全文获取类型
收费全文 | 1127篇 |
免费 | 139篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 28篇 |
妇产科学 | 12篇 |
基础医学 | 108篇 |
口腔科学 | 2篇 |
临床医学 | 85篇 |
内科学 | 310篇 |
皮肤病学 | 12篇 |
神经病学 | 226篇 |
特种医学 | 74篇 |
外科学 | 138篇 |
综合类 | 19篇 |
预防医学 | 116篇 |
眼科学 | 20篇 |
药学 | 77篇 |
肿瘤学 | 39篇 |
出版年
2023年 | 12篇 |
2021年 | 21篇 |
2020年 | 12篇 |
2019年 | 21篇 |
2018年 | 16篇 |
2017年 | 13篇 |
2016年 | 20篇 |
2015年 | 24篇 |
2014年 | 34篇 |
2013年 | 39篇 |
2012年 | 85篇 |
2011年 | 65篇 |
2010年 | 49篇 |
2009年 | 36篇 |
2008年 | 67篇 |
2007年 | 60篇 |
2006年 | 62篇 |
2005年 | 43篇 |
2004年 | 33篇 |
2003年 | 29篇 |
2002年 | 34篇 |
2001年 | 24篇 |
2000年 | 29篇 |
1999年 | 18篇 |
1998年 | 13篇 |
1997年 | 10篇 |
1995年 | 7篇 |
1992年 | 22篇 |
1991年 | 15篇 |
1990年 | 17篇 |
1989年 | 21篇 |
1988年 | 12篇 |
1987年 | 20篇 |
1986年 | 13篇 |
1985年 | 17篇 |
1984年 | 18篇 |
1983年 | 14篇 |
1982年 | 10篇 |
1981年 | 14篇 |
1979年 | 17篇 |
1978年 | 10篇 |
1976年 | 14篇 |
1974年 | 9篇 |
1973年 | 15篇 |
1972年 | 13篇 |
1970年 | 16篇 |
1969年 | 14篇 |
1968年 | 9篇 |
1967年 | 9篇 |
1966年 | 12篇 |
排序方式: 共有1267条查询结果,搜索用时 0 毫秒
101.
102.
The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients 总被引:4,自引:0,他引:4
Knake S Halgren E Shiraishi H Hara K Hamer HM Grant PE Carr VA Foxe D Camposano S Busa E Witzel T Hämäläinen MS Ahlfors SP Bromfield EB Black PM Bourgeois BF Cole AJ Cosgrove GR Dworetzky BA Madsen JR Larsson PG Schomer DL Thiele EA Dale AM Rosen BR Stufflebeam SM 《Epilepsy research》2006,69(1):80-86
OBJECTIVE: To evaluate the sensitivity of a simultaneous whole-head 306-channel magnetoencephalography (MEG)/70-electrode EEG recording to detect interictal epileptiform activity (IED) in a prospective, consecutive cohort of patients with medically refractory epilepsy that were considered candidates for epilepsy surgery. METHODS: Seventy patients were prospectively evaluated by simultaneously recorded MEG/EEG. All patients were surgical candidates or were considered for invasive EEG monitoring and had undergone an extensive presurgical evaluation at a tertiary epilepsy center. MEG and EEG raw traces were analysed individually by two independent reviewers. RESULTS: MEG data could not be evaluated due to excessive magnetic artefacts in three patients (4%). In the remaining 67 patients, the overall sensitivity to detect IED was 72% (48/67 patients) for MEG and 61% for EEG (41/67 patients) analysing the raw data. In 13% (9/67 patients), MEG-only IED were recorded, whereas in 3% (2/67 patients) EEG-only IED were recorded. The combined sensitivity was 75% (50/67 patients). CONCLUSION: Three hundred and six-channel MEG has a similarly high sensitivity to record IED as EEG and appears to be complementary. In one-third of the EEG-negative patients, MEG can be expected to record IED, especially in the case of lateral neocortical epilepsy and/or cortical dysplasia. 相似文献
103.
Jose?Enrique?MartinEmail author Nadia?Sadiq?Ali Fiona?Hamer 《Gynecological surgery》2005,2(4):301-303
We present a case of a mucinous borderline ovarian tumour in a 16-year-old patient. It was removed by ovarian cystectomy before histological confirmation of its borderline nature. 相似文献
104.
