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991.
目的:探讨平原世居人群进入中度海拔(西宁地区,海拔高度2 260m)地区发生急性脑梗死(acute cerebral ischem,ACI)患者血浆同型半胱氨酸、血脂、血糖及血尿酸的变化.方法:对世居中度海拔地区99例ACI患者与73例进入中度海拔地区的世居平原人发生ACI患者,以及64例进入中度海拔地区的世居平原人未发生ACI人群的血浆同型半胱氨酸、血脂、血糖、血尿酸含量行测定、分析.结果:三组血糖(Glu)、血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、载脂蛋白A(Apo-A)、载脂蛋白B(Apo-B)含量均无显著性差异(P>0.05),而吸烟史、血浆同型半胱氨酸(Hcy)、高密度脂蛋白(HDL-C)、血尿酸(UA)含量有显著性差异(P<0.001或P<O.01).结论:Hcy、HDL-C的水平变化、吸烟史与世居平原人群进入中度海拔地区发生急性脑梗死密切相关,而HDL-C水平升高具有保护作用. 相似文献
992.
Zheng X Hong W Tang Y Ying T Wu Z Shang M Feng B Zhang W Hua X Zhong J Li S 《Acta neurochirurgica》2012,154(5):799-805
Background
Surgeons often rely on intraoperative electrophysiological monitoring to determine whether decompression is sufficient during microvascular decompression surgery for hemifacial spasms. A new monitoring method is needed when an abnormal muscle response is occasionally not available or is unreliable. This study was an observational clinical trial exploring a new waveform recorded from the facial muscles while the offending artery wall was electrically stimulated.Methods
Thirty-two patients with typical hemifacial spasm and 12 with trigeminal neuralgia as a control were included. The facial muscle response was recorded during microvascular decompression surgery while the offending artery wall was stimulated (2?mA?×?0.2?ms). The latency, amplitude, and effective refractory period were analyzed.Results
A waveform was recorded from the facial muscles of patients with hemifacial spasm when the offending artery wall was stimulated and was named the “Z-L response.” The latency was 7.3?±?0.8?ms, the amplitude was 0.08?±?0.02?mV, and the effective refractory period was 3.5–4?ms. The Z-L response disappeared immediately after microvascular decompression. No waveform was recorded from the facial muscles of patients with trigeminal neuralgia while the anterior inferior cerebellar artery, which adheres to the facial nerve, was stimulated (2?mA?×?0.2?ms).Conclusion
We found a new waveform for intraoperative monitoring of hemifacial spasm. The Z-L response was useful when the abnormal muscle response was absent before decompression or persisted after all vascular compressions were properly treated. Particularly, the Z-L response may help neurosurgeons determine the real culprit when multiple offending vessels exist. 相似文献993.
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995.
Tengfei Zheng Jing Zhao Yushu Wang Wennan Liu Zhihao Wang Yuanyuan Shang Wei Zhang Yun Zhang Ming Zhong 《Clinical biochemistry》2014
Objectives
The impacts of marine-derived n − 3 polyunsaturated fatty acids (n − 3 PUFAs) on cardiovascular risk are not well known. We conducted this meta-analysis to determine the effects of n − 3 PUFAs on cardiovascular outcomes and cardiovascular risk markers in patients with impaired glucose metabolism (IGM).Design and methods
We searched PUBMED, EMBASE, The Cochrane Library and reference lists of relevant papers for high quality randomized controlled trials comparing dietary intake of n − 3 PUFAs with placebo in IGM patients. Data was extracted and quality assessed independently by two reviewers. Authors were contacted for missing information. Overall estimates were calculated using a random-effects model or a fixed-effects model, and the possibility of publication bias was examined using a funnel plot. Subgroup analyses were conducted to explore the association between the risk markers and study characteristics.Results
Our meta-analysis included 19 studies, 24,788 patients. Compared with placebo, n − 3 PUFAs had no statistically significant reduce effect on cardiovascular mortality, major cardiovascular events, all-cause mortality or composite endpoint of all-cause mortality or hospitalization for cardiovascular cause, however it can significantly reduce the level of triglycerides (weighted mean difference [WMD] − 0.25 mmol/L; 95% CI − 0.37 to − 0.13: p < 0.001; 12 trials, 13,921 patients).Conclusion
Marine-derived n − 3 polyunsaturated fatty acids have no protective effect on cardiovascular mortality, major cardiovascular events, all-cause mortality and composite endpoint of all-cause mortality or hospitalization for cardiovascular cause in IGM patients, but can reduce triglyceride level. 相似文献996.
