全文获取类型
收费全文 | 931933篇 |
免费 | 66166篇 |
国内免费 | 1342篇 |
专业分类
耳鼻咽喉 | 12957篇 |
儿科学 | 24358篇 |
妇产科学 | 23234篇 |
基础医学 | 132880篇 |
口腔科学 | 28246篇 |
临床医学 | 80537篇 |
内科学 | 183230篇 |
皮肤病学 | 19227篇 |
神经病学 | 72180篇 |
特种医学 | 36799篇 |
外国民族医学 | 79篇 |
外科学 | 152068篇 |
综合类 | 18043篇 |
现状与发展 | 1篇 |
一般理论 | 234篇 |
预防医学 | 61742篇 |
眼科学 | 21309篇 |
药学 | 72528篇 |
3篇 | |
中国医学 | 2162篇 |
肿瘤学 | 57624篇 |
出版年
2018年 | 8960篇 |
2017年 | 7027篇 |
2016年 | 7759篇 |
2015年 | 8857篇 |
2014年 | 11980篇 |
2013年 | 17494篇 |
2012年 | 24076篇 |
2011年 | 25028篇 |
2010年 | 14798篇 |
2009年 | 14263篇 |
2008年 | 24596篇 |
2007年 | 25687篇 |
2006年 | 26474篇 |
2005年 | 25420篇 |
2004年 | 24554篇 |
2003年 | 23599篇 |
2002年 | 23143篇 |
2001年 | 54727篇 |
2000年 | 56542篇 |
1999年 | 46947篇 |
1998年 | 10730篇 |
1997年 | 9464篇 |
1996年 | 9592篇 |
1995年 | 8927篇 |
1994年 | 8278篇 |
1993年 | 7595篇 |
1992年 | 35490篇 |
1991年 | 33911篇 |
1990年 | 32735篇 |
1989年 | 31870篇 |
1988年 | 28993篇 |
1987年 | 28249篇 |
1986年 | 26289篇 |
1985年 | 25147篇 |
1984年 | 17833篇 |
1983年 | 15141篇 |
1982年 | 7796篇 |
1981年 | 6771篇 |
1979年 | 15782篇 |
1978年 | 10600篇 |
1977年 | 9053篇 |
1976年 | 7871篇 |
1975年 | 8630篇 |
1974年 | 10466篇 |
1973年 | 9859篇 |
1972年 | 9357篇 |
1971年 | 8852篇 |
1970年 | 8426篇 |
1969年 | 7923篇 |
1968年 | 7200篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
981.
K Tanaka Y Miyake S Sasaki Y Ohya S Miyamoto I Matsunaga T Yoshida Y Hirota H Oda 《Magnesium research》2006,19(4):268-275
There have only been a few studies on the role of mineral intake in tooth loss. We investigated the association between mineral intake and the prevalence of tooth loss in Japan. We used the baseline data on 1002 pregnant women who were enrolled in the Osaka Maternal and Child Health Study between November 2001 and March 2003. Tooth loss was defined as the previous extraction of one or more teeth. Nutrient intake was assessed by a validated diet history questionnaire. Prevalence odds ratios and confidence intervals were estimated by applying a multiple logistic regression model. The adjusted odds ratio upon comparison of the highest quartile with the lowest quartile of magnesium intake was 0.64 (95% confidence interval, 0.42-0.99), showing a tendency for an inverse dose-response relationship (p for linear trend = 0.05). There were no associations between the level of consumption of calcium, phosphate, iron, zinc, or copper and tooth loss. The present findings suggest that intake of magnesium is related to reduced prevalence of tooth loss among young Japanese women. 相似文献
982.
983.
Extranodal lymphomas presenting as soft tissue sarcomas to a sarcoma service over a two-year period.
J K O'Neill V Devaraj D A T Silver P Sarsfield C A Stone 《Journal of plastic, reconstructive & aesthetic surgery》2007,60(6):646-654
Non-Hodgkin's lymphoma usually presents with lymphadenopathy at multiple sites but can also involve any part of the musculoskeletal system. Occasionally the presentation is with a soft tissue mass. The presentation of large, superficial lymphomatous masses is similar both clinically and radiologically to that of soft tissue sarcomas. The six cases of lymphoma presenting to the Exeter Sarcoma Service as suspected soft tissue sarcomas, over a two-year period (2002-2004), are presented. We describe the clinical and imaging characteristics of these tumours and their subsequent management. Our cases showed variability in presentation. Only one of the six cases presented with pain and one with tenderness. Four of the cases had no lymphadenopathy and the other two had lymphadenopathy restricted to one nodal basin. Overlying soft tissue swelling occurred in four cases and in distal limb swelling beyond the mass in one case. Radiologically, lymphomas are known to be likely to exhibit confluent lymphadenopathy that is rare in patients with soft tissue sarcoma. Confluent lymphadenopathy was demonstrated in only one case of this series of patients. It is thought that lymphomas infiltrate across anatomical fascial planes more readily than sarcomas and in four of our six cases this feature was present. Clinical history, examination and MRI are insufficient to differentiate between soft tissue sarcoma and lymphoma and the importance of obtaining a pathological diagnosis prior to surgery is clear. It is crucial to differentiate lymphoma from sarcoma in order to avoid unnecessary excisional procedures in lymphoma patients. 相似文献
984.