Mechanical prophylaxis of deep-vein thrombosis after total hip replacement a randomised clinical trial 总被引:3,自引:0,他引:3
Pitto RP Hamer H Heiss-Dunlop W Kuehle J 《The Journal of bone and joint surgery. British volume》2004,86(5):639-642
Routine prophylaxis for venous thromboembolic disease after total hip replacement (THR) is recommended. Pneumatic compression with foot pumps seems to provide an alternative to chemical agents. However, the overall number of patients investigated in randomised clinical trials has been too small to draw evidence-based conclusions. This randomised clinical trial was carried out to compare the effectiveness and safety of mechanical versus chemical prophylaxis of DVT in patients after THR. Inclusion criteria were osteoarthritis of the hip and age less than 80 years. Exclusion criteria included a history of thromboembolic disease, heart disease, and bleeding diatheses. There were 216 consecutive patients considered for inclusion in the trial who were randomised either for management with the A-V Impulse System foot pump. We excluded 16 patients who did not tolerate continuous use of the foot pump or with low-molecular-weight heparin (LMWH). Patients were monitored for DVT using serial duplex sonography at 3, 10 and 45 days after surgery. DVT was detected in three of 100 patients in the foot-pump group and with six of 100 patients in the LMWH group (p < 0.05). The mean post-operative drainage was 259 ml in the foot-pump group and 328 ml in the LMWH group (p < 0.05). Patients in the foot-pump group had less swelling of the thigh (10 mm compared with 15 mm; p < 0.05). One patient developed heparin-induced thrombocytopenia. This study confirms the effectiveness and safety of mechanical prophylaxis of DVT in THR. Some patients cannot tolerate the foot pump. 相似文献
105.
Stephen W Veitch Sharon C Findlay Bridget M Ingle Chris J Ibbotson Anne Barrington Andrew J Hamer Richard Eastell 《Journal of clinical densitometry》2004,7(2):209-217
The ability of 29 peripheral quantitative computed tomography (pQCT) software analysis modes at defining cortical from trabecular bone at three tibial metaphyseal regions was evaluated using five cadaveric tibiae. The accuracy of pQCT was determined by comparing the bone mineral content (BMC) with the ash weight. The precision of the pQCT scanner was calculated using repeated measurements. All the analysis modes had a good accuracy when measuring total bone area and a poor accuracy when measuring cortical bone area at the proximal 5% and distal 4% regions. For trabecular bone measured at all three regions and cortical bone area measured at the proximal 10% region, the Stratec peel mode 5 was the most accurate analysis mode. Highly significant correlations (r = 0.71-0.98) and a moderate accuracy error (coefficient of variation [CV] = 5-22%) was found between ash weight and BMC when using this mode. The precision of bone mineral density (BMD) measurements was good (total, CV = 2-5%; trabecular, CV = 2-5%; cortical, CV = 4-6%). pQCT is a moderately accurate, precise method of measuring trabecular and total BMD at the tibial metaphysis. The authors recommend caution when interpreting results for cortical BMD, as cortical area measurements at the metaphyseal region are less accurate and less precise. 相似文献
106.
NURTURE: Development and pilot testing of a novel parenting intervention for mothers with histories of an eating disorder 下载免费PDF全文
Cristin D. Runfola PhD Nancy L. Zucker PhD Ann Von Holle MS Suzanne Mazzeo PhD Eric A. Hodges PhD Eliana M. Perrin MD MPH Margaret E. Bentley PhD T. Frances Ulman PhD Elizabeth R. Hoffman MD PhD Sarah Forsberg PsyD Monica Ålgars PhD Stephanie Zerwas PhD Emily M. Pisetsky MA Colie Taico LCSW Rebecca A. Kuhns MD Robert M. Hamer PhD Cynthia M. Bulik PhD 《The International journal of eating disorders》2014,47(1):1-12
107.
108.
