全文获取类型
收费全文 | 3044篇 |
免费 | 314篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 180篇 |
妇产科学 | 62篇 |
基础医学 | 407篇 |
口腔科学 | 102篇 |
临床医学 | 273篇 |
内科学 | 497篇 |
皮肤病学 | 22篇 |
神经病学 | 174篇 |
特种医学 | 123篇 |
外科学 | 403篇 |
综合类 | 57篇 |
一般理论 | 4篇 |
预防医学 | 462篇 |
眼科学 | 102篇 |
药学 | 198篇 |
中国医学 | 1篇 |
肿瘤学 | 233篇 |
出版年
2021年 | 30篇 |
2019年 | 34篇 |
2018年 | 31篇 |
2017年 | 32篇 |
2015年 | 28篇 |
2014年 | 56篇 |
2013年 | 92篇 |
2012年 | 91篇 |
2011年 | 112篇 |
2010年 | 61篇 |
2009年 | 47篇 |
2008年 | 111篇 |
2007年 | 118篇 |
2006年 | 124篇 |
2005年 | 117篇 |
2004年 | 140篇 |
2003年 | 136篇 |
2002年 | 119篇 |
2001年 | 120篇 |
2000年 | 108篇 |
1999年 | 85篇 |
1998年 | 38篇 |
1997年 | 35篇 |
1996年 | 43篇 |
1995年 | 39篇 |
1994年 | 35篇 |
1993年 | 32篇 |
1992年 | 65篇 |
1991年 | 66篇 |
1990年 | 81篇 |
1989年 | 76篇 |
1988年 | 75篇 |
1987年 | 54篇 |
1986年 | 62篇 |
1985年 | 69篇 |
1984年 | 61篇 |
1983年 | 58篇 |
1982年 | 32篇 |
1981年 | 27篇 |
1980年 | 33篇 |
1979年 | 58篇 |
1978年 | 55篇 |
1977年 | 33篇 |
1976年 | 36篇 |
1974年 | 42篇 |
1973年 | 26篇 |
1972年 | 31篇 |
1970年 | 36篇 |
1969年 | 28篇 |
1967年 | 25篇 |
排序方式: 共有3359条查询结果,搜索用时 31 毫秒
81.
82.
83.
84.
85.
Fiachra E. Rowan Matthew J. Donaldson Jurek R. Pietrzak Fares S. Haddad 《Current reviews in musculoskeletal medicine》2018,11(3):370-379
Purpose of Review
In an era of increasing numbers of hip and knee replacements, strategies to manage prosthetic joint infection (PJI) that are effective at infection control with good patient-reported outcomes and cost containment for health systems are needed. Interest in single-stage exchange for PJI is rising and we assess evidence from the last 5 years related to this treatment strategy.Recent Findings
Only five series for total knee replacement and ten series for total hip replacement have been reported in the last five years. More review articles and opinion pieces have been written. Reinfection rates in these recent studies range from 0 to 65%, but a meta-analysis and systematic review of all studies showed a reinfection rate of 7.6% (95% CI 3.4–13.1) and 8.8% (95% CI 7.2–10.6) for single-stage and two-stage revisions respectively. There is emerging evidence to support single-stage revision in the setting of significant bony deficiency and atypical PJIs such as fungal infections.Summary
Prospective randomised studies are recruiting and are necessary to guide the direction of single-stage revision selection criteria. The onus of surgical excellence in mechanical removal of implants, necrotic tissue, and biofilms lies with the arthroplasty surgeon and must remain the cornerstone of treatment. Single-stage revision may be considered the first-line treatment for all PJIs unless the organism is unknown, the patient is systemically septic, or there is a poor tissue envelope.86.
Mbita Gaspar Komba Albert N. Casalini Caterina Bazant Eva Curran Kelly Christensen Alice Nyato Daniel Kim Young-Mi Reed Jason Makyao Neema Kategile Upendo Conserve Donaldson F. Faini Diana van Roosmalen Jos van den Akker Thomas 《AIDS and behavior》2022,26(10):3185-3198
AIDS and Behavior - The World Health Organization identified men as an essential group to target with HIV testing and treatment strategies;: men who have sex with men (MSM) and male clients of... 相似文献
87.