985.
986.
Donald B. Penzien PhD ; Frank Andrasik PhD ; Brian M. Freidenberg PhD ; Timothy T. Houle PhD ; Alvin E. Lake III PhD; Gay L. Lipchik PhD ; Kenneth A. Holroyd PhD ; Richard B. Lipton MD ; Douglas C. McCrory MD ; Justin M. Nash PhD ; Robert A. Nicholson PhD ; Scott W. Powers PhD ABPP ; Jeanetta C. Rains PhD ; David A. Wittrock PhD 《Headache》2005,45(S2):S110-S132
Guidelines for design of clinical trials evaluating behavioral headache treatments were developed to facilitate production of quality research evaluating behavioral therapies for management of primary headache disorders. These guidelines were produced by a Workgroup of headache researchers under auspices of the American Headache Society. The guidelines are complementary to and modeled after guidelines for pharmacological trials published by the International Headache Society, but they address methodologic considerations unique to behavioral and other nonpharmacological treatments. Explicit guidelines for evaluating behavioral headache therapies are needed as the optimal methodology for behavioral (and other nonpharmacologic) trials necessarily differs from the preferred methodology for drug trials. In addition, trials comparing and integrating drug and behavioral therapies present methodological challenges not addressed by guidelines for pharmacologic research. These guidelines address patient selection, trial design for behavioral treatments and for comparisons across multiple treatment modalities (eg, behavioral vs pharmacologic), evaluation of results, and research ethics. Although developed specifically for behavioral therapies, the guidelines may apply to the design of clinical trials evaluating many forms of nonpharmacologic therapies for headache. 相似文献
987.
Herlinde Dumez Gunther Guetens Gert De Boeck Martin S Highley Robert A A Maes Allan T van Oosterom Ernst A de Bruijn 《Clinical chemistry and laboratory medicine》2004,42(11):1219-1227
Therapeutic drug monitoring generally focuses on the plasma compartment only. Differentiation between the total plasma concentration and the free fraction (plasma water) has been described for a number of limited drugs. Besides the plasma compartment, blood has also a cellular fraction which has by far the largest theoretical surface and volume for drug transport. It is with anti-cancer drugs that major progress has been made in the study of partition between the largest cellular blood compartment, i.e., erythrocytes, and the plasma compartment. The aim of the present review is to detail the progress made in predicting what a drug does in the body, i.e., pharmacodynamics including toxicity and plasma and/or red blood cell concentration monitoring. Furthermore, techniques generally used in anti-cancer drug monitoring are highlighted. Data for complex Bayesian statistical approaches and population kinetics studies are beyond the scope of this review, since this is generally limited to the plasma compartment only. 相似文献
988.
Dr. S. Besier T.M. Bingold F. Walcher K. Engels B. Spellerberg V. Brade C. Brandt 《Der Chirurg》2007,78(12):1148-1151
Streptococcus agalactiae, known as a pathogen that causes meningitis and septicemia in neonates, emerges as an invasive organism in nonpregnant adults. This case report describes the fulminant course of a necrotizing fasciitis (NF) with streptococcal toxic shock-like syndrome (STSS) in a 76-year-old diabetic patient caused by S. agalactiae, serotype V. Chronic diseases and immunodeficiency are considered to be risk factors for the acquisition of group B streptococcal disease. Since early surgical treatment in conjunction with antimicrobial and intensive care therapy is critical for the outcome of patients with NF and/or STSS, clinicians should be aware of invasive S. agalactiae infections in adults with subcutaneous emphysema. 相似文献
989.
Mary Lou Galantino Michael Baime Maureen Maguire Philippe O Szapary John T Farrar 《Stress and health》2005,21(4):255-261
Work stress, burnout, and diminished empathy are prevalent issues for health‐care professionals. Mindfulness meditation (MM) is one commonly used strategy to manage stress. Measuring salivary cortisol allows for the assessment of serum cortisol level, a known stress level indicator. This study evaluated the association of subject‐reported stress symptoms and salivary cortisol in health‐care professionals, in an 8‐week MM program, with data collected prospectively at baseline and 8 weeks after program completion. Questionnaires [Profile of Mood States—Short Form (POMS‐SF), Maslach Burnout Inventory (MBI), and Interpersonal Reactivity Index (IRI)] measured mood, burnout and empathy. A paired t‐test between groups for pre/post‐salivary cortisol yielded no significant change. The POMS‐SF was most sensitive to change (mean increase 12.4; p = 0.020). Emotional exhaustion, measured in the MBI, was also affected by MM (mean decrease 4.54; p = 0.001). Changes in empathy may not have been captured due to either absence of effect of MM on empathy, subject number or scale sensitivity. Baseline and 8‐week correlations between salivary cortisol and survey results, and correlations between changes in these measures, were weak and not statistically significant. Nevertheless, psychometric results present a strong case for additional clinical trials of MM to reduce stress for health‐care professionals. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
990.