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Changhoon Park Hwi Won Seo Kiwon Han Chanhee Chae 《Clinical and Vaccine Immunology : CVI》2014,21(3):399-406
Under Korean field conditions, coinfection with porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) is most commonly observed in porcine respiratory disease complex (PRDC). Despite the wide use of PCV2 vaccination, PRDC remains a serious respiratory problem. Thus, the objective of this study was to determine and compare the efficacy of 4 one-dose PCV2 vaccines on 3-week-old pigs with an experimental PCV2-PRRSV challenge at 17 weeks postvaccination. Regardless of which commercial PCV2 vaccine was used, the vaccination of piglets at 3 weeks of age was efficacious against cochallenge of PCV2 and PRRSV, on the basis of growth performance and PCV2-associated lesions. However, the inactivated chimeric PCV1-2 and the PCV2 vaccines induced higher PCV2-specific neutralizing antibody (NA) titers and PCV2-specific gamma interferon-secreting cells and lower PCV2 viremia levels than the two PCV2 subunit vaccines. The vaccination of piglets against PCV2 at 3 weeks of age was effective in reducing PCV2 viremia and PCV2-associated lesions during the finishing period, which is an age at which pigs are frequently affected by PRDC caused by coinfection with PCV2 and PRRSV under Korean field conditions. 相似文献
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Novel nonsense GNAS mutation in a 14‐month‐old boy with plate‐like osteoma cutis and medulloblastoma
Kyu Young Seo Moon Kyu Kim Kyu Young Chae Se Hoon Kim Chang‐Seok Ki Moon Soo Yoon Dong Hyun Kim 《The Journal of dermatology》2014,41(4):319-321
Plate‐like osteoma cutis (PLOC) is a dermatological disorder characterized by superficial ossification and rarely occurs without any underlying tissue abnormalities or pre‐existing calcification. The hereditary form of PLOC is mainly due to inactivating mutation in the GNAS gene. Inactivating mutation of the GNAS gene is associated with several diseases, which commonly manifest heterotopic ossification and hormonal resistance; however, the development of malignant neoplasm has never been reported. Herein, we report a case of a patient with a novel nonsense mutation in the GNAS gene, who presented with concurrent PLOC and medulloblastoma. 相似文献
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Byung Woog Kang Jong Gwang Kim Yee Soo Chae Han Ik Bae Ohkyoung Kwon Ho Young Chung Wansik Yu Hong Suk Song Yu Na Kang Seung Wan Ryu Kyung Hee Lee Young Kyung Bae Joon Hyuk Choi Se Won Kim Hun‐Mo Ryoo Chang‐Ho Cho Hyun‐Dong Chae Kyun Woo Park Mi Jin Gu Byung‐Jo Bae 《Asia-Pacific Journal of Clinical Oncology》2014,10(2):e40-e45
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Emily S. Ihara David H. Chae Janet R. Cummings Sunmin Lee 《Administration and policy in mental health》2014,41(4):543-551
This study uses data from the National Latino and Asian American Study to investigate correlates of mental health service use among Asian Americans with mental health needs. Our study contributes to the extant literature by: (1) differentiating between mental health service use types; and (2) examining a broader swatch of Asian Americans with mental health needs, ranging from mild to severe cases. Multinomial logistic regression analyses revealed heterogeneity in service use patterns by ethnicity, age, marital status, English proficiency, and generation status. Unmet mental health needs continue to be a problem despite treatments that could improve the quality of life of Asian Americans. Our study provides a more nuanced understanding of mental health service utilization patterns in this understudied population. 相似文献
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