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Nevo I Sagi-Assif O Meshel T Geminder H Goldberg-Bittman L Ben-Menachem S Shalmon B Goldberg I Ben-Baruch A Witz IP 《Immunology letters》2004,92(1-2):163-169
In previous studies, we demonstrated that human neuroblastoma cells are equipped with the machinery to direct their homing to bone marrow. These tumor cells express the CXCR4 receptor for the bone marrow stroma-derived chemokine CXCL12 (SDF-1) and secrete the CXCL12 ligand. The present study was undertaken to explore possible differences in gene-expression patterns between neuroblastoma variants that over-express CXCR4 (designated STH cells) and those which express very little of this receptor (STL cells). The results of the study clearly indicate that these variants show a differential gene-expression profile. They differ in expression of some integrins such as VLA2, VLA3 and VLA6, of neuroendocrine-markers such as CD56 and synaptophysin, in the expression of c-kit and in the secretion of certain cytokines and growth factors such as TNFalpha, SDF-1, VEGF, IL-8, GM-CSF and IP-10. We hypothesize that these differences are due to an autocrine SDF-1alpha-CXCR4 axis. 相似文献
104.
Possible direct cytoxicity effects of cyclophosphamide on cultured human follicles: an electron microscopy study 总被引:2,自引:0,他引:2
Raz A Fisch B Okon E Feldberg D Nitke S Raanani H Abir R 《Journal of assisted reproduction and genetics》2002,19(10):500-506
Purpose
: To evaluate the direct effect of cyclophosphamide on cultured human ovarian follicles.
Methods
: Human ovarian cortical slices from premenopausal women were incubated with medium containing cyclophosphamide (0.0005–0.5 mg/mL) for 2–48 h and assessed by transmission electron microscopy. Noncultured specimens and samples cultured without cyclophosphamide were used as controls.
Results
: There were significantly more damaged granulosa cell nuclei after incubation with 0.5 mg/mL cyclophosphamide for at least 4 h. There were also more changes in the basement membrane after incubation with cyclophosphamide at concentrations of 0.05 and 0.5 mg/mL.
Conclusions
: Although the cyclophosphamide dose that caused damage to the granulosa cell nuclei was above the pharmacological level, our results suggest that cyclophosphamide, and not only its active metabolite phospharamide mustard, might have a destructive effect on human follicles, as it remains in the circulation longer. This effect could be mediated by damage to the granulosa cells and perhaps the basement membrane. 相似文献
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Nudel Itay Pokhojaev Ariel Hausman Bryan S. Bitterman Yoli Shpack Nir May Hila Sarig Rachel 《International journal of legal medicine》2020,134(5):1853-1860
International Journal of Legal Medicine - Unlike bones, teeth are remarkably resilient and can withstand severe trauma, making age assessment based on the dentition essential for forensic analysis.... 相似文献
107.
Efrat Dagan Yoram Cohen Adi Mory Vardit Adir Zvi Borochowitz Hila Raanani Alina Kurolap Svetlana Melikhan-Revzin Dror Meirow Ruth Gershoni-Baruch 《European journal of human genetics : EJHG》2014,22(2):277-279
BRCA mutation carriers were reported to display a skewed distribution of FMR1 genotypes, predominantly within the low normal range (CGG repeat number <26). This observation led to the interpretation that BRCA1/2 mutations are embryo-lethal, unless rescued by ‘low FMR1 alleles''. We undertook to re-explore the distribution of FMR1 alleles subdivided into low, normal and high (<26, 26–34, and >34 CGG repeats, respectively) subgenotypes, on a cohort of 125 Ashkenazi women, carriers of a BRCA1/2 founder mutation. Ashkenazi healthy females (n=368), tested in the frame of the Israeli screening population program, served as controls. BRCA1/2 carriers and controls demonstrated a comparable and non-skewed FMR1 subgenotype distribution. Taken together, using a homogeneous ethnic group of Ashkenazi BRCA1/2 mutation carriers, we could not confirm the reported association between FMR1 low genotypes and BRCA1/2 mutations. The notion that BRCA1/2 mutations are embryo-lethal unless rescued by the low FMR1 subgenotypes is hereby refuted. 相似文献
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Eva Rietk?tter Annalen Bleckmann Michaela Bayerlová Kerstin Menck Han-Ning Chuang Britta Wenske Hila Schwartz Neta Erez Claudia Binder Uwe-Karsten Hanisch Tobias Pukrop 《Oncotarget》2015,6(17):15482-15493
The mononuclear phagocytic system is categorized in three major groups: monocyte-derived cells (MCs), dendritic cells and resident macrophages. During breast cancer progression the colony stimulating factor 1 (CSF-1) can reprogram MCs into tumor-promoting macrophages in the primary tumor. However, the effect of CSF-1 during colonization of the brain parenchyma is largely unknown.Thus, we analyzed the outcome of anti-CSF-1 treatment on the resident macrophage population of the brain, the microglia, in comparison to MCs, alone and in different in vitro co-culture models. Our results underline the addiction of MCs to CSF-1 while surprisingly, microglia were not affected. Furthermore, in contrast to the brain, the bone marrow did not express the alternative ligand, IL-34. Yet treatment with IL-34 and co-culture with carcinoma cells partially rescued the anti-CSF-1 effects on MCs. Further, MC-induced invasion was significantly reduced by anti-CSF-1 treatment while microglia-induced invasion was reduced to a lower extend. Moreover, analysis of lung and breast cancer brain metastasis revealed significant differences of CSF-1 and CSF-1R expression.Taken together, our findings demonstrate not only differences of anti-CSF-1 treatment on MCs and microglia but also in the CSF-1 receptor and ligand expression in brain and bone marrow as well as in brain metastasis. 相似文献
110.