全文获取类型
收费全文 | 819篇 |
免费 | 46篇 |
国内免费 | 59篇 |
专业分类
儿科学 | 44篇 |
妇产科学 | 7篇 |
基础医学 | 52篇 |
口腔科学 | 15篇 |
临床医学 | 137篇 |
内科学 | 239篇 |
皮肤病学 | 17篇 |
神经病学 | 17篇 |
特种医学 | 231篇 |
外科学 | 46篇 |
综合类 | 30篇 |
预防医学 | 26篇 |
眼科学 | 8篇 |
药学 | 33篇 |
中国医学 | 2篇 |
肿瘤学 | 20篇 |
出版年
2022年 | 3篇 |
2021年 | 9篇 |
2020年 | 3篇 |
2019年 | 3篇 |
2018年 | 12篇 |
2017年 | 3篇 |
2015年 | 13篇 |
2014年 | 13篇 |
2013年 | 24篇 |
2012年 | 10篇 |
2011年 | 10篇 |
2010年 | 20篇 |
2009年 | 21篇 |
2008年 | 11篇 |
2007年 | 46篇 |
2006年 | 7篇 |
2005年 | 14篇 |
2004年 | 13篇 |
2003年 | 9篇 |
2002年 | 7篇 |
2001年 | 9篇 |
2000年 | 8篇 |
1999年 | 12篇 |
1998年 | 51篇 |
1997年 | 35篇 |
1996年 | 59篇 |
1995年 | 46篇 |
1994年 | 41篇 |
1993年 | 49篇 |
1992年 | 9篇 |
1991年 | 11篇 |
1990年 | 20篇 |
1989年 | 28篇 |
1988年 | 35篇 |
1987年 | 36篇 |
1986年 | 28篇 |
1985年 | 32篇 |
1984年 | 16篇 |
1983年 | 12篇 |
1982年 | 14篇 |
1981年 | 24篇 |
1980年 | 20篇 |
1979年 | 8篇 |
1978年 | 14篇 |
1977年 | 18篇 |
1976年 | 8篇 |
1975年 | 12篇 |
1973年 | 2篇 |
1972年 | 3篇 |
1970年 | 5篇 |
排序方式: 共有924条查询结果,搜索用时 0 毫秒
51.
52.
53.
LeRoy AJ; Williams HJ Jr; Bender CE; Segura JW; Patterson DE; Benson RC 《Radiology》1985,155(1):83-85
Two patients had colonic perforation as a result of percutaneous nephrostomy placement followed by track dilatation and renal calculus removal. We present the technical aspects of nephrostomy placement and stone removal, as well as the clinical diagnosis and management of these cases. Both patients recovered well with conservative therapy and required no surgical intervention. This report reviews the anatomic considerations for percutaneous nephrostomy in patients undergoing renal stone removal. 相似文献
54.
Arterial hypertension is a major cause of morbidity and mortalitybecause of its association with coronary heart disease, cerebrovasculardisease and renal disease. The extent of target organ involvement(i.e. heart, brain and kidneys) determines outcome. North Americanstudies have shown that hypertension is a major contributorto 500 000 strokes (250 000 deaths) and 1 000 000 myocardialinfarctions (500 000 deaths) per annum. 相似文献
55.
Sze CI Kindt G Huffer WB Chang M Wang M Kleinschmidt-DeMasters BK 《Clinical neuropathology》2004,23(2):80-90
Synovial cysts occur throughout the body and are generally benign lesions with limited clinical consequences. Juxtafacet cysts of the spine, in contrast, often press on a nerve root as it exits in the foramen, causing radiculopathy. Synovial tissue that emanates from the facet joint but extends medially, is an additional important cause of spinal stenosis. Over the past 5 years, neurosurgeons at our institution have operated on a large number of patients with back pain, with removal of abnormal synovial tissues. Histological examination of these tissues distinguishes the different types of pathologic processes responsible for producing symptoms. Juxtafacet cysts may be either mucin-filled ganglion cysts devoid of cyst lining or true synovial cysts with watery content and lined by synovial cells. Ganglion cysts arise in degenerated ligament at the facet joint, and occasionally within synovial stroma. Synovial cysts arise within synovium and, unlike synovial cysts in the extremities, have a thick wall containing granulation tissue, numerous histiocytes and giant cells. This hyperplastic, irritated synovium of the spine, which we term "synovial excrescences", is voluminous and this reactive part overshadows the cystic portion of the lesion in most instances. Iron pigment deposition and inflammation are mild to absent, making synovial excrescences different from pigmented villonodular synovitis. Synovial excrescences of the spine are an important cause of spinal stenosis, predominantly in elderly patients. Surgical removal of excrescences protruding into the spinal canal provides prompt and durable relief of symptoms, usually without the need for extensive bony laminectomy or spinal fusion. Several patients in our study had both spinal ganglion cysts and synovial excrescences, suggesting common risk factors for both lesions. 相似文献
56.
