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131.
INVOLVEMENT OF NON-NMDA AND NMDA RECEPTORS IN GLUTAMATE-INDUCED PRESSOR OR DEPRESSOR RESPONSES OF THE PONS AND MEDULLA 总被引:1,自引:0,他引:1
SY Chen WC Wu CJ Tseng JS Kuo CY Chai 《Clinical and experimental pharmacology & physiology》1997,24(1):46-56
1. Fifty-five intact and six baroreceptor denervated and vagotomized cats of either sex were anaesthetized intraperito-neally with urethane (400 mg/kg) and a-chloralose (40 mg/kg). Responses of the systemic arterial pressure (SAP), mean SAP (MSAP) and sympathetic vertebral nerve (VNA) and renal nerve activities (RNA) were recorded. 2. In intact animals, monosodium L-glutamate (Glu, 0.1 mol/L, 50 nL) was microinjected into pressor areas of the locus coeruleus (LC), gigantocellular tegmental field (GTF), rostral ventrolateral medulla (RVLM) and dorsomedial medulla (DM), and the depressor areas of caudal ventrolateral medulla (CVLM). The induced actions were compared before and after microinjection of either glutamate antagonists, glutamate diethylester (GDEE, 0.5 mol/L, 50–100nL), a competitive AMPA receptor blocker, or 2-amino-5-phosphonovaleric acid (D-AP5, 0.025 mol/L, 50–100 nL), a competitive N-methyl-D-aspartate (NMDA) receptor blocker. GDEE completely blocked the increases of SAP and VNA elicited from all pressor areas. D-AP5 only partially blocked the pressor but slightly blocked VNA and RNA responses from LC, GTF and DM, particularly those from RVLM. Neither GDEE nor D-AP5 blocked the depressor responses of SAP and two nerve activities elicited from CVLM. 3. In baroreceptor denervated animals, NMDA (2 mmol/L, 50–100 nL) and AMPA (0.2 mmol/L, 50–100 nL) were micro-injected into the same pressor areas of GTF, RVLM and DM and the depressor area of CVLM responsive to Glu activation (0.1 mol/L, 30 nL). In RVLM, DM and CVLM, the results of either NMDA or AMPA were similar to those induced by Glu. However, in GTF, microinjection of either NMDA or AMPA did not induce similar responses to Glu. This suggests that the nature of GTF may differ from RVLM and DM. 4. The above results suggest that the Glu-induced pressor responses from LC, GTF, DM and especially RVLM, are primarily mediated through AMPA receptors. The Glu-induced depressor responses from CVLM may not be predominantly mediated by either AMPA or NMDA receptors. 5. In both baroreceptor-intact and -denervated cats stimulation of the pressor areas often produced an increase of VNA and a decrease of RNA, while in the depressor CVLM decreased both VNA and RNA. The VNA, but not RNA were positively correlated with the pressor responses, while both VNA and RNA were positively correlated with the depressor responses. This may suggest that neurons of the sympathetic vertebral and renal nerves are topographically organized in the brain. 相似文献
132.
目的 寻找一种有利于粉碎性髌骨骨折术中复位、固定和术后恢复的手术入路。方法 采用膝内侧改良切口结合NT-聚髌器(NT-pc)治疗粉碎性髌骨骨折38例,其中碎骨块呈3块者18例、4块者13例、5块者5例、6块者2例。结果 38例随访时间3个月—2年6个月,除1例因二次手术病程较长、1例术后缺乏锻炼致膝关节功能稍受影响外,其他患者膝关节活动均恢复正常,切口愈合好,按李纯志等疗效评定标准,优良率94.7%。结论 膝内侧改良切口具有充分显露髌骨、切口短、组织损伤小,有利于术中手指对骨块抚平复位和对关节面复位质量的检查及术后功能恢复;NT-pc符合张力带原理,对严重粉碎性髌骨骨折的骨折面具有持续的纵向及横向的应力作用,有复位及固定的双重作用。对于严重粉碎性髌骨骨折,采用内侧改良切口及NT-pc固定不失为一种较理想的方法。 相似文献
133.
莱姆病(Lymedisease)是最近十年来才被认识的一种蜱媒传染流行病,Lyme病的血清学诊断方法有间接荧光免疫法(IFA),酶免疫试验()EIA),免疫印迹法(WB),梅里埃生物公司(Biomerieux)推出VIDAS免疫诊断系统能够自动定性和半定量地检查Lyme病的抗伯氏包柔螺旋体抗(抗BB抗体)。本方法结合了酶和荧光免疫两种方法。硷性磷酸酶标记二抗的底物是4methylumbellife 相似文献
134.
以BDXL-Ⅱ型注意力分配测试仪对某汽车队177名驾驶员和139名非驾驶员进行了注意力分配检查,并计算每人注意力分配量Q值。结果表明,驾驶员组注意力分配及视、听觉反应速度有随年龄和驾车年数增长而下降的趋势,Q值及视、听觉反应测试得分与对照组相比差异有显著性。 相似文献
135.