Wenchao Zhang Mengxiong Tang Ming Zhong Zhihao Wang Yuanyuan Shang Huiping Gong Yun Zhang Wei Zhang 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2013,7(3):138-142
AimThe six-transmembrane protein of prostate 2 (STAMP2) has been demonstrated to play a potential role in the pathogenesis of metabolic syndrome (MetS). The present study was designed to investigate the association of STAMP2 gene polymorphisms with MetS in Han Chinese population.MethodsA case-control study enrolled 350 Han Chinese subjects in two groups: 182 MetS patients and 168 control subjects. The clinical and biochemical characteristics were determined. Three single nucleotide polymorphisms (SNPs), rs1981529, rs12386756 and rs10263111 in STAMP2 gene were genotyped. The association of STAMP2 gene polymorphisms with MetS was analyzed.ResultsSNPs rs1981529 and rs10263111 were found to be significantly associated with MetS phenotype in male population (P = 0.014 and 0.025). Moreover, SNP rs1981529 was found to be associated with high density lipoprotein-cholesterol in male cases and with body mass index in female cases (P = 0.014 and 0.049). SNP rs10263111 was found to be associated with both waist circumference and diastolic blood pressure in total cases (P = 0.044 and 0.033). Haplotype analysis yielded significant association of STAMP2 gene with MetS in total (global P = 0.0109) and male population (global P = 0.0004).ConclusionOur findings revealed that STAMP2 gene polymorphisms are likely to significantly contribute to the risk of MetS in male Han Chinese population. 相似文献
997.
Hongyu Wang Jinbo Liu Hongwei Zhao Xiaobao Fu Guangyun Shang Yingyan Zhou Xiaolan Yu Xujing Zhao Guang Wang Hongyan Shi 《Journal of the American Society of Hypertension》2013,7(6):426-431
Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. In the present study, we investigated the possible risk factors involving CAVI in hypertension and diabetes mellitus (DM) subjects. One thousand sixty-three subjects (M/F 533/530) from Shougang Corporation Examination Center were divided into four groups: healthy group (n = 639); hypertension group (n = 312); DM group (n = 58); and hypertension with DM group (n = 54). CAVI was measured by VS-1000 apparatus. Our results showed that CAVI was significantly higher in hypertension subjects with DM than in healthy and hypertension group, respectively (8.59 ± 1.08 vs 7.23 ± 1.10; 8.59 ± 1.08 vs 7.94 ± 1.33; both P < .05). CAVI was positively correlated with age, systolic blood pressure, diastolic blood pressure, pulse pressure, fasting plasma glucose, HbA1c, uric acid, total cholesterol, triglycerides in the entire group (r = 0.633, 0.280, 0.172, 0.269, 0.209, 0.254, 0.176, 0.129, 0.175; all P < .05, respectively). There was negatively correlation between CAVI and high-density lipoprotein cholesterol in the entire group (r = ?0.167; P < .05). Multivariate analysis showed that age, body mass index, HbA1c, and high-density lipoprotein cholesterol were independent associating factors of CAVI in all subjects (β = 0.699; P < .001, β = ?0.189; P = .001, β = 0.144; P = .015, β = ?0.136; P = .019, respectively). Our present study suggested that CAVI was significantly higher in hypertension subjects with DM compared with healthy and hypertension groups. 相似文献
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目的深入了解截瘫患者直接照顾者照护过程的真实体验及需求,为提高截瘫患者家庭的生活质量提供帮助。方法采用立意抽样法选择17名截瘫患者直接照顾者作为研究对象,进行深入访谈,采用Colaizzi分析法对资料进行分析、整理并提炼主题。结果截瘫患者直接照顾者的照护体验包括以下7个方面:极度震惊和无法接受;心存侥幸;持续的身心疲惫;羞耻感;经济负担过重;缺乏经验;渴望社区服务。结论截瘫患者直接照顾者的体验受疾病进程的影响,且其社会支持体系不够完善;医护人员及社会机构除了关心患者外,还应主动关心其直接照顾者,帮助他们解决照护过程中的需求和困难。 相似文献