Gary O’Donovan David Stensel Mark Hamer Emmanuel Stamatakis 《European journal of epidemiology》2017,32(7):559-566
The objective of this study was to investigate associations between leisure-time physical activity, low high-density lipoprotein cholesterol (HDL-C) and mortality. Self-reported leisure-time physical activity, HDL-C concentration, and mortality were assessed in 37,059 adults in Health Survey for England and Scottish Health Survey. Meeting physical activity guidelines was defined as ≥150 min wk?1 of moderate-intensity activity, ≥75 min wk?1 of vigorous-intensity activity, or equivalent combinations. Low HDL-C was defined as <1.03 mmol L?1. Cox proportional hazard models were adjusted for age, sex, smoking, total cholesterol, systolic blood pressure, body mass index, longstanding illness, and socioeconomic status. There were 2250 deaths during 326,016 person-years of follow-up. Compared with those who met physical activity guidelines and whose HDL-C was normal (reference group), all-cause mortality risk was not elevated in those who met physical activity guidelines and whose HDL-C concentration was low (hazard ratio: 1.07; 95% confidence interval: 0.75, 1.53). Compared with the reference group, all-cause mortality risk was elevated in those who did not meet physical activity guidelines and whose HDL-C was normal (1.37; 1.16, 1.61), and in those who did not meet physical activity guidelines and whose HDL-C was low (1.65; 1.37, 1.98). Cardiovascular disease mortality hazard ratios were similar, although confidence intervals were wider. There was no statistically significant evidence of biological interaction between physical inactivity and low HDL-C. This novel study supports the notion that leisure-time physical activity be recommended in those with low HDL-C concentration who may be resistant to the HDL-raising effect of exercise training. 相似文献
109.
Gill CJ Macleod WB Mwanakasale V Chalwe V Mwananyanda L Champo D Mukwamataba D Chilengi R Thea DM Hamer DH 《The Journal of infectious diseases》2007,196(11):1577-1584
BACKGROUND: The World Health Organization advocates 2-3 doses of sulfadoxine-pyrimethamine (SP) for intermittent preventive treatment of malaria (SP IPTp). The optimal number of doses and the consequences of single-dose therapy remain unclear.METHODS: Data were from a randomized, controlled study of human immunodeficiency virus-positive Zambian women comparing monthly versus 2-dose SP IPTp. We compared maternal and neonatal birth outcomes as a function of how many doses the mothers received (1 to > or =4 doses).RESULTS: Of 387 deliveries, 34 received 1 dose of SP. Single-dose SP was significantly associated with higher proportions of maternal anemia, peripheral and cord blood parasitemia, infant prematurity, and low birth weight. SP conferred dose-dependent benefits, particularly in the transition from 1 to 2 doses of SP. Women randomized to the standard 2-dose regimen were much more likely to receive only 1 dose than were women randomized to monthly IPT (relative risk, 16.4 [95% confidence interval, 4.0-68.3]).CONCLUSIONS: Single-dose SP was a common result of trying to implement the standard 2-dose regimen and was inferior to all other dosing regimens. At a programmatic level, this implies that monthly SP IPTp may ultimately be more effective than the standard regimen by reducing the risk of inadvertently underdosing mothers. 相似文献
110.
Hamer DH Mwanakasale V Macleod WB Chalwe V Mukwamataba D Champo D Mwananyanda L Chilengi R Mubikayi L Mulele CK Mulenga M Thea DM Gill CJ 《The Journal of infectious diseases》2007,196(11):1585-1594
BACKGROUND: Intermittent preventive treatment of malaria during pregnancy (IPTp) reduces placental infection, maternal anemia, and low birth weight (LBW). However, the optimal dosing regimen in settings in which human immunodeficiency virus (HIV) is highly prevalent among pregnant women remains controversial. METHODS: We conducted a randomized, double-blind, placebo-controlled study of IPTp comparing the standard 2-dose sulfadoxine-pyrimethamine (SP) regimen with monthly IPTp among a cohort of HIV-positive pregnant Zambian women. Primary outcomes included placental malaria (by smear and histology) and maternal peripheral parasitemia at delivery. RESULTS: There were no differences between monthly IPTp (n=224) and standard IPTp (n=232) in placental malaria by histopathology (26% vs. 29%; relative risk [RR], 0.90 [95% confidence interval {CI}, 0.64-1.26]) or placental parasitemia (2% vs. 4%; RR, 0.55 [95% CI, 0.17-1.79]). There also were no differences in maternal anemia, stillbirths, preterm delivery, LBW, or all-cause mortality of infants at 6 weeks.CONCLUSIONS: In an area of mesoendemicity in Zambia, monthly SP IPTp was not more efficacious than the standard 2-dose regimen for the prevention of placental malaria or adverse birth outcomes. IPTp policy recommendations need to take into account local malaria transmission patterns and the prevalence of HIV. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00270530. 相似文献