Ninety cases of infertility and habitual abortion were analyzed by hysteroscopy between April 1983 and July 1990 in PUMC hospital. Abnormal changes of the uterine cavity were seen in 74.4%. The result of hysterosalpingography corresponded with that of hysteroscopy in 62.5%, and the result of B-ultrasound corresponded to that of hysteroscopy in 52.5%. The diagnosis of adhesion and polyps of the uterine cavity was made accurately by hysteroscopy, and both could be operated under hysteroscopy. After operative removal of the adhesion, an IUD should be put into the uterine cavity for 3 months. In 60 cases operations were performed during or after hysteroscopy. Of the 45 patients followed, 19 achieved pregnancy. Five patients achieved pregnancy after operative removal of the adhesion. It is concluded that hysteroscopy is more important than B-ultrasound and hysterosalpingography in the examination and treatment of infertility. 相似文献
136.
The purpose of this study is to discuss the effects of the Chinese medicine six-flavor Rehmannia Decoction with additives on preventing deafness induced by gentamicin (GM) in guinea pig by means of testing the thresholds of Preyer's reflex (PR) cochlear microphonic potential (CM), action potential of the auditory nerve (N1) and scanning electron microscope of inner ear (SEM). The results showed that the medicine is effective in reducing the ototoxic effect of GM on inner ear. 相似文献
137.
癌旁组织CD44vmRNA的表达对原发性肝癌术后复发的影响 总被引:4,自引:0,他引:4
研究原发性肝癌癌旁组织CD44vmRNA表达的意义。应用RT-PCR检测原发性肝癌癌旁组织CD44vmRNA的表达并结合术后近2年的随访结果进行综合分析。癌旁组织CD44vmRNA表达高于癌组织者的肿瘤包膜缺如、门静脉癌栓和瘤周卫星结节等与转移相 关的病理指标高于癌旁组织CD44vmRNA表达低于癌组织的病例,前者复发率亦高于后者。结论:癌旁组织CD44vmRNA的表达肝癌侵袭潜能以及预测其复发等 相似文献
138.
应用光化学诱导法建立免局灶性脑梗塞模型,为临床治疗人的脑梗塞疾病提供有效的实验研究手段。结果显示,模型制作成功率98%,梗塞灶面积为0.465±0.012 cm2,体积为0.268±0.009 cm3,梗塞灶呈典型的损伤、渗出和炎症反应病理过程。结果提示,光化学诱导法建立免局灶性脑梗塞模型方便、快速、稳定。 相似文献
139.
140.
Treatment of singultus following craniocerebral injury★
Intranasal cavity drip infusion versus intramuscular injection of aminazine 总被引:1,自引:0,他引:1
BACKGROUND: Craniocerebral injury always accompanies with singultus, while frequent singultus may cause increased intracranial pressure. Simultaneously, respiratory alkalosis and cerebral hypoxia induced by respiratory disorder may aggravate craniocerebral injury.
OBJECTIVE: To observe the therapeutic effects of intranasal cavity drip infusion of aminazine and intramuscular injection on singultus following craniocerebral injury.
DESIGN: Contrast observation.
SETTING: Department of Neurosurgery, Xi'an Aerospace General Hospital.
PARTICIPANTS: A total of 102 patients with singultus following craniocerebral injury were selected from the Department of Neurosurgery, Xi'an Aerospace General Hospital from June 2001 to June 2006. Patients with craniocerebral injury were diagnosed with CT examination and randomly divided into nasal cavity medication group (n =62) and intramuscular injection group (n =40). There were 44 males and 18 females in the nasal cavity medication group and their mean age was (33±4) years; while, there were 26 males and 14 females in the intramuscular injection group and their mean age was (29±4) years. All patients and their relatives provided the confirmed consent.
METHODS: Patients in the nasal cavity medication group were slowly dripped aminazine solution into bilateral nasal cavity with the dosage of 12.5 mg (0.5 mL). Patients who had no obvious effect or had mild improvement received the treatment once every 6 hours. The treatment was stopped if symptoms were also observed after the fifth medication. In addition, patients in the intramuscular injection group received intramuscular injection of 50 mg aminazine. Patients who had no obvious effect or had mild improvement received the treatment once every 6 hours. The treatment was changed if symptoms were also observed after the fifth medication.
MAIN OUTCOME MEASURES: Therapeutic effects of different medications in the two groups.
RESULTS: All 102 patients were involved in the final analysis. Effective rate in the nasal cavity medication group was higher than that in the intramuscular injection group, and there was significant difference (χ2= 11.882, P < 0.01). At 6 hours after onset of singultus, effective rate in the nasal cavity medication group was higher than that in the intramuscular injection group, and there was significant difference (χ2 =8.188, P < 0.01).
CONCLUSION: Therapeutic effects of intranasal cavity drip infusion of aminazine on singultus following craniocerebral injury are superior to those of intramuscular injection. 相似文献