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71.
Zhao Yu Gafita Andrei Vollnberg Bernd Tetteh Giles Haupt Fabian Afshar-Oromieh Ali Menze Bjoern Eiber Matthias Rominger Axel Shi Kuangyu 《European journal of nuclear medicine and molecular imaging》2020,47(3):603-613
European Journal of Nuclear Medicine and Molecular Imaging - This study proposes an automated prostate cancer (PC) lesion characterization method based on the deep neural network to determine tumor... 相似文献
72.
Cristina Thompson MBA BA RN RM Elizabeth Halcomb PhD Grad Cert ICNurs Grad Cert HE BN RN FACN Malcolm Masso PhD MPH MNA BSc RN 《Scandinavian journal of caring sciences》2023,37(3):611-627
Background
Social connection is a fundamental human need. Its absence can lead to loneliness and social isolation, adversely impacting health and well-being. Given their regular contact and trusted relationships with older people, practitioners delivering community-based primary care are well-positioned to address this issue. However, their contribution to addressing loneliness and social isolation is unclear.Aim
This integrative review explores the contribution of the primary care workforce to interventions aimed at reducing loneliness and social isolation in community-dwelling older people.Method
Using an integrative review method, Scopus, Web of Science, CINAHL and PubMed were searched for original research published between 2000 and 2022. Fourteen papers reporting 13 primary studies were appraised for methodological quality and included in the review. Data were extracted into a summary table and analysed using thematic analysis.Results
Included studies came from over six countries. Internationally, primary care services have diverse structures, funding and workforces influencing their response to loneliness and social isolation. All but one intervention was multi-component, with ten studies including a group-based activity and three providing primarily individual-level activities. Only six studies reported reductions in loneliness following the intervention. Three themes were identified: characteristics of interventions; implementation context, barriers and facilitators; and differing contributions of primary care practitioners in addressing loneliness and social isolation of older people.Conclusion
There is increasing demand and scope for primary care practitioners to assist lonely and socially isolated older people. It is important to understand how to equip and incentivise these practitioners to routinely identify, assess and respond to lonely and socially isolated older people despite varying implementation contexts. There is a need for further research that explores how the primary care team can be better utilised to deliver effective interventions that reduce the health impacts of loneliness and social isolation. 相似文献73.
Tyrone Gabriel D. Sundiam RN Julia Czarina A. Sy RN Daniel Joseph E. Berdida PhD RN RM Patricia Yssabel R. Talampas RN Hazel Abigail A. Suillan RN Eloisa Andrea V. Sumangil RN Angela Mariz E. Sunga RN Samantha Nicole T. Sy Juco RN Kyle Catherine Talastas RN 《Public health nursing (Boston, Mass.)》2023,40(3):382-393
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76.
E. Rosser RN DPhil MN RM Dip N Ed Dip RM PFHEA E. Buckner RN PhD CNE AE-C FNAP T. Avedissian RN MSN D.S.K. Cheung BN MSc PhD K. Eviza RN MSN T. B. Hafsteinsdóttir RN PhD M.Y. Hsu RN PhD MSc M. N. Kirshbaum RN BSc MSc PhD GDip Health Ed Dip Onc Dip Counselling Dip CBT FHEA C. Lai RN PhD Y.C. Ng PhD J. Ramsbotham RN PhD MN S. Waweru RN MSN FNP-BC 《International nursing review》2020,67(4):484-494
77.
Devendra Kumar Pandey Tabarak Malik Abhijit Dey Joginder Singh RM Banik 《African journal of traditional, complementary, and alternative medicines》2014,11(2):439-446
Background
Gloriosa superba produces an array of alkaloids including colchicine, a compound of interest in the treatment of various diseases. The tuber of Gloriosa superba is a rich source of colchicine which has shown anti-gout, anti-inflammatory, and anti-tumor activity. However, this promising compound remains expensive and Gloriosa superba is such a good source in global scale. Increase in yield of naturally occurring colchicine is an important area of investigation.Materials and Methods
The effects of inoculation by four arbuscular mycorrhizal (AM), fungi, Glomus mossae, Glomus fasciculatum, Gigaspora margarita and Gigaspora gilmorei either alone or supplemented with P-fertilizer, on colchicine concentration in Gloriosa superba were studied. The concentration of colchicine was determined by high-performance thin layer chromatography.Results
The four fungi significantly increased concentration of colchicine in the herb. Although there was significant increase in concentration of colchicine in non-mycorrhizal P-fertilized plants as compared to control, the extent of the increase was less compared to mycorrhizal plants grown with or without P-fertilization. This suggests that the increase in colchicine concentration may not be entirely attributed to enhanced P-nutrition and improved growth. Among the four AM fungi Glomus mossae was found to be best. The total colchicine content of plant (mg / plant) was significantly high in plants inoculated with Glomus mossae and 25 mg kg−1phosphorus fertilizer (348.9 mg /plant) while the control contain least colchicine (177.87 mg / plant).Conclusion
The study suggests a potential role of AM fungi in improving the concentration of colchicine in Gloriosa superba tuber. 相似文献78.