Composite graft replacement of the ascending aorta and aortic valve was performed in 71 patients over an 8-year period. Degenerative lesions of the aortic root in Marfan's syndrome (annuloaortic ectasia) was the indication for operation in 51 cases. Other causes of aortic root dilatation and aortic valve disease were present in the remaining 20 patients. Overall hospital mortality was 8%. Reoperation was required in 6 of the 65 hospital survivors. Follow-up has ranged from 1 to 9 years (average 41/2 years). Four year actuarial survival was 77%. Composite graft replacement eliminates paraprosthetic leakage and the risk of aneurysm formation of the sinuses of Valsalva; postoperative hemorrhage is also reduced. It appears to be the method of choice for the aortic root complications of the Marfan's syndrome. 相似文献
88.
BACKGROUND/AIMS: Recent reports of an association between human leucocyte antigens (HLA) and persistence of hepatitis B virus infection, and the familial clustering of hepatocellular carcinoma raise the question of genetic susceptibility. Previous studies have been limited to serological phenotyping of HLA B and DR antigens. The aim of this study was to use molecular genotyping to investigate HLA class II as a risk factor for the development of hepatocellular carcinoma in Hong Kong Chinese. METHODS: We determined HLA DRB1, DQA1, DQB1 and DPB1 alleles in 123 hepatitis B surface antigen positive patients (84 with hepatocellular carcinoma and 39 without) and 124 matched controls. RESULTS: The alleles DRB1*1501 (36% of HCC patients versus 19% of controls, odds ratio=2.44), DQA1*0102 (42% versus 26%, odds ratio=2.07), and DPB1*0501 (80% versus 63%, odds ratio=2.35) were significantly more common in patients with hepatocellular carcinoma, and DQA1*03 (36% versus 56%, odds ratio=0.53), DQB1*0302 (4.% versus 13%, odds ratio=0.25) and DPB1*0201 (14% versus 29%, odds ratio=0.4) were found at significantly lower frequencies. CONCLUSIONS: Although none of these associations was significant after correction for multiple testing, this report suggests that further investigations are warranted. 相似文献
89.
Pregnancy in chronic active hepatitis with cirrhosis 总被引:1,自引:0,他引:1
M G Lee B Hanchard E K Donaldson C Charles J S Hall 《The Journal of tropical medicine and hygiene》1987,90(5):245-248
Pregnancy in chronic active hepatitis and cirrhosis is rare. There is an appreciable perinatal mortality and the effect of pregnancy on the underlying liver disease remains uncertain. Two patients with autoimmune chronic active hepatitis with cirrhosis who became pregnant during an active stage of their disease while on therapy are described. Both had an uneventful pregnancy with successful deliveries. One of the patients had two other pregnancies but the pregnancy had to be terminated because of clinical deterioration. With close supervision patients with chronic active hepatitis and cirrhosis may have successful pregnancies. 相似文献
90.
Association of tumor necrosis factor polymorphism with primary sclerosing cholangitis 总被引:5,自引:0,他引:5
BACKGROUND/AIMS: Primary sclerosing cholangitis is associated with the HLA haplotypes A1-B8-DRB3*0101-DRB1*0301-DQA1*0501-DQB1*0201 and DRB3*0101-DRB1*1301-DQA1*0103-DQB1* 0603. However, the interpretation of these genetic associations is controversial. One explanation may be that HLA-encoded susceptibility is due to other genes carried on these haplotypes such as the HLA class III tumor necrosis factor genes. The aim of the study was to investigate tumor necrosis factor genetics in a large series of well-defined patients. METHODS: One hundred and ten HLA genotyped patients and 126 control subjects were studied by polymerase chain reaction genotyping for 3 different tumor necrosis factor gene polymorphisms: -308, -238 and an Ncol restriction fragment length polymorphism in the lymphotoxin alpha gene. RESULTS: Overall, 58% of patients had the TNF2 allele, compared with 29% of controls, p(c) = 0.0001. No association was found with either of the other tumor necrosis factor polymorphisms examined. TNF2 was significantly increased in the presence of B8 and DRB3*0101 only, and was independent of DRB1*0301 (p(c)<0.04). The associations with B8 and TNF2 were stronger than the associations with any of the HLA class II alleles examined. CONCLUSION: HLA-encoded genetic susceptibility to primary sclerosing cholangitis may be determined by polymorphism within the HLA class III region, in particular with the TNF2 allele. 相似文献