全文获取类型
收费全文 | 5414篇 |
免费 | 308篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 82篇 |
儿科学 | 155篇 |
妇产科学 | 87篇 |
基础医学 | 588篇 |
口腔科学 | 74篇 |
临床医学 | 383篇 |
内科学 | 1383篇 |
皮肤病学 | 51篇 |
神经病学 | 384篇 |
特种医学 | 422篇 |
外科学 | 1017篇 |
综合类 | 62篇 |
预防医学 | 238篇 |
眼科学 | 94篇 |
药学 | 319篇 |
中国医学 | 12篇 |
肿瘤学 | 412篇 |
出版年
2022年 | 82篇 |
2021年 | 140篇 |
2020年 | 75篇 |
2019年 | 101篇 |
2018年 | 147篇 |
2017年 | 116篇 |
2016年 | 124篇 |
2015年 | 147篇 |
2014年 | 190篇 |
2013年 | 223篇 |
2012年 | 317篇 |
2011年 | 335篇 |
2010年 | 212篇 |
2009年 | 183篇 |
2008年 | 242篇 |
2007年 | 249篇 |
2006年 | 237篇 |
2005年 | 235篇 |
2004年 | 217篇 |
2003年 | 187篇 |
2002年 | 168篇 |
2001年 | 124篇 |
2000年 | 116篇 |
1999年 | 95篇 |
1998年 | 78篇 |
1997年 | 86篇 |
1996年 | 80篇 |
1995年 | 76篇 |
1994年 | 66篇 |
1993年 | 47篇 |
1992年 | 69篇 |
1991年 | 57篇 |
1990年 | 63篇 |
1989年 | 61篇 |
1988年 | 83篇 |
1987年 | 63篇 |
1986年 | 63篇 |
1985年 | 74篇 |
1984年 | 43篇 |
1983年 | 52篇 |
1982年 | 39篇 |
1981年 | 30篇 |
1980年 | 26篇 |
1979年 | 51篇 |
1978年 | 37篇 |
1977年 | 31篇 |
1976年 | 37篇 |
1975年 | 27篇 |
1974年 | 29篇 |
1973年 | 33篇 |
排序方式: 共有5763条查询结果,搜索用时 48 毫秒
91.
Inhibition of cyclooxygenase-2 indirectly potentiates antitumor effects of photodynamic therapy in mice. 总被引:2,自引:0,他引:2
Marcin Makowski Tomasz Grzela Justyna Niderla Maciej ?Azarczyk Pawe? Mróz Maciej Kopeé Magdalena Legat Katarzyna Strusińska Katarzyna Koziak Dominika Nowis Piotr Mrówka Maria Wasik Marek Jakóbisiak Jakub Go?ab 《Clinical cancer research》2003,9(14):5417-5422
PURPOSE: The aim of the present study was to potentiate the antitumor effectiveness of photodynamic therapy (PDT). A cDNA microarray analysis was used to evaluate the gene expression pattern after Photofrin-mediated PDT to find more effective combination treatment with PDT and inhibitor(s) of the identified gene product(s) overexpressed in tumor cells. EXPERIMENTAL DESIGN: Atlas Mouse Stress Array was used to compare the expression profile of control and PDT-treated C-26 cells. The microarray results have been confirmed using Western blotting. Cytostatic/cytotoxic in vitro assay as well as in vivo tumor models were used to investigate the antitumor effectiveness of PDT in combination with cyclooxygenase (COX) 2 inhibitors. RESULTS: PDT induced the expression of 5 of 140 stress-related genes. One of these genes encodes for COX-2, an enzyme important in the tumor progression. Inhibition of COX-2 in vitro with NS-398, rofecoxib, or nimesulide, or before PDT with nimesulide did not influence the therapeutic efficacy of the treatment. Administration of a selective COX-2 inhibitor after PDT produced potentiated antitumor effects leading to complete responses in the majority of treated animals. CONCLUSIONS: COX-2 inhibitors do not sensitize tumor cells to PDT-mediated killing. However, these drugs can be used to potentiate the antitumor effectiveness of this treatment regimen when administered after tumor illumination. 相似文献
92.
Wang WS; Hsieh RK; Chiou TJ; Liu JH; Fan FS; Yen CC; Tung SL; Chen PM 《Japanese journal of clinical oncology》1998,28(9):551-554
A 54-year-old man was treated with weekly 24-h infusion of high-dose
5-fluorouracil (2600 mg/m2) and leucovorin (100 mg/m2) for metastatic colon
cancer. At first, he tolerated the treatment well and no significant
toxicity was identified. After a total of eight courses of treatment, a
stable disease was observed, but mild shortness of breath was found on
occasion. The patient had no previous history of cardiac disease and the
heart performance assessed by left ventricular ejection fraction before
treatment was normal. Unfortunately, acute pulmonary edema with lethal
cardiogenic shock occurred during the ninth course of treatment, in spite
of intensive medical treatment. The chest X-ray showed extreme
cardiomegaly. Repeated assessment of his heart function by echocardiogram
and ventricular ejection fraction revealed a very poor cardiac performance.
