Cell-based assays for the detection of MOG antibodies: a comparative study

Journal of Neurology - The detection of antibodies to myelin oligodendrocyte glycoprotein (MOG) is fundamental for the identification of MOG antibody-associated disorders (MOGAD), and the...     

A case of Jarisch–Herxheimer reaction in candidiasis treated with systemic fluconazole

Jarisch–Herxheimer reaction (JHR) is an acute and self‐limited condition, which commonly occurs after treatment for spirochetal infections. Probably, it corresponds to a transient immunological reaction to endotoxin‐like products released from the microorganism during the therapy. For this reason, JHR may be associated with many other infectious diseases besides syphilis. Here, we report a case of a patient affected by extended cutaneous candidiasis diagnosed by culture examination; a JHR occurred after an accidental overdose of oral fluconazole.     

Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls

Journal of NeuroVirology - The aim of this study was to review the quality of the diagnostic work-up for acute encephalitis carried out at our center in a cohort of patients with hematological...     

Symmetric patterns with different luminance polarity (anti‐symmetry) generate an automatic response in extrastriate cortex

People can quickly detect bilateral reflection in an image. This is true when elements of the same luminance are matched on either side of the axis (symmetry) and when they have opposite luminance polarity (anti‐symmetry). Using electroencephalography, we measured the well‐established sustained posterior negativity (SPN) response to symmetry and anti‐symmetry. In one task, participants judged the presence or absence of regularity (Regularity Discrimination Task). In another, they judged the presence or absence of rare colored oddball trials (Colored Oddball Task). Previous work has concluded that anti‐symmetry is only detected indirectly, through serial visual search of element locations. This selective attention account predicts that the anti‐symmetry SPN should be abolished in the Colored Oddball Task because there is no need to search for anti‐symmetry. However, this prediction was not confirmed: The symmetry and anti‐symmetry SPN waves were not modulated by task. We conclude that at least some forms of anti‐symmetry can be extracted from the image automatically, in much the same way as symmetry. This is an important consideration for models of symmetry perception, which must be flexible enough to accommodate opposite luminance polarity, while also accounting for the fact anti‐symmetry is often perceptually weaker than symmetry.     

Jesus is in Favor: Catholicism and Assisted Reproduction in Italy

While religion is part of the modernities of assisted reproductive technologies (ART), this has mainly been investigated in non-Western or non-Christian contexts. In this article, I argue that in contemporary Italy, Catholicism affects not only law- and policymaking processes but also (prospective) parents’ experiences of ART and donor conception in contradictory and unexpected ways. Officially, the Roman Church strongly opposes ART, but Catholic principles, affiliations, and rituals are mobilized in ways that contribute to legitimizing and making sense of ART as a means to create kinship and reproduce Italian national identity.     

Experimental Investigations on Dry Sliding Wear Behavior of Kevlar and Natural Fiber-Reinforced Hybrid Composites through an RSM–GRA Hybrid Approach

The present work aimed to investigate the dry sliding wear behaviors of hybrid polymer matrix composites made up of Kevlar, bamboo, palm, and Aloe vera as reinforcement materials of varying stacking sequences, along with epoxy as the matrix material. Three combinations of composite laminates with different stacking sequences such as AB, BC, and CA were fabricated by a vacuum-assisted compression molding process. The influence of composite laminates fabricated through various stacking sequences and dry sliding wear test variables such as load, sliding distance, and sliding velocity on the specific wear rate and co-efficient of friction were investigated. Experiments were designed and statistical validation was performed through response surface methodology-based D-optimal design and analysis of variance. The optimization was performed using grey relational analysis (GRA) to identify the optimal parameters to enhance the wear resistance of hybrid polymer composites under dry sliding conditions. The optimal parameters, such as composite combinations of CA, a load of 5 N, a sliding velocity of 3 m/s, and a sliding distance of 1500 m, were obtained. Furthermore, the morphologies of worn-out surfaces were investigated using SEM analysis.     

Vibration Fatigue of FDM 3D Printed Structures: The Use of Frequency Domain Approach

Additive manufactured structures are replacing the corresponding ones realized with classical manufacturing technique. As for metallic structures, 3D printed components are generally subjected to dynamic loading conditions which can lead to fatigue failure. In this context, it is useful, and sometimes mandatory, to determine the fatigue life of such components through numerical simulation. The methods currently available in literature for the estimation of fatigue life were originally developed for metallic structures and, therefore, it is now necessary to verify their applicability also for components fabricated with different materials. To this end, in the current activity three of the most used spectral methods for the estimation of fatigue life were used to determine the fatigue life of a 3D printed Y-shaped specimen realized in polylactic acid subjected to random loads with the aim of determining their adaptability also for this kind of materials. To certify the accuracy of the numerical prediction, a set of experimental tests were conducted in order to obtain the real fatigue life of the component and to compare the experimental results with those numerically obtained. The obtained outcomes showed there is an excellent match between the numerical and the experimental data, thus certifying the possibility of using the investigated spectral methods to predict the fatigue life of additive manufactured components.