human right atrium in vitro from 87 patients undergoing coronary artery bypass grafting who were taking beta-blockers before surgery. A smaller sample of patients (n = 20) not taking beta-blockers was also investigated. Genotyping for two beta(1)-AR polymorphisms (Ser49Gly and Gly389Arg) was determined from a sample of blood taken at the time of surgery. RESULTS: (-)-Norepinephrine caused concentration-dependent increases in contractile force and reductions in time to reach peak force and time to reach 50% relaxation. There were no differences in the potency or maximal effects of (-)-norepinephrine in the right atrium from patients with different Ser49Gly and Gly389Arg polymorphisms. CONCLUSIONS: The cardiostimulant effects of (-)-norepinephrine at beta(1)-ARs were conserved across Ser49Gly and Gly389Arg polymorphisms in the right atrium of nonfailing hearts from patients with CAD managed with or without beta-blockers. 相似文献
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Kenneth Blum Amanda LC Chen Thomas JH Chen Roger L Waite B William Downs Eric R Braverman Mallory M Kerner Stella M Savarimuthu Nicholas DiNubile 《BMC musculoskeletal disorders》2009,10(1):132
Background
Albeit other prospective randomized controlled clinical trials on H-Wave Device Stimulation (HWDS), this is the first randomized double-blind Placebo controlled prospective study that assessed the effects of HWDS on range of motion and strength testing in patients who underwent rotator cuff reconstruction. 相似文献44.
The anticarcinogenic potential of the phytocompound Luteolin-7-O-Glucoside (LUT7G), isolated from the leaves of Ophiorrhiza mungos Linn, was studied against 4 different cancer cell lines (COLO 320 DM, AGS, MCF-7, and A549) and normal VERO cell line. The ability of LUT7G to induce apoptosis was determined by its antiradical activity, DNA fragmentation, expression of β-catenin, and chemopreventive efficacy in vivo by administering rats with DMH (20 mg/kg b.w., s.c.) for 4 consecutive wk and supplementing with 3 different doses throughout the experimental period of 16 wk. LUT7G scavenged 80% of DPPH radicals generated in vitro at 1000 μM and suppressed the expression of β-catenin to 40% at 120 μM concentrations. LUT7G induced apoptosis by scavenging ROS and suppressing the expression of β-catenin in COLO 320 DM cells and effectively inhibited ACF development in DMH-induced experimental carcinogenesis. Hence LUT7G can be a potent anticancer drug for colon carcinogenesis. 相似文献
45.
Albert A Baskar Savarimuthu Ignacimuthu Gabriel M Paulraj Khalid S Al Numair 《BMC complementary and alternative medicine》2010,10(1):24
Background
Asclepias curassavica Linn. is a traditional medicinal plant used by tribal people in the western ghats, India, to treat piles, gonorrhoea, roundworm infestation and abdominal tumours. We have determined the protective effect of β-sitosterol isolated from A. curassavica in colon cancer, using in vitro and in vivo models. 相似文献46.
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Dhanasekaran M Baskar AA Ignacimuthu S Agastian P Duraipandiyan V 《Investigational new drugs》2009,27(4):347-355
Summary Medicinal plants are a promising source for identification of lead molecules for cancer therapy. In our continuous search
to discover bioactive compounds from natural products, we isolated (5R, 10R)-4R, 8R-dihydroxy-2S, 3R:15, 16-diepoxycleroda-13(16), 17, 12S:18,1S-dilactone (ECD), a diterpenoid from Tinospora cordifolia and studied its chemopreventive potential in diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) rats. Fifty
male Wistar rats were divided into five groups. Group I served as normal control. Group II–IV were given DEN (0.01% in drinking
water) for twenty weeks. In addition, Group III (preventive treatment) received ECD (10 mg/kg body weight) throughout the
study. Group IV (curative treatment) received ECD (10 mg/kg body weight) for the last 8 weeks. Group V received ECD alone
(10 mg/kg body weight) throughout the experimental period. At the end of the experimental period all the animals were sacrificed
and analyzed for biochemical end points to assess the effect of ECD treatment in DEN induced HCC. The animals treated with
DEN showed a decrease in the activities of antioxidant (SOD, CAT) and detoxification enzymes (GSH, GPx) with increase in the
activities of the hepatic markers (SGOT, SGPT, LDH). Treatment of ECD in both preventive and curative DEN induced animals
increased the level of antioxidants and detoxification enzymes, and decreased serum transaminase level and hepatic marker
enzymes to near normal. Histopathological and nodular incidence also confirmed that ECD remarkably reduced tumor incidence
and reversed damaged hepatocytes to normal. Our findings confirm that ECD exhibits preventive effect against chemically induced
HCC in rats. ECD can be a potent chemopreventive drug for HCC. 相似文献
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Gopalsamy Rajiv Gandhi Savarimuthu Ignacimuthu Michael Gabriel Paulraj 《Food and chemical toxicology》2011,49(11):2725-2733
In this study, quantification of phenolic compounds and the investigation of antidiabetic and antioxidant activities of the fruit of Solanum torvum Swartz. are described. S. torvum fruit methanol extract (STMe) was administered orally at a dose of 200 and 400 mg/kg/day to streptozotocin induced diabetic rats for 30 days. The levels of glucose, insulin, total protein, hemoglobin, glycated hemoglobin, liver glycogen and marker enzymes of carbohydrate metabolism, hepatic function and antioxidants were analyzed. High-performance liquid chromatography (HPLC) analysis revealed that STMe contained high levels of phenolic compounds, mainly rutin (1.36% w/w), caffeic acid (12.03% w/w), gallic acid (4.78% w/w) and catechin (0.46% w/w). STMe at 200 and 400 mg/kg reduced blood glucose level by 17.04% and 42.10%, respectively in diabetic rats. The levels and/or activities of other biochemical parameters were restored significantly compared to diabetic control rats due to treatment with fruit extract. Histology of liver and pancreas in STMe treated groups substantiated the cytoprotective action of the drug. Immunohistochemical observation of islets in extract treated diabetic rats showed apparent β-cells regeneration. These findings suggest that S. torvum fruit containing phenolic compounds has great potential as a natural source of antidiabetic and antioxidant drug. 相似文献
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Viswa Kalyan Kolli Indirani Kanakasabapathy Minnie Faith Hemalatha Ramamoorthy Bina Isaac Kasthuri Natarajan Premila Abraham 《Cancer chemotherapy and pharmacology》2013,71(5):1209-1218