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排序方式: 共有179条查询结果,搜索用时 13 毫秒
171.
Fornage M Debette S Bis JC Schmidt H Ikram MA Dufouil C Sigurdsson S Lumley T DeStefano AL Fazekas F Vrooman HA Shibata DK Maillard P Zijdenbos A Smith AV Gudnason H de Boer R Cushman M Mazoyer B Heiss G Vernooij MW Enzinger C Glazer NL Beiser A Knopman DS Cavalieri M Niessen WJ Harris TB Petrovic K Lopez OL Au R Lambert JC Hofman A Gottesman RF Garcia M Heckbert SR Atwood LD Catellier DJ Uitterlinden AG Yang Q Smith NL Aspelund T Romero JR Rice K Taylor KD Nalls MA Rotter JI Sharrett R 《Annals of neurology》2011,69(6):928-939
172.
Fröbert O Lagerqvist B Gudnason T Thuesen L Svensson R Olivecrona GK James SK 《American heart journal》2010,160(6):1042-1048
173.
Svansdottir E Karlsson HD Gudnason T Olason DT Thorgilsson H Sigtryggsdottir U Sijbrands EJ Pedersen SS Denollet J 《Journal of behavioral medicine》2012,35(2):155-166
Type D personality has been associated with poor prognosis in cardiac patients. This study investigated the validity of the
Type D construct in Iceland and its association with disease severity and health-related risk markers in cardiac patients.
A sample of 1,452 cardiac patients completed the Type D scale (DS14), and a subgroup of 161 patients completed measurements
for the five-factor model of personality, emotional control, anxiety, depression, stress and lifestyle factors. The Icelandic
DS14 had good psychometric properties and its construct validity was confirmed. Prevalence of Type D was 26–29%, and assessment
of Type D personality was not confounded by severity of underlying coronary artery disease. Regarding risk markers, Type D
patients reported more psychopharmacological medication use and smoking, but frequency of previous mental problems was similar
across groups. Type D is a valid personality construct in Iceland, and is associated with health-related risk markers, but
not cardiac disease severity. 相似文献
174.
Johannesdottir F Poole KE Reeve J Siggeirsdottir K Aspelund T Mogensen B Jonsson BY Sigurdsson S Harris TB Gudnason VG Sigurdsson G 《BONE》2011,48(6):1268-1276
In this prospective nested case-control study we analyzed the circumferential differences in estimated cortical thickness (Est CTh) of the mid femoral neck as a risk factor for osteoporotic hip fractures in elderly women and men. Segmental QCT analysis of the mid femoral neck was applied to assess cortical thickness in anatomical quadrants. The superior region of the femoral neck was a stronger predictor for hip fracture than the inferior region, particularly in men. There were significant gender differences in Est CTh measurements in the control group but not in the case group. In multivariable analysis for risk of femoral neck (FN) fracture, Est CTh in the supero-anterior (SA) quadrant was significant in both women and men, and remained a significant predictor after adjustment for FN areal BMD (aBMD, dimensions g/cm2, DXA-like), (p=0.05 and p<0.0001, respectively). In conclusion, Est CTh in the SA quadrant best discriminated cases (n=143) from controls (n=298), especially in men. Cortical thinning superiorly in the hip might be of importance in determining resistance to fracture. 相似文献
175.
Amin N Byrne E Johnson J Chenevix-Trench G Walter S Nolte IM;kConFab Investigators Vink JM Rawal R Mangino M Teumer A Keers JC Verwoert G Baumeister S Biffar R Petersmann A Dahmen N Doering A Isaacs A Broer L Wray NR Montgomery GW Levy D Psaty BM Gudnason V Chakravarti A Sulem P Gudbjartsson DF Kiemeney LA Thorsteinsdottir U Stefansson K van Rooij FJ Aulchenko YS Hottenga JJ Rivadeneira FR Hofman A Uitterlinden AG Hammond CJ Shin SY Ikram A Witteman JC Janssens AC Snieder H Tiemeier H 《Molecular psychiatry》2012,17(11):1116-1129
Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18?176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis treating different cell lines with caffeine. Genome-wide significant association was observed for two single-nucleotide polymorphisms (SNPs) in the 15q24 region. The two SNPs rs2470893 and rs2472297 (P-values=1.6 × 10(-11) and 2.7 × 10(-11)), which were also in strong linkage disequilibrium (r(2)=0.7) with each other, lie in the 23-kb long commonly shared 5' flanking region between CYP1A1 and CYP1A2 genes. CYP1A1 was found to be downregulated in lymphoblastoid cell lines treated with caffeine. CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of coffee, whereas CYP1A2 is involved in the primary metabolism of caffeine. Significant evidence of association was also detected at rs382140 (P-value=3.9 × 10(-09)) near NRCAM-a gene implicated in vulnerability to addiction, and at another independent hit rs6495122 (P-value=7.1 × 10(-09))-an SNP associated with blood pressure-in the 15q24 region near the gene ULK3, in the meta-analysis of discovery and replication cohorts. Our results from GWASs and expression analysis also strongly implicate CAB39L in coffee drinking. Pathway analysis of differentially expressed genes revealed significantly enriched ubiquitin proteasome (P-value=2.2 × 10(-05)) and Parkinson's disease pathways (P-value=3.6 × 10(-05)). 相似文献
176.
