全文获取类型
收费全文 | 5560篇 |
免费 | 284篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 71篇 |
儿科学 | 138篇 |
妇产科学 | 162篇 |
基础医学 | 702篇 |
口腔科学 | 146篇 |
临床医学 | 375篇 |
内科学 | 1439篇 |
皮肤病学 | 110篇 |
神经病学 | 514篇 |
特种医学 | 142篇 |
外科学 | 919篇 |
综合类 | 31篇 |
预防医学 | 321篇 |
眼科学 | 82篇 |
药学 | 235篇 |
中国医学 | 15篇 |
肿瘤学 | 476篇 |
出版年
2023年 | 53篇 |
2022年 | 114篇 |
2021年 | 285篇 |
2020年 | 120篇 |
2019年 | 217篇 |
2018年 | 229篇 |
2017年 | 165篇 |
2016年 | 138篇 |
2015年 | 143篇 |
2014年 | 226篇 |
2013年 | 291篇 |
2012年 | 460篇 |
2011年 | 521篇 |
2010年 | 262篇 |
2009年 | 239篇 |
2008年 | 357篇 |
2007年 | 361篇 |
2006年 | 345篇 |
2005年 | 327篇 |
2004年 | 256篇 |
2003年 | 239篇 |
2002年 | 208篇 |
2001年 | 28篇 |
2000年 | 28篇 |
1999年 | 40篇 |
1998年 | 42篇 |
1997年 | 28篇 |
1996年 | 15篇 |
1995年 | 20篇 |
1994年 | 14篇 |
1993年 | 18篇 |
1992年 | 13篇 |
1991年 | 11篇 |
1990年 | 7篇 |
1989年 | 7篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1981年 | 9篇 |
1980年 | 3篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1974年 | 2篇 |
1947年 | 1篇 |
1944年 | 1篇 |
1942年 | 1篇 |
1936年 | 1篇 |
1920年 | 1篇 |
排序方式: 共有5878条查询结果,搜索用时 15 毫秒
101.
102.
103.
104.
105.
106.
Cao Y Pahlberg J Sarria I Kamasawa N Sampath AP Martemyanov KA 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(20):7905-7910
The time course of signaling via heterotrimeric G proteins is controlled through their activation by G-protein coupled receptors and deactivation through the action of GTPase accelerating proteins (GAPs). Here we identify RGS7 and RGS11 as the key GAPs in the mGluR6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses. We showed using electroretinography and single cell recordings that the elimination of RGS7 did not influence dark-adapted light-evoked responses, but the concurrent elimination of RGS11 severely reduced their magnitude and dramatically slowed the onset of the response. In RGS7/RGS11 double-knockout mice, light-evoked responses in rod ON bipolar cells were only observed during persistent activation of rod photoreceptors that saturate rods. These observations are consistent with persistently high G-protein activity in rod ON bipolar cell dendrites caused by the absence of the dominant GAP, biasing TRPM1 channels to the closed state. 相似文献
107.
108.
Otano I Suarez L Dotor J Gonzalez-Aparicio M Crettaz J Olagüe C Vales A Riezu JI Larrea E Borras F Benito A Hernandez-Alcoceba R Menne S Prieto J González-Aseguinolaza G 《Hepatology (Baltimore, Md.)》2012,56(2):474-483
Regulatory T cells (Treg) play a critical role in the modulation of immune responses to viral antigens in chronic viral hepatitis. Woodchucks (Marmota monax) infected with the woodchuck hepatitis virus (WHV) represent the best animal model for chronic hepatitis B virus (HBV) infection. Examination of intrahepatic and peripheral Treg in uninfected and WHV chronically infected woodchucks showed a significant increase of intrahepatic Treg numbers in chronically infected animals, whereas no differences were found in peripheral blood. In agreement with these data, higher expression levels of Forkhead box P3 (Foxp3), interleukin (IL)-10, transforming growth factor beta (TGF-β) were detected in the liver of chronic WHV carriers in comparison to uninfected animals. Furthermore, treatment of WHV-infected animals with an adenovirus encoding IL-12 failed to reduce viral load, a finding that was associated with lymphocyte unresponsiveness to IL-12 stimulation in vitro. We observed that TGF-β and Treg play a major role in the lack of lymphocyte response to IL-12 stimulation, as TGF-β inhibition and Treg depletion allowed recovery of T-cell responsiveness to this cytokine. Based on these results, woodchucks were treated with IL-12 in combination with a TGF-β inhibitory peptide or Treg depletion. However, no antiviral effect was achieved and, instead, an enhancement of the intrahepatic tolerogenic environment was observed. CONCLUSION: Our data show that TGF-β inhibition or Treg depletion had no added benefit over IL-12 therapy in chronic WHV infection. IL-12 immunostimulation induces a strong immunosuppressive reaction in the liver of chronic WHV carriers that counteracts the antiviral effect of the treatment. 相似文献
109.
110.