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91.
Jeremy T. Hines Woo-Lam Jo Quanjun Cui Michael A. Mont Kyung-Hoi Koo Edward Y. Cheng Stuart B. Goodman Yong-Chan Ha Phillippe Hernigou Lynne C. Jones Shin-Yoon Kim Takashi Sakai Nobuhiko Sugano Takuaki Yamamoto Mel S. Lee Dewei Zhao Wolf Drescher Tae-Young Kim Young-Kyun Lee Byung-Ho Yoon Seung-Hoon Baek Wataru Ando Hong-Seok Kim Jung-Wee Park 《Journal of Korean medical science》2021,36(24)
Non-traumatic osteonecrosis of the femoral head (ONFH) usually affects adults younger than 50 years and frequently leads to femoral head collapse and subsequent arthritis of the hip. It is becoming more prevalent along with increasing use of corticosteroids for the adjuvant therapy of leukemia and other myelogenous diseases as well as management of organ transplantation. This review updated knowledge on the pathogenesis, classification criteria, staging system, and treatment of ONFH. 相似文献
92.
Halari R Sharma T Hines M Andrew C Simmons A Kumari V 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2006,169(1):1-14
To explicate the neural correlates of sex differences in visuospatial and verbal fluency tasks, we examined behavioural performance
and blood-oxygenation-level-dependent (BOLD) regional brain activity, using functional magnetic resonance imaging, during
a three-dimensional (3D) mental rotation task and a compressed sequence overt verbal fluency task in a group of healthy men
(n=9) and women (n=10; tested during the low-oestrogen phase of the menstrual cycle). Men outperformed women on the mental rotation task, and
women outperformed men on the verbal fluency task. For the mental rotation task, men and women activated areas in the right
superior parietal lobe and the bilateral middle occipital gyrus in association with the rotation condition. In addition, men
activated the left middle temporal gyrus and the right angular gyrus. For verbal fluency, men activated areas in the bilateral
superior frontal gyrus, right cingulate gyrus, left precentral gyrus, left medial frontal gyrus, left inferior frontal gyrus,
thalamus, left parahippocampal gyrus and bilateral lingual gyrus, and women activated areas in the bilateral inferior frontal
gyrus and left caudate. Despite observing task related activation in the hypothesised areas in men and women, no areas significantly
differentiated the two sexes. Our results demonstrate comparable brain activation in men and women in association with mental
rotation and verbal fluency function with differential performance, and provide support for sex differences in brain–behaviour
relationships. 相似文献
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Enhanced angiogenesis and perineural invasion are markers of poor prognosis in patients with pancreatic cancer. Systemic therapies
for pancreatic cancer have been largely ineffective, and thus improved, targeted therapies are needed. Single nucleotide polymorphisms
(SNP) are DNA sequence variations that result in vast diversity of disease susceptibility and response to disease. CXCR2 is
an important mediator of CXC chemokine-induced angiogenesis and is upregulated in pancreatic cancer. In a preclinical corneal
micropocket assay, treatment of pancreatic cancer cell lines that express CXCR2 with anti-CXCR2 antibody inhibited angiogenesis.
To date, there have not been any CXCR2 SNP associated with pancreatic cancer, but CXCR2 SNP has been postulated to be associated
with angiogenesis in systemic sclerosis. The receptor tyrosine kinase encoded by the RET gene and its ligand glial derived
neurotrophic factor (GDNF) are upregulated in pancreatic cancer. In vitro treatment of pancreatic cancer cell lines that express
RET with anti-RET antibody or RET siRNA-inhibited GDNF-induced invasiveness. G691S RET SNP has been previously shown to be
associated with enhanced pancreatic cancer invasiveness. We suggest that molecular profiling of each patient’s tumor for G691S
RET SNP, potentially CXCR2 SNP, and also other yet-to-be identified SNP associated with pancreatic cancer will allow for both
improved understanding of individual prognosis and allow for utilization of more personalized, targeted adjuvant therapies.
This work was presented at the Molecular Surgeon Symposium on Personalized Genomic Medicine and Surgery at the Baylor College
of Medicine, Houston, TX, USA, April 12, 2008. The symposium was supported by a grant from the National Institutes of Health
(R13 CA132572 to Changyi Chen). 相似文献
95.
Lukobo-Durrell M. Aladesanmi L. Suraratdecha C. Laube C. Grund J. Mohan D. Kabila M. Kaira F. Habel M. Hines J. Z. Mtonga H. Chituwo O. Conkling M. Chipimo P. J. Kachimba J. Toledo C. 《AIDS and behavior》2022,26(11):3597-3606
AIDS and Behavior - A well-documented barrier to voluntary medical male circumcision (VMMC) is financial loss due to the missed opportunity to work while undergoing and recovering from VMMC. We... 相似文献
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Elizabeth E. McNeill Nicole L. Hines Regina Phariss 《Journal of the Association for Vascular Access》2009,14(1):46-51
The objectives of this survey were to: 1) understand current peripheral IV stabilization practices within our hospital and 2) evaluate the use of a new closed IV catheter system with a built-in stabilization platform. All medical-surgical patients within an 851-bed acute care hospital with peripheral-short catheters were evaluated within a 3-day period for catheter securement, dwell time, and signs of complications. Additionally, catheter restart data were collected from a renal telemetry unit for 2 weeks. Catheter and dressing protocols were then standardized to a new catheter system with a built-in stabilization platform (Nexiva? Closed Catheter System) and an absorbent transparent dressing (SorbaView® 2000). After a 2-week trial of the new protocol, catheters were again evaluated for securement and restart data were again collected from the renal telemetry unit. Staff nurse (N = 42) opinions on the new catheter system and dressing combination were sought, as well as a vote on willingness to change to the new catheter system and dressing. Results demonstrate improvement in catheter stabilization (out to 96 hours of dwell-time), decreased restarts, a high clinical preference for the new catheter/dressing system, and a high willingness to convert to the new system. Results indicate that the new closed IV catheter system with a built-in stabilization platform and the transparent absorbent dressing evaluated in this survey may help to improve catheter securement and increase dwell-time. Research studies utilizing more rigorous randomized, controlled comparisons are warranted. 相似文献
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