全文获取类型
收费全文 | 79106篇 |
免费 | 6003篇 |
国内免费 | 255篇 |
专业分类
耳鼻咽喉 | 907篇 |
儿科学 | 2043篇 |
妇产科学 | 1083篇 |
基础医学 | 10732篇 |
口腔科学 | 843篇 |
临床医学 | 8380篇 |
内科学 | 16970篇 |
皮肤病学 | 888篇 |
神经病学 | 7730篇 |
特种医学 | 3056篇 |
外科学 | 12797篇 |
综合类 | 884篇 |
一般理论 | 91篇 |
预防医学 | 5923篇 |
眼科学 | 1960篇 |
药学 | 5375篇 |
中国医学 | 94篇 |
肿瘤学 | 5608篇 |
出版年
2023年 | 607篇 |
2022年 | 877篇 |
2021年 | 2411篇 |
2020年 | 1358篇 |
2019年 | 2206篇 |
2018年 | 2527篇 |
2017年 | 1801篇 |
2016年 | 1894篇 |
2015年 | 2214篇 |
2014年 | 3209篇 |
2013年 | 4060篇 |
2012年 | 6509篇 |
2011年 | 6750篇 |
2010年 | 3690篇 |
2009年 | 3234篇 |
2008年 | 5391篇 |
2007年 | 5589篇 |
2006年 | 5177篇 |
2005年 | 5135篇 |
2004年 | 4635篇 |
2003年 | 4247篇 |
2002年 | 3851篇 |
2001年 | 594篇 |
2000年 | 395篇 |
1999年 | 565篇 |
1998年 | 786篇 |
1997年 | 588篇 |
1996年 | 478篇 |
1995年 | 425篇 |
1994年 | 399篇 |
1993年 | 395篇 |
1992年 | 252篇 |
1991年 | 197篇 |
1990年 | 178篇 |
1989年 | 162篇 |
1988年 | 156篇 |
1987年 | 130篇 |
1986年 | 133篇 |
1985年 | 144篇 |
1984年 | 181篇 |
1983年 | 150篇 |
1982年 | 236篇 |
1981年 | 233篇 |
1980年 | 164篇 |
1979年 | 94篇 |
1978年 | 114篇 |
1977年 | 99篇 |
1976年 | 69篇 |
1975年 | 59篇 |
1974年 | 48篇 |
排序方式: 共有10000条查询结果,搜索用时 406 毫秒
951.
952.
953.
954.
955.
956.
957.
Marcel Best Andrew N. Gifford Sung Won Kim Ben Babst Markus Piel Frank Rösch Joanna S. Fowler 《Journal of labelled compounds & radiopharmaceuticals》2012,55(1):39-43
A recent report that the aliphatic dicarboxylic acid, azelaic acid (1,9‐nonanedioic acid) but not related acids, suberic acid (1,8‐octanedioic acid) or sebacic (1,10‐decanedioic acid) acid induces systemic acquired resistance to invading pathogens in plants stimulated the development of a rapid method for labeling these dicarboxylic acids with 11C and 14C for in vivo mechanistic studies in whole plants. 11C‐labeling was performed by reaction of ammonium [11C]cyanide with the corresponding bromonitrile precursor followed by hydrolysis with aqueous sodium hydroxide solution. Total synthesis time was 60 min. Median decay‐corrected radiochemical yield for [11C]azelaic acid was 40% relative to trapped [11C]cyanide, and specific activity was 15 GBq/µmol. Yields for [11C]suberic and sebacic acids were similar. The 14C‐labeled version of azelaic acid was prepared from potassium [14C]cyanide in 45% overall radiochemical yield. Radiolabeling procedures were verified using 13C‐labeling coupled with 13C‐NMR and liquid chromatography–mass spectrometry analysis. The 11C and 14C‐labeled azelaic acid and related dicarboxylic acids are expected to be of value in understanding the mode‐of‐action, transport, and fate of this putative signaling molecule in plants. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
958.
959.
Andrew Timberlake Kathy Harry Alexander Kazberouk Simon Schimmack Ben Lawrence Roswitha Pfragner Irvin M. Modlin 《Cancer science》2013,104(7):844-855
Platelet‐derived serotonin (5‐HT) is involved in liver regeneration. The liver is also the metastatic site for malignant enterochromaffin (EC) cell “carcinoid” (neuroendocrine) neoplasms, the principal cellular source of 5‐HT. We hypothesized that 5‐HT produced by metastatic EC cells played a role in the hepatic tumor‐microenvironment principally via 5‐HT7 receptor‐mediated activation of hepatocyte IGF‐1 synthesis and secretion. Using isolated rat hepatocytes, we evaluated 5‐HT7 receptor expression (using PCR, sequencing and western blot). ELISA, cell transfection and western blots delineated 5‐HT‐mediated signaling pathways (pCREB, AKT and ERK). IGF‐1 synthesis/secretion was evaluated using QPCR and ELISA. IGF‐1 was tested on small intestinal neuroendocrine neoplasm proliferation, while IGF‐1 production and 5‐HT7 expression were examined in an in vivo SCID metastasis model. Our results demonstrated evidence for a functional 5‐HT7 receptor. 5‐HT activated cAMP/PKA activity, pCREB (130–205%, P < 0.05) and pERK/pAKT (1.2–1.75, P < 0.05). Signaling was reversed by the 5‐HT7 receptor antagonist SB269970. IGF‐1 significantly stimulated proliferation of two small intestinal neuroendocrine neoplasm cell lines (EC50: 7–70 pg/mL) and could be reversed by the small molecule inhibitor BMS‐754807. IGF‐1 and 5‐HT were elevated (40–300×) in peri‐tumoral hepatic tissue in nude mice, while 5‐HT7 was increased fourfold compared to sham‐operated animals. We conclude that hepatocytes express a cAMP‐coupled 5‐HT7 receptor, which, at elevated 5‐HT concentrations that occur in liver metastases, signals via CREB/AKT and is linked to IGF‐1 synthesis and secretion. Because IGF‐1 regulates NEN proliferation, identification of a role for 5‐HT7 in the hepatic metastatic tumor microenvironment suggests the potential for novel therapeutic strategies for amine‐producing mid‐gut tumors. 相似文献
960.