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Carers' Assessment,Skills and Information Sharing (CASIS) Trial: A Qualitative Study of the Experiential Perspective of Caregivers and Patients
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Jeff D. Overington Yao C. Huang Michael J. Abramson Juliet L. Brown John R. Goddard Rayleen V. Bowman Kwun M. Fong Ian A. Yang 《Journal of thoracic disease》2014,6(11):1586-1596
Chronic obstructive pulmonary disease (COPD) is a complex chronic lung disease characterised by progressive fixed airflow limitation and acute exacerbations that frequently require hospitalisation. Evidence-based clinical guidelines for the diagnosis and management of COPD are now widely available. However, the uptake of these COPD guidelines in clinical practice is highly variable, as is the case for many other chronic disease guidelines. Studies have identified many barriers to implementation of COPD and other guidelines, including factors such as lack of familiarity with guidelines amongst clinicians and inadequate implementation programs. Several methods for enhancing adherence to clinical practice guidelines have been evaluated, including distribution methods, professional education sessions, electronic health records (EHR), point of care reminders and computer decision support systems (CDSS). Results of these studies are mixed to date, and the most effective ways to implement clinical practice guidelines remain unclear. Given the significant resources dedicated to evidence-based medicine, effective dissemination and implementation of best practice at the patient level is an important final step in the process of guideline development. Future efforts should focus on identifying optimal methods for translating the evidence into everyday clinical practice to ensure that patients receive the best care. 相似文献
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I. Conradie van Wyk A. Goddard B. M. de C. Bronsvoort J. A. W. Coetzer C. Booth O. Hanotte A. Jennings H. Kiara P. Mashego C. Muller G. Pretorius E. J. Poole S. M. Thumbi P. G. Toye M. E. J. Woolhouse B. L. Penzhorn 《Comparative clinical pathology》2013,22(5):1029-1036
This paper is the first attempt to accurately describe the hematological parameters for any African breed of cattle, by capturing the changes in these parameters over the first 12 months of an animal’s life using a population-based sample of calves reared under field conditions and natural disease challenge. Using a longitudinal study design, a stratified clustered random sample of newborn calves was recruited into the IDEAL study and monitored at 5-weekly intervals until 51 weeks of age. The blood cell analysis performed at each visit included: packed cell volume; red cell count; red cell distribution width; mean corpuscular volume; mean corpuscular hemoglobin concentration; hemoglobin concentration; white cell count; absolute lymphocyte, eosinophil, monocyte, and neutrophil counts; platelet count; mean platelet volume; and total serum protein. The most significant age-related change in the red cell parameters was a rise in red cell count and hemoglobin concentration during the neonatal period. This is in contrast to what is reported for other ruminants, including European cattle breeds where the neonatal period is marked by a fall in the red cell parameters. There is a need to establish breed-specific reference ranges for blood parameters for indigenous cattle breeds. The possible role of the postnatal rise in the red cell parameters in the adaptability to environmental constraints and innate disease resistance warrants further research into the dynamics of blood cell parameters of these breeds. 相似文献
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An examination of the clinical outcomes of adolescents and young adults with broad autism spectrum traits and autism spectrum disorder and anorexia nervosa: A multi centre study
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Bruno Palazzo Nazar MD MSc PhD Vanessa Peynenburg BA Charlotte Rhind BSc MSc PhD Rebecca Hibbs PhD Ulrike Schmidt MD PhD Simon Gowers MD PhD Pamela Macdonald PhD Elizabeth Goddard PhD Gillian Todd RMN MSc Nadia Micali MD PhD Janet Treasure OBE PhD FRCP FAED 《The International journal of eating disorders》2018,51(2):174-179
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Ousseny Zerbo Ned Lewis Bruce Fireman Kristin Goddard Jacek Skarbinski James J. Sejvar Eduardo Azziz-Baumgartner Nicola P. Klein 《Influenza and other respiratory viruses》2022,16(1):159-165
Among approximately 4.6 million members of Kaiser Permanente Northern California, we examined associations of severe COVID-19 with demographic factors and comorbidities. As of July 23, 2021, 16 182 had been hospitalized, 2416 admitted to an ICU, and 1525 died due to COVID-19. Age was strongly associated with hospitalization, ICU admission, and death. Black persons and Hispanic ethnicity had higher risk of death compared with Whites. Among the comorbidities examined, Alzheimer's disease was associated with the highest risk for hospitalization (aHR 3.19, CI: 2.88–3.52) and death (aHR 4.04, CI: 3.32–4.91). Parkinson's disease had the second highest risk of death (aHR = 2.07, CI: 1.50–2.87). 相似文献