Toxic cardiogenic shock during weekly 24-h infusion of high-dose
5-fluorouracil and leucovorin is extremely rare. To the best of our
knowledge, no case has been reported in the English literature. We report a
case and the relevant literature about the incidence, clinical picture and
possible pathophysiology on 5-fluorouracil-related cardioxicity is
reviewed.
相似文献
93.
Tsujimoto G 《Annals of nuclear medicine》2000,14(3):165-172
Global and regional myocardial uptake was determined with technetium-99m tetrofosmin and a 4 hour exercise (370 MBq i.v.) and rest (740 MBq i.v.) protocol, in 24 patients with non-insulin dependent diabetes mellitus and in 22 control subjects. The purpose of this study was to evaluate impaired coronary microvascular function in diabetics by measurement of % uptake increase in myocardial counts. The parameter of % uptake increase (deltaMTU) was calculated as the ratio of exercise counts to rest myocardial counts with correction of myocardial uptake for dose administered and physical decay between the exercise study and the rest study. Global deltaMTU was significantly lower in the diabetics than in control subjects (14.4 +/- 5.4% vs. 21.7 +/- 8.5%, p < 0.01). Regional deltaMTU in each of 4 left ventricular regions (anterior, septal, inferior, posterolateral) was significantly lower in the diabetic group than in the control group (p < 0.01) respectively, but there were no significant differences between deltaMTU in the 4 left ventricular regions in the same group. deltaMTU was useful as a non-invasive means of evaluating impaired coronary microvascular function in diabetics. 相似文献
94.
An unusual case of a calculus in the ileal neobladder is presented. The size of the stone is exceptional in the urologic literature (940 g). Neocystolithotomy was performed, with full patient recovery. 相似文献
95.
Takeshi Yoshida Go Suzuki Masashi Nibuya Shin-ya Sano Soichiro Nomura 《Nihon shinkei seishin yakurigaku zasshi》2004,24(1):29-31
Although still controversial, iron deficiency has been indicated as one of the risk factors for developing neuroleptic-induced extrapyramidal symptoms (EPSs), including akathisia, dystonia, and neuroleptic malignant syndrome. Here we report our experience of iron supplementation and alternating neuroleptics for treating Parkinsonism in a schizophrenic female patient having severe iron deficient anemia. 相似文献
96.
97.
Y. S. Cha J. Go T. H. Kim O. H. Kim K. C. Cha 《Clinical toxicology (Philadelphia, Pa.)》2014,52(8):873-879
Background. In organophosphate (OP) poisoning cardiac complications may occur. However, the current body of knowledge largely consists of limited studies, and case reports are mainly on electrocardiogram (ECG) abnormalities. As definite myocardial injury is difficult to assess through ECG, we investigated the prevalence of myocardial injury through cardiac biochemical markers such as troponin I (TnI) in severe OP poisoning. Methods. We conducted a retrospective review of 99 consecutive OP insecticide poisoning cases that were diagnosed and treated at the emergency department of the Wonju Severance Christian Hospital between March 2008 and December 2013. Results. Based on Namba classification for OP poisoning, there were no patients with mild toxicity, 9 patients (9.1%) with moderate toxicity and 90 patients (90.9%) with severe toxicity. On ECG, normal sinus rhythm was most common, and ST depression and elevation were seen in 11 patients (11.1%). Elevation of TnI within 48 h was seen in 34 patients (34.3%). The median peak level and peak time of TnI were 0.305 (IQR, 0.078–2.335) ng/mL and 15 (IQR 6.9–34.4) hours, respectively. There were differences between patients with normal TnI and elevated TnI in terms of age (yrs), number of patients who were exposed to OP via the oral route, and initial Glasgow Coma Scale (GCS; 58 ± 17 vs. 66 ± 16, p = 0.015, 56 [87.5%] vs. 33 [97.1%], p = 0.048 and 12.0 [IQR, 8.0–15.0] vs. 9.0 [IQR, 5.8–12.0], p = 0.019). Conclusions. OP can cause direct myocardial injury during the acute early phase in severe OP poisoning. Monitoring of TnI may be needed in severe OP poisoning. 相似文献
98.
99.
100.