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Brain tissue and serum from mice intracerebrally injected with 1 microgram of staphylococcal alpha-toxin contained elevated amounts of a naturally occurring brain tissue component(s) called muscle-relaxing factor (MRF). MRF induced reversible, generalized, flaccid paralysis of mice after intracerebral but not intraperitoneal or intravenous administration. MRF (i) was soluble in Hanks balanced salt solution and in acidified (pH 2) Hanks balanced salt solution, in which it partitions into ethyl acetate, acetone, and methanol; (ii) was separated from some pigments by thin-layer chromatography on silica gel plates; (iii) did not comigrate with prostaglandin and leukotriene standards during high-pressure liquid chromatography with a mu Bondapak fatty acid column; and (iv) did not contain amino acids, exhibit absorption maxima at a wavelength range of 210 to 600 nm, or fluoresce when exposed to UV light. MRF has been detected in rabbit brain that has been stored frozen at -70 degrees C and has been enhanced in vitro in slices of both mouse and rabbit brain following incubation of the brain slices with staphylococcal alpha-toxin. Studies to identify the chemical nature of MRF and the mechanism by which, in mice, it induces reversible, flaccid paralysis of voluntary muscle are continuing. 相似文献
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S. Szmigielski, M. Blankenship, J. P. Robinson and S. Harshman. Injury of myelin sheaths in isolated rabbit vagus nerves by α-toxin of Staphylococcus aureus. Toxicon17, 363–371, 1979.—Dissected rabbit vagus nerves were incubated in vitro with 0·24-4 μg of purified staphylococcal α-toxin (17,000 H.U./mg protein) per ml. The release of 86Rb from prelabeled nerves and the electrical activity of nerves (action potential) were measured and correlated with morphological changes observed by electron microscopy. At a concentration of α-toxin of 2 μg/ml, 30% of incorporated 86Rb was released from the nerves after 30 min of incubation. The electrical activity was maintained over this time period and required an additional 30 min before failing completely. Concentrations of α-toxin below 2 μg/ml had no effect on either the release of 86Rb or the electrical activity even after 60 min of incubation of the nerves. In contrast, dramatic changes in the morphology of the myelin sheaths are readily demonstrated after 30 min of incubation and can easily be observed at 0·2 μg/ml, a level of α-toxin which has no effect on 86Rb release or electrical activity. Both non-myelinated nerve fibers and Schwann cell membranes appear to be more resistant to the action of α-toxin. We conclude that, of the parameters measured, disorganization of myelin sheaths is the first recognizable symptom of injury to peripheral nerves by staphylococcal α-toxin. 相似文献
107.
Renal localization of gallium-67 citrate 总被引:1,自引:0,他引:1
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