Sze CI Huffer W Breeze R Escott E Kleinschmidt-DeMasters BK 《Clinical neuropathology》2003,22(1):41-46
Cholesterol granulomas (CGs) are tumor-like lesions seldom encountered by neuropathologists. CGs develop in reaction to localized hemorrhage, often occurring in bony sites with possible impaired drainage of blood and blood products. The most common bony location is the petrous apex, although orbital, frontal sinus, and maxillary sinus sites have been reported. We compare and contrast three recent cases seen at our institution that illustrate the spectrum of clinical, radiographic, and pathologic features that can be seen with these mass lesions. One case demonstrated the unique pathological features of Gamma-Gandy body formation, epithelioid histiocytes heavily encrusted with iron pigments, and extensive tophi. The latter most likely represented aggregates of calcium pyrophosphate crystals associated with extensive iron deposition. 相似文献
57.
Cefalu WT; Wagner JD; Bell-Farrow AD; Edwards IJ; Terry JG; Weindruch R; Kemnitz JW 《Toxicological sciences》1999,52(2):49-55
Caloric restriction (CR) has been observed to retard aging processes and
extend the maximum life span in rodents. In an effort to evaluate the
effect of this nutritional intervention on physiologic variables in higher
species, several nonhuman primate trials are ongoing. In particular, a
study evaluating the independent effect of CR on the extent of
atherosclerosis was initiated in 1993 in 32 adult cynomolgus monkeys.
Therefore, the trial was designed to achieve identical cholesterol intake
after animals were randomized to a control group or a calorie-restricted
group (30% reduction from baseline caloric intake). The animals were
routinely evaluated for glycated proteins, plasma insulin and glucose
levels, insulin sensitivity, and specific measures for abdominal fat
distribution by CT scans over a 4-year interval. The results from 4 years
of intervention demonstrate that CR improves cardiovascular risk factors
(such as visceral fat accumulation) and improves insulin sensitivity. In
contrast to other primate studies with normolipidemic animals, CR had no
independent effects on plasma lipid levels and composition in the presence
of equivalent amounts of dietary cholesterol intake. Preliminary analysis
of atherosclerotic lesion extent in the abdominal aorta has failed to
demonstrate differences between control animals and CR animals. Follow- up
studies are being conducted to determine the effect of CR on
atherosclerosis extent in coronary and carotid arteries.
相似文献
58.
59.
JV Leonard JW Seakins K Bartlett J Hyde J Wilson B Clayton 《Archives of disease in childhood》1981,56(1):53-59
The clinical course of 4 patients who had reduced activities of 3-methylcrotonyl CoA carboxylase (also called 3-methylcrotonylglycinuria) is described. Two children presented with a metabolic acidosis, one in the neonatal period and the other with episodes of acidosis that started in the second year of life. In the other 2 children neurological symptoms were prominent, one having infantile spasms and the other developmental regression with a skin rash and alopecia. Three of the children responded well to oral biotin and dietary protein restriction but the fourth, despite a biochemical response to biotin, has a severe neurological handicap. The clinical presentation of inborn errors of 3-methylcrotonyl CoA carboxylase is variable. Metabolic acidosis may not be conspicuous and instead neurological features may predominate. 相似文献
60.
The distinction between true and suspected poisoning in children has not been made clear in previous work on childhood poisoning. A study of suspected poisoning in children under 15 years of age in a defined population of North East Bristol from November 1970 to July 1973 carried out by the Health Education Council Medical Research Division included 53,000 child-years at risk. The number of suspected poisonings was 3-4/1000 population aged under 15 years per year, with a higher incidence in younger age groups. Detailed investigation of the circumstances of the accidents carried out by a multidisciplinary team showed that at least 65%, and possibly as many as 78% were poisoning scares and not true poisoning. The evidence used by the casualty doctor and by the parents to diagnose poisoning was explored, and in many cases was circumstantial. Children with fathers in nonmanual occupations were over-represented. This may reflect differences in patterns of utilization behaviour rather than true differences in incidence. 相似文献