79.
Degradable molecularly imprinted polymers (MIPs) with affinity for S-propranolol were prepared by the copolymerization of methacrylic acid as functional monomer and a disulfide-containing cross-linker, bis(2-methacryloyloxyethyl)disulfide (DSDMA), using bulk polymerization or high dilution polymerization for nanogels synthesis. The specificity and the selectivity of DSDMA-based molecularly imprinted polymers toward S-propranolol were studied in batch binding experiments, and their binding properties were compared to a traditional ethylene glycol dimethacrylate (EDMA)-based MIP. Nanosized MIPs prepared with DSDMA as crosslinker could be degraded into lower molecular weight linear polymers by cleaving the disulfide bonds and thus reversing cross-linking using different reducing agents (NaBH4, DTT, GSH). Turbidity, viscosity, polymer size and IR-spectra were measured to study the polymer degradation. The loss of specific recognition and binding capacity of S-propranolol was also observed after MIP degradation. This phenomenon was applied to modulate the release properties of the MIP. In presence of GSH at its intracellular concentration, the S-propranolol release was higher, showing that these materials could potentially be applied as intracellular controlled drug delivery system.Degradable molecularly imprinted polymers were prepared using redox sensitive cross-linkers and applied as intracellular drug delivery system to address the biocompatibility and cytotoxicity issues encountered with these synthetic polymers. 相似文献
80.
Jonathan L. Temte Shari Barlow Maureen Goss Emily Temte Cristalyne Bell Cecilia He Caroline Hamer Amber Schemmel Bradley Maerz Lily Comp Mitchell Arnold Kimberly Breunig Sarah Clifford Erik Reisdorf Peter Shult Mary Wedig Thomas Haupt James Conway Ronald Gangnon Ashley Fowlkes Amra Uzicanin 《Influenza and other respiratory viruses》2022,16(2):340
BackgroundInfluenza viruses pose significant disease burdens through seasonal outbreaks and unpredictable pandemics. Existing surveillance programs rely heavily on reporting of medically attended influenza (MAI). Continuously monitoring cause‐specific school absenteeism may identify local acceleration of seasonal influenza activity. The Oregon Child Absenteeism Due to Respiratory Disease Study (ORCHARDS; Oregon, WI) implements daily school‐based monitoring of influenza‐like illness‐specific student absenteeism (a‐ILI) in kindergarten through Grade 12 schools and assesses this approach for early detection of accelerated influenza and other respiratory pathogen transmission in schools and surrounding communities.MethodsStarting in September 2014, ORCHARDS combines automated reporting of daily absenteeism within six schools and home visits to school children with acute respiratory infection (ARI). Demographic, epidemiological, and symptom data are collected along with respiratory specimens. Specimens are tested for influenza and other respiratory viruses. Household members can opt into a supplementary household transmission study. Community comparisons are possible using a pre‐existing and highly effective influenza surveillance program, based on MAI at five family medicine clinics in the same geographical area.ResultsOver the first 5 years, a‐ILI occurred on 6634 (0.20%) of 3,260,461 student school days. Viral pathogens were detected in 64.5% of 1728 children with ARI who received a home visit. Influenza was the most commonly detected virus, noted in 23.3% of ill students.ConclusionORCHARDS uses a community‐based design to detect influenza trends over multiple seasons and to evaluate the utility of absenteeism for early detection of accelerated influenza and other respiratory pathogen transmission in schools and surrounding communities. 相似文献