Johnson AD Newton-Cheh C Chasman DI Ehret GB Johnson T Rose L Rice K Verwoert GC Launer LJ Gudnason V Larson MG Chakravarti A Psaty BM Caulfield M van Duijn CM Ridker PM Munroe PB Levy D;Cohorts for Heart Aging Research in Genomic Epidemiology Consortium;Global BPgen Consortium;Women's Genome Health Study 《Hypertension》2011,57(5):903-910
We previously conducted genome-wide association meta-analysis of systolic blood pressure, diastolic blood pressure, and hypertension in 29,136 people from 6 cohort studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Here we examine associations of these traits with 30 gene regions encoding known antihypertensive drug targets. We find nominal evidence of association of ADRB1, ADRB2, AGT, CACNA1A, CACNA1C, and SLC12A3 polymorphisms with 1 or more BP traits in the Cohorts for Heart and Aging Research in Genomic Epidemiology genome-wide association meta-analysis. We attempted replication of the top meta-analysis single nucleotide polymorphisms for these genes in the Global BPgen Consortium (n=34,433) and the Women's Genome Health Study (n=23,019) and found significant results for rs1801253 in ADRB1 (Arg389Gly), with the Gly allele associated with a lower mean systolic blood pressure (β: 0.57 mm Hg; SE: 0.09 mm Hg; meta-analysis: P=4.7×10(-10)), diastolic blood pressure (β: 0.36 mm Hg; SE: 0.06 mm Hg; meta-analysis: P=9.5×10(-10)), and prevalence of hypertension (β: 0.06 mm Hg; SE: 0.02 mm Hg; meta-analysis: P=3.3×10(-4)). Variation in AGT (rs2004776) was associated with systolic blood pressure (β: 0.42 mm Hg; SE: 0.09 mm Hg; meta-analysis: P=3.8×10(-6)), as well as diastolic blood pressure (P=5.0×10(-8)) and hypertension (P=3.7×10(-7)). A polymorphism in ACE (rs4305) showed modest replication of association with increased hypertension (β: 0.06 mm Hg; SE: 0.01 mm Hg; meta-analysis: P=3.0×10(-5)). Two loci, ADRB1 and AGT, contain single nucleotide polymorphisms that reached a genome-wide significance threshold in meta-analysis for the first time. Our findings suggest that these genes warrant further studies of their genetic effects on blood pressure, including pharmacogenetic interactions. 相似文献
177.
Harris P Alcantara DA Amenta N Lopez OL Eiríksdóttir G Sigurdsson S Gudnason V Madsen S Thompson PM Launer LJ Carmichael OT 《NeuroImage》2008,43(3):489-496
Hypertension is highly prevalent in elderly individuals and may be associated with cognitive decline, but the mechanisms by which hypertension may impact brain structure, and thereby modulate the time course of late-life cognitive performance, are not well understood. Therefore we used Localized Components Analysis, a novel computational method, to measure spatially-localized patterns of corpus callosum (CC) atrophy in 28 right-handed female subjects aged 75-79 years in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik), a large-scale epidemiological study of aging. Localized callosal atrophy in the posterior midbody and splenium was significantly associated with systolic blood pressure in linear statistical models that controlled for age, while associations between blood pressure and anterior CC atrophy measures were not statistically significant. Additionally, overall measures of global CC atrophy were not significantly associated with blood pressure. The posterior CC may be differentially vulnerable to hypertension-associated atrophy, possibly due to its relatively tenuous vascularization. 相似文献
178.
Emerging Risk Factors Collaboration Seshasai SR Kaptoge S Thompson A Di Angelantonio E Gao P Sarwar N Whincup PH Mukamal KJ Gillum RF Holme I Njølstad I Fletcher A Nilsson P Lewington S Collins R Gudnason V Thompson SG Sattar N Selvin E Hu FB Danesh J 《The New England journal of medicine》2011,364(9):829-841
179.
Pukkala E Andersen A Berglund G Gislefoss R Gudnason V Hallmans G Jellum E Jousilahti P Knekt P Koskela P Kyyrönen PP Lenner P Luostarinen T Löve A Ogmundsdóttir H Stattin P Tenkanen L Tryggvadóttir L Virtamo J Wadell G Widell A Lehtinen M Dillner J 《Acta oncologica (Stockholm, Sweden)》2007,46(3):286-307
The Nordic countries have a long tradition of large-scale biobanking and comprehensive, population-based health data registries linkable on unique personal identifiers, enabling follow-up studies spanning many decades. Joint Nordic biobank-based studies provide unique opportunities for longitudinal molecular epidemiological research. The purpose of the present paper is to describe the possibilities for such joint studies, by describing some of the major Nordic biobank cohorts with a standardised calculation of the cancer incidence in these cohorts. Altogether two million donors have since 1966 donated more than four million biological samples, stored at -20 degrees C to -135 degrees C, to 17 biobank cohorts in Finland, Iceland, Norway and Sweden. As a result of joint database handling principles, the accuracy of personal identifiers and completeness of follow-up for vital status in all participating biobanks was improved. Thereafter, the cancer incidence was determined using follow-up through the national cancer registries. Biobanks based on random samples of population typically showed slightly lower cancer incidence rates than the general population, presumably due to better participation rates among health-conscious subjects. On the other hand, biobanks including samples for viral screening or clinical testing showed 1.5 to 2.1 fold increased incidence of cancer. This excess was very high immediately after sampling, but for some cancer sites remained elevated for years after clinical sampling. So far, more than 100 000 malignant neoplasms have occurred after sample donation, and the annual increase of the cancer cases in these cohorts is about 10 000. The estimates on the population-representativity of the biobanks will assist in interpretation of generalizability of results of future studies based on these samples, and the systematic tabulations of numbers of cancer cases will serve in study power estimations. The present paper summarizes optimal study designs of biobank-based studies of cancer